Screening of aflatoxin M1, a metabolite of aflatoxin B1 in human urine samples in Malaysia: A preliminary study

Sabran, Mohd; Jamaluddin, Rosita; Mutalib, Mohd Sokhini Abdul

doi:10.1016/j.foodcont.2012.04.048

Cited by 28 publications

(19 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although AFM1 is known as a possible human carcinogen, Codex Alimentarius set the maximum intake limit of AFM 1 at 50 ng/kg (Codex Alimentarius Commission ). AFM1 has been reported in milk, neonatal cord blood, and urine (Lamplugh and others ; Maxwell and others ; Galvano and others ; Martins and Martins ; Mykkänen and others ; Gürbay and others ; Polychronaki and others ; Virdis and others ; Nuryono and others ; Hussain and others ; Mohd Redzwan and others ; Sabran and others ; Suriyasathaporn and Nakprasert ). AFM1 was also reported in pasteurized milk, ultrahigh‐treated milk, milk powder, and some milk‐based products (Montagna and others ; Shundo and others ; Ghazani ; Fallah ).…”

Section: Occurrence Of Afsmentioning

confidence: 94%

A Review on Mycotoxins in Food and Feed: Malaysia Case Study

Afsah‐Hejri

Selamat

Hajeb

et al. 2013

Comp Rev Food Sci Food Safe

189

129

View full text Add to dashboard Cite

Fungi are distributed worldwide and can be found in various foods and feedstuffs from almost every part of the world. Mycotoxins are secondary metabolites produced by some fungal species and may impose food safety risks to human health. Among all mycotoxins, aflatoxins (AFs), ochratoxin A (OTA), trichothecenes, deoxynivalenol (DON and T-2 toxin), zearalenone (ZEN), and fumonisins (FMN) have received much attention due to high frequency and severe health effects in humans and animals. Malaysia has heavy rainfall throughout the year, high temperatures (28 to 31• C), and high relative humidity (70% to 80% during wet seasons). Stored crops under such conditions can easily be contaminated by mycotoxin-producing fungi. The most important mycotoxins in Malaysian foods are AFs, OTA, DON, ZEN, and FMN that can be found in peanuts, cereal grains, cocoa beans, and spices. AFs have been reported to occur in several cereal grains, feeds, nuts, and nut products consumed in Malaysia. Spices, oilseeds, milk, eggs, and herbal medicines have been reported to be contaminated with AFs (lower than the Malaysian acceptable level of 35 ng/g for total AFs). OTA, a possible human carcinogen, was reported in cereal grains, nuts, and spices in Malaysian market. ZEN was detected in Malaysian rice, oat, barley, maize meal, and wheat at different levels. DON contamination, although at low levels, was reported in rice, maize, barley, oat, wheat, and wheat-based products in Malaysia. FMN was reported in feed and some cereal grains consumed in Malaysia. Since some food commodities are more susceptible than others to fungal growth and mycotoxin contamination, more stringent prevention and control methods are required.

show abstract

Section: Occurrence Of Afsmentioning

confidence: 94%

A Review on Mycotoxins in Food and Feed: Malaysia Case Study

Afsah‐Hejri

Selamat

Hajeb

et al. 2013

Comp Rev Food Sci Food Safe

189

129

View full text Add to dashboard Cite

show abstract

“…Aflatoxin is a major mycotoxin and produced by Aspergillus species of fungi namely Aspergillus flavus, Aspergillus paraciticus, and Aspergillus nomius (Reddy et al, 2011;Sabran et al, 2012). Historically, the discovery of "Turkey X" disease caused by aflatoxin in 1950s and early 1960s had opened new prospectus on the scientific research of aflatoxin and preventive strategies in foods, animals, and humans (Kensler et al, 2011).…”

Section: Aflatoxin and Historical Backgroundmentioning

confidence: 99%

Probiotics as Potential Adsorbent of Aflatoxin

Redzwan

Jamaluddin

Ahmad

et al. 2016

Probiotics, Prebiotics, and Synbiotics

Self Cite

View full text Add to dashboard Cite

“…Human and animal health subjects to various influences of food contaminants, one of which of utmost concern in food safety is mycotoxins, secondary metabolites of some fungi of Aspergillus , Penicillium , and Fusarium species (Sweeney & Dobson, ). Mycotoxin is ubiquitously found in human foodstuffs, namely wine, coffee beans, nuts, spices, herbs, animal feed, and the like (Binder, ; Sabran, Jamaluddin, & Mutalib, ; Sabran, Jamaluddin, Mutalib, Sokhini, & Ahmad, ). The chief route of mycotoxin entry into the food chain occurs through consumption of contaminated foodstuffs of grain as well as some commodities, particularly in the case of milk, meat, and eggs, which are obtained from animals fed by mycotoxin‐intoxicated feedstuffs (Bryden, ).…”

Section: Introductionmentioning

confidence: 99%

“…Aspergillus species including Aspergillus flavus and Aspergillus paraciticus are the main producer of AF, polycyclic aromatic hydrocarbon (Mahfouz, ; Sabran et al, ). Among several AF metabolites, aflatoxin B1 (AFB1) is the most prevalent and potent form, arranged into Group 1 carcinogen to humans, which might cause hepatocellular carcinoma (HCC) (Cullen & Newberne, ; IARC—International Agency for Research on Cancer, ).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of curcumin against aflatoxicosis: A comprehensive review

Mohajeri

Behnam

Cicero

et al. 2017

Journal Cellular Physiology

View full text Add to dashboard Cite

Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non-enzymatic antioxidants are manifestations of aflatoxicosis. Curcuma longa L. (turmeric) is a medicinal plant widely utilized all over the world for culinary and phytomedical purposes. Considering the antioxidant characteristic of curcumin, the main active component of turmeric, this review is intended to critically summarize the available evidence supporting possible effectiveness of curcumin against aflatoxicosis. Curcumin can serve as a promising candidate for attenuation of the adverse consequences of aflatoxicosis, acting mainly through intrinsic antioxidant effects aroused from its structure, modulation of the immune system as reflected by interleukin-1β and transforming growth factor-β, and interfering with AF's biotransformation by cytochrome P450 isoenzymes CYP1A, CYP3A, CYP2A, CYP2B, and CYP2C.

show abstract

Screening of aflatoxin M1, a metabolite of aflatoxin B1 in human urine samples in Malaysia: A preliminary study

Cited by 28 publications

References 14 publications

A Review on Mycotoxins in Food and Feed: Malaysia Case Study

A Review on Mycotoxins in Food and Feed: Malaysia Case Study

Probiotics as Potential Adsorbent of Aflatoxin

Protective effects of curcumin against aflatoxicosis: A comprehensive review

Contact Info

Product

Resources

About