Screening of Anti-hyperglycemic Activity of Kigelia africana on Alloxan-Induced Diabetic Rats

Priya, Bhanu; Gahlot, Manoj; Joshi, Punam

doi:10.15373/2249555x/june2014/140

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Preliminary phytochemical screening of the four crude leaf extracts (hexane, chloroform, methanol, and distilled water) revealed the presence of saponins, oligosaccharides, alkaloids, phenolic compounds, tannins, and sterols. This result is consistent with those of Priya et al (2013), who identified alkaloids, steroids, saponins, tannins, and phenols in crude leaf extracts of K. africana. Monosaccharides, fixed fats, and oils tested negative possibly because of human error or because the leaf extracts were too diluted to react with the reagents.…”

Section: Discussionsupporting

confidence: 92%

Foliar Micromorphology and Histo-phytochemistry of Cucumber Trees (Kigelia africana (Lam.) Benth)

Naidoo,

Dewir

et al. 2024

Egypt. J. Bot.

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K IGELIA AFRICANA belongs to the family Bignoniaceae, and this species has been exploited for many years for its medicinal properties caused by the secondary metabolites found in its fruit. Thus, this study aimed to determine the foliar micromorphology and histophytochemistry of K. africana leaf extracts using microscopy, histochemistry, and phytochemical screening. Microscopy revealed glandular peltate trichomes on the adaxial and abaxial surfaces of young and mature leaflets. Histochemical analysis showed that the peltate trichomes secreted lipids and alkaloids, and histo-phytochemical analysis indicated that the leaf extracts contained various secondary metabolites, including alkaloids, saponins, tannins, and phenols. The presence of glandular trichomes is a characteristic feature of species belonging to the family Bignoniaceae, and the phytochemicals present in the leaf extracts were similar to those found in fruit extracts. This study revealed the presence of peltate trichomes on the surfaces of young and mature leaflets, and histo-phytochemistry showed that the leaves contained various classes of phytochemical compounds. However, further work must be conducted to investigate the fine ultrastructure of the leaves and peltate trichomes as well as the biological activity of various phytochemicals.

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Section: Discussionsupporting

confidence: 92%

Foliar Micromorphology and Histo-phytochemistry of Cucumber Trees (Kigelia africana (Lam.) Benth)

Naidoo,

Dewir

et al. 2024

Egypt. J. Bot.

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“…Similarly, methanolic extract from the leaves was found to significantly decrease (P<0.01) serum glucose level in alloxan-induced diabetic rats after the 21 days of oral treatment (Priya et al, 2014). The ethanolic extract, together with compounds catalpol, specioside and minecoside (10 μM) isolated from the n-butanol fraction exhibited significant stimulation of GLUT4 translocation to cell surface from intracellular compartments (Khan et al, 2012).…”

Section: Kigelia Africanamentioning

confidence: 88%

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

Yagi¹,

Yagi²

2018

Afr. J. Pharm. Pharmacol.

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“…The results indicated that the extract markedly reduced the blood glucose level in the diabetic rats. 134) In a separate study, extracts of K. africana leaves, using acetone, ethanol, chloroform, and water, were tested for α-amylase inhibition, the ethanol extract (500 µg/mL) showed the highest α-amylase inhibition. 135) Diospyros kaki L. (Ebenaceae), a particular fruit-producing plant native to China, has traditionally been used for the treatment of various diseases in many regions of the world, including Thailand.…”

Section: )mentioning

confidence: 99%

Antidiabetic Naphthoquinones and Their Plant Resources in Thailand

Shah

Keach²,

Panichayupakaranant

2018

Chem. Pharm. Bull.

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Diabetes mellitus is the seventh leading cause of death globally. Ninety percent of the diabetic population suffers from type-2 diabetes, which still needs an effective, safe and economical oral hypoglycemic therapy. Plants are rich sources of various therapeutic molecules. More than 400 medicinal plants of interesting phytochemical diversity have been reported for their antidiabetic potential. Naphthoquinones are a group of phytochemicals, which have a wide range of pharmacological potential, including antidiabetic activity. Naphthoquinones exert their antidiabetic effects through various mechanisms such as the inhibition of α-glucosidase and protein tyrosine phosphatase 1B, increased glucose uptake in myocytes and adipocytes via glucose transporter type 4 (GLUT4) and GLUT2 translocations, enhanced peroxisome proliferator-activated receptor gamma (PPARγ) ligand activity, and by normalizing carbohydrate metabolizing enzymes in the liver. Moreover, naphthoquinone inhibits adipogenesis by both upstream and downstream regulation to control obesity, which is one of the important risk factors for diabetes. Naturally occurring naphthoquinones, as well as their plant sources, are therefore of interest for exploring their antidiabetic potential. The present review aims to overview the antidiabetic potential of naphthoquinones and their plant resources in Thailand.

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Screening of Anti-hyperglycemic Activity of Kigelia africana on Alloxan-Induced Diabetic Rats

Cited by 5 publications

References 11 publications

Foliar Micromorphology and Histo-phytochemistry of Cucumber Trees (Kigelia africana (Lam.) Benth)

Foliar Micromorphology and Histo-phytochemistry of Cucumber Trees (Kigelia africana (Lam.) Benth)

Traditional medicinal plants used for the treatment of diabetes in the Sudan: A review

Antidiabetic Naphthoquinones and Their Plant Resources in Thailand

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