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Aim:The objective of the present study was to screen the anti-hyperglycaemic and antihyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nicotinamide induced NIDDM rats. Methods: Acute oral toxicity of all extracts was carried out with a single dose of 2000 mg/kg in female non-pregnant albino Wistar rats. An oral glucose tolerance test was performed for all extracts in overnight fasted rats. The anti-hyperglycaemic and anti-hyperlipidemic activities were carried out on adult healthy albino Wistar rats of either sex. Diabetogenic drug Streptozotocin and Nicotinamide were administrated by intraperitoneal route. Standard drug glibenclamide was administered by the peroral route. Test drugs (extracts) were administered in doses of 200 mg/kg by the peroral route. Diabetic rats with serum glucose levels more than 250 mg/dl were selected for the study. Bodyweight, fasting serum glucose levels, and other biochemical parameters were monitored on the 1 st , 15 th , and 21 st day. Results: All four-leaf extract showed significant anti-hyperglycemic and lipid-lowering activity. Maximum activity was shown by methanolic extract (effect on FSGL=282.20±5.29 on day 1st to 139. 20±3.46 on 21 st day, p˂0.01), (effect on lipid parameters= (TG=105.69±0.71 on 15 th day to 110.19±0.70 on 21 st day, p˂0.01, CH=105.68±0.50 on 15 th day to 111.37±0.48 on 21 st day, p˂0.01 and S.HDL=37.29±0.22 on 15 th day to 38.05±0.44 on 21 st day, p˂0.01. Conclusion: From the present study a conclusion can be drawn that the methanolic extract of C. glauca leaves possesses potential anti-hyperglycaemic and anti-hyperlipidemic properties.

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