Screening of antimalarial drugs: An overview

Kalra, B. S.; Chawla, Sumit; Gupta, Pooja; Valecha, Neena

doi:10.4103/0253-7613.19846

Cited by 99 publications

(110 citation statements)

References 38 publications

Supporting

Mentioning

110

Contrasting

Order By: Relevance

“…Untreated control mice typically die approximately 1 week after infection 15 . For treated mice the survival time (in days) was recorded and the mean survival time was calculated in comparison with that of the negative control group 16 .…”

Section: In Vivo Anti-malarial Activitymentioning

confidence: 99%

Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

Bekhit

Hymete

Damtew

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Section: In Vivo Anti-malarial Activitymentioning

confidence: 99%

Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

Bekhit

Hymete

Damtew

et al. 2011

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

“…Moreover, control and treatment of these Plasmodium infections have been complicated as widespread resistance to the available antimalarial drugs such as chloroquine (Kalra et al 2006). So there is an urgent requirement for the search of alternative antimalarials to combat the resistance of the existing antimalarial drugs.…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

et al. 2013

View full text Add to dashboard Cite

In the present study of antimalarial efficacy, aqueous extracts of leaves and unripe fruits of Psidium guajava, leaves of Ocimum sanctum and leaves of Murraya koenigii are evaluated against Plasmodium berghei (chloroquine resistant NK65 strain) infected white albino BALB/c mice. A 7 days oral administration was adopted with different dosage viz., 350 mg, 750 mg and 1,000 mg/kg body weight as treatment schedule along with parasite (Group I) and drug control with Chloroquine, 50 mg/kg body weight (Group II). All the parts were extracted based on the decoction method, which is commonly seen among the villagers/tribes as their usual method of preparation of decoction for most of the ailments. The antimalarial activities were evaluated from the giemsa stained blood smears collected from different treated groups of mice used in this experiment. The antiplasmodial effect that is percent parasitaemia and percent suppression (values in parenthesis) showed by the treated groups of mice at 350 mg/kg b. wt. by the aqueous extracts of P. guajava leaves (Group III) was 19.8 ± 1.22 (73.7 %), P. guajava unripe fruits (Group IV) was 52.7 ± 2.19 (30.0 %), leaves of O. sanctum (Group V) was 64.0 ± 0.73 (15.1 %) and leaves of M. koenigii (Group VI) was 28.9 ± 0.81 (61.6 %) whereas at 750 mg/ kg b. wt., it all showed 10.3 ± 0.7 (80.2 %), 26.3 ± 0.52 (65.1 %), 42.0 ± 0.47 (44.2 %) and 14.9 ± 0.46 (71.5 %) whereas at 1,000 mg/kg b. wt. dose, it all showed 9.2 ± 0.39 (85.8 %), 25.6 ± 0.40 (62.0 %), 41.8 ± 0.29 (35.5 %) and 14.0 ± 0.42 (76.9 %) respectively. Keywords Medicinal plants ÁIn vivo antimalarial bioassay Á Mice Á P. berghei

show abstract

“…This was carried out using the Peter's 4-day suppressive test (Kalra et al, 2006). On day 0, the parasitemia and red blood cell count of the donor mice was determined by using a Giemsa-stained thin blood smear and an improved Neubauer counting chamber, respectively.…”

Section: In Vivo Schizontocidal Activitymentioning

confidence: 99%

Azadirachta indicaextract–artesunic acid combination produces an increased cure rate ofPlasmodium berghei-infected mice

Anagu

Attama²,

Okore³

et al. 2014

Pharmaceutical Biology

View full text Add to dashboard Cite

(Meliaceae).Objective: Combination of an artemisinin-based compound and a medicinal herb extract will provide an indigenous alternative/herb-based ACT. Materials and methods: The in vivo schizontocidal activity of the crude aqueous extract of 100, 500, and 1000 mg/kg of A. indica fresh leaves (NCE) and 6, 15, and 20 mg/kg of artesunic acid were determined, alone and in combination, while keeping the dose of artesunic acid constant at 15 mg/kg, using the Peter's 4-day suppressive test and Swiss albino mice. The ED 50 was calculated from the dose-response relationships. Percentage survival and cure were also determined. Results: The average yield of two extractions of NCE was 8.33 AE 1.67%. Combination of 1000 mg/kg of NCE and 15 mg/kg of artesunic acid, produced a significant reduction of parasitemia (96.87%), compared to 20 mg/kg of artesunic acid alone (68.14%). The combination had an ED 50 of 0.58 mg/kg while that of artesunic acid alone was 8.814 mg/kg. The combinations of NCE with artesunic acid produced a cure, although the artesunic acid did not produce a cure in 30 d. Discussion: NCE increased the activity of artesunic acid in terms of reduction in parasitemia, and increased survival time and cure rate. Conclusion: The combination of an artemisinin and aqueous extract of neem leaf is possible, providing a potentiated reduction of parasitemia, and increased cure rate.

show abstract

Screening of antimalarial drugs: An overview

Cited by 99 publications

References 38 publications

Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

Synthesis and biological screening of some pyridine derivatives as anti-malarial agents

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

Azadirachta indicaextract–artesunic acid combination produces an increased cure rate ofPlasmodium berghei-infected mice

Contact Info

Product

Resources

About