Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases

Auddy, B; Ferreira, Margot; Blasina, Fernanda; Lafon, L; Arredondo, Florencia; Dajas, Federico; Tripathi, Preeti; Seal, Tapan; Mukherjee, Biswajit

doi:10.1016/s0378-8741(02)00322-7

Cited by 340 publications

(197 citation statements)

References 16 publications

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“…Asdaq et al also reported that methanolic extract of this plant was safe up to 5 g/kg dose [24]. The aqueous plant infusions were found to be safe when tested in cytotoxicity study on PC12 cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test [10]. In our study, EESC and AESC showed no toxicity at tested dose of 2500 mg/kg.…”

Section: Discussionsupporting

confidence: 62%

“…This plant is already reported to have significant in vitro and ex vivo antioxidant property [10], anti-inflammatory and lipid lowering activities [11]. Besides, it is reported to be useful in the various nervous disorders such as unilateral paralysis, facial palsy [12], and Parkinson's disease [13][14][15][16] as mentioned in the Ayurvedic literature.…”

Section: S Cordifolia L (Family Malvaceae)mentioning

confidence: 99%

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Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Khurana

Sharma

Patil

et al. 2017

Asian J Pharm Clin Res

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Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC, respectively) was evaluated against scopolamine (Sco)-induced amnesia in mice. S. cordifolia L. is a well-know Ayurvedic plant which has been administered anciently for various nervous disorders including loss of memory. Female Swiss albino mice were used for Sco-induced amnesia model and acute toxicity study.Methods: Acute toxicity study was carried out to select safe and effective doses (50, 100 and 250 mg/kg; p.o.) of AESC and EESC for further pharmacological evaluation. The AESC and EESC at selected doses and donepezil (Dpl) (5 mg/kg; p.o.) were administered to different groups for consecutive 15 days. On 15 th day of treatment, Sco (0.4 mg/kg, intraperitoneally) was administered to different groups for induction of amnesia. Mice were subjected to transfer latency (TL) and step down latency (SDL) tests on the 16 th day to evaluate the effect of AESC and EESC on memory.Results: Sco treatment caused a significant increase in TL and decrease in SDL. The EESC significantly and dose dependently reversed the Sco-induced amnesia. The maximum effect was seen in EESC (100 mg/kg) treated group. This effect of EESC was comparable to the group treated with Dpl. The group treated with varying doses of AESC showed no significant effect on TL and SDL. Conclusion:These findings suggested the possible therapeutic potential of EESC (70%) for diseases related to memory dysfunctions like dementia in Alzheimer's disease.

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Section: Discussionsupporting

confidence: 62%

Section: S Cordifolia L (Family Malvaceae)mentioning

confidence: 99%

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Khurana

Sharma

Patil

et al. 2017

Asian J Pharm Clin Res

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“…Investigations on medicinal plants have reclaimed significance in the modern times due to their increasing comprehensive biological properties and emerging recognition of their origin, function and structural diversity [6] . Medicinal plants are receiving great attention because of their significant antioxidant potential, minimal adverse effects and economic affordability [7] . They contain a wide variety of chemical constituents, which may act individually or synergistically to cure diseases associated with oxidative stress and improve health [8] .…”

Section: Research Papermentioning

confidence: 99%

In vitro Evaluation of Antioxidant and Antiproliferative Activities of Artemisia nilagirica Extracts

Gul¹,

Bhat²,

Maurya³

et al. 2017

pharmaceutical-sciences

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“…The medicinal properties of plants have been investigated in the recent scientific developments throughout the world, due to their potent antioxidant activities, no side effects and economic viability (Auudy et al, 2003). Plant phytochemicals viz phenolic compounds, flavonoids and tannins reported to possess significant antioxidant activity against a wide variety of free radicals (Kirmizibekmez et al, 2009;Choudhary and Swarnkar 2011;Koleckar et al, 2008).…”

Section: Synthetic Antioxidants Like Butylated Hydroxytoluene (Bht)mentioning

confidence: 99%

Effects of Abeliophyllum distichum Nakai Flower Extracts on Antioxidative Activities and Inhibition of DNA Damage

Ahn¹,

Park²

2013

Korean Journal of Plant Resources

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-The present study attempts to evaluate antioxidant activities of extracts from Abeliophyllum distichum. Nakai flower. The samples were collected in Jangyyeon-myeon, Goesan-gun, Korea and extracted with either hot-water or ethyl acetate (EtOAC). In DPPH, hydroxyl radical scavenging activity and Fe 2+ chelating activity of EtOAC extracts were 93.41%, 98.43%, and 7.38%, while those of hot-water extracts were 86.93%, 41.33% and 47.68% at 200 μg/ml, respectively. In φX-174 RF I plasmid DNA cleavage assay, the protective effects of EtOAC and hot-water extracts against oxidative DNA damage were 82% and 17% at 200 μg/ml, respectively. Both extracts showed the protective effect of DNA migration by oxidative stress in intracellular DNA migration assay. Both extracts had no cytotoxity in NIH3T3 cells. Several polyphenolic compounds were identified such as 2-methoxy-benzoic acid, vanillic acid, phytol and pulegone by GC/MS. These results indicated that extracts of Abeliophyllum distichum Nakai flower showed antioxidant activities and protective activities against oxidative DNA damage and showed the possibility to be used as an effective natural antioxidants.

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Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases

Cited by 340 publications

References 16 publications

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

Ameliorative Effect of Sida Cordifolia L. Against Scopolamine-Induced Cognitive Deficit Mice Model

In vitro Evaluation of Antioxidant and Antiproliferative Activities of Artemisia nilagirica Extracts

Effects of Abeliophyllum distichum Nakai Flower Extracts on Antioxidative Activities and Inhibition of DNA Damage

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