Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities

Abstract

Objectives:Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models.Materials and Methods:Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50 mg/kg and 100 mg/kg.Results:The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100 mg/kg (i.p.) and was comparable to that of standard analgin (150 mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50 mg/kg and 100 mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5 mg/kg).Conclusion:Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

Analgesic Activity of Portulaca Oleracea Linn. In Experimental Animal Models

“…Pain and inflammation are an essential prelude to the repair process. 19 The Tail flick test is a standard model for evaluating central analgesic activity of a drug in albino rats. Pethidine (5 mg/kg) was used as standard drug in this study which was also used as a standard drug by other workers.…”

Study of analgesic activity of ethanol extract of Phlogacanthus thyrsiflorus on experimental animal models

“…Peripherally acting analgesics act by blocking the generation of impulses at chemoreceptor site of pain, while centrally acting analgesics not only raise the threshold for pain, but also alter the physiological response to pain and suppress the patient's anxiety and apprehension (Shreedhara et al, 2009). Pretreatment with naloxone significantly decreased the reaction time producing hyperalgesia while combined treatment consisting ethanol extracts of P. thyrsiflorus (500 mg/kg, p.o.)…”

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“…Different CNS depressant paradigms like analgesic activity (Eddy's hot plate method and acetic acid writhing method) were carried out following the intraperitoneal administration of extract at dose level 50 and 100 mg/kg. The dose of 100 mg/kg was comparable with standard drugs 35 . The ethyl acetate extract of stem bark of Bauhinia purpurea was found good analgesic activity tested at dose level 400 mg/kg by acetic acid induced writhing model and hot plate method 36 .…”