Screening of complex fucoidans from four brown algae species as procoagulant agents

Zhang, Zhenqing; Till, Susanne; Knappe, Sabine; Quinn, Catherine; Catarello, J.; Ray, G. Joseph; Scheiflinger, Friedrich; Szabo, Christina M.; Dockal, Michael

doi:10.1016/j.carbpol.2014.09.001

Cited by 25 publications

(9 citation statements)

References 45 publications

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“…The weight average molecular weight ( M w ), number average molecular weight ( M n ), and polydispersity ( R g ) values of extracted fucoidan were 1,021 ± 31.75, 806.15 ± 17.47, and 1.27 ± 0.03 kDa, respectively. The M w of the UAE‐extracted fucoidan was in the wide range of 170–1,360 kDa, reported for the fucoidans from L. japonica , Undaria pinnatifida , and Ecklonia maxima (Zhang et al, ). Algal species and their growing conditions as well as extraction techniques can affect the M w of different extracted fucoidans (Borazjani et al, ).…”

Section: Resultsmentioning

confidence: 67%

Ultrasound‐assisted extraction of sulfated polysaccharide from Nizamuddinia zanardinii: Process optimization, structural characterization, and biological properties

Alboofetileh

Rezaei

Tabarsa

et al. 2018

J Food Process Engineering

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Single-factor experiment and Box-Behnken design were used to evaluate and optimize the effect of extraction time (40, 50, and 60 min), ultrasonic power (100, 150, and 200 W), watersolid ratio (60, 70, and 80 mL/g), and extraction temperature (70, 80, and 90 C) on the recovery of fucoidan from Nizamuddinia zanardinii by ultrasound-assisted extraction method (UAE). The optimal extraction conditions were as follows: extraction time of 58 min, ultrasonic power of 196 W, water-to-raw-material ratio of 80 mL/g, and extraction temperature of 70 C. Under these conditions, the polysaccharide yield was 3.51%. Extracted fucoidan was composed of fucose (32.33%), galactose (29.95%), mannose (27.97%), xylose (6.56%), and glucose (3.19%).The UAE-extracted fucoidan had appreciable DPPH radical scavenging and reducing power. The fucoidan exhibited notable cell growth inhibition against HeLa (62.36%) and HepG 2 (56.83%) cancer cell lines, and induced RAW264.7 murine macrophage cells to release considerable amount of nitric oxide (41 μmol). Practical applicationsSeaweeds are rich sources of diverse bioactive compounds with valuable nutraceutical, pharmaceutical and cosmeceutical potentials. Nizamuddinia zanardinii is a marine brown seaweed and belong to Sargassaceae family. Iranian South Coasts have abundant supply of N. zanardinii which has a great potential for mariculture and can be utilized as a source of natural compounds. Fucoidan, which is a sulfated polysaccharide found in brown seaweeds, have shown promising health benefits for humans. In this study, the effects of extraction time, ultrasonic power, water-solid ratio, and extraction temperature were investigated on yield, structural, molecular, and biological properties of ultrasound extracted fucoidan. This study provides a practical and effective instruction into the application of ultrasound in the extraction of fucoidan. Additionally, the ultrasound extracted fucoidan exhibited appreciable antioxidant, anticancer, and macrophage-stimulating capacity indicating its potential value for health and food industry.

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Section: Resultsmentioning

confidence: 67%

Ultrasound‐assisted extraction of sulfated polysaccharide from Nizamuddinia zanardinii: Process optimization, structural characterization, and biological properties

Alboofetileh

Rezaei

Tabarsa

et al. 2018

J Food Process Engineering

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“…The size and DS of fucoidan has, for instance, shown to influence its procoagulant properties . As the structure of fucoidan from different seaweeds varies, its natural source also greatly affects its ability to activate platelets . For efficient application of fucoidan as molecular tools for studying processes associated with platelet activation, its structural reproducibility needs to be improved.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets

et al. 2016

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The marine sulfated polysaccharide fucoidan displays superior ability to induce platelet aggregation compared to other sulfated polysaccharides. As such, it is an attractive tool for studying molecular and cellular responses in activated platelets. The heterogeneous structure, however, poses a problem in such applications. This study describes the synthesis of sulfated α-l-fucoside-pendant poly(methacryl amides) with homogeneous structures. By using both thiol-mediated chain transfer and reversible addition-fragmentation chain transfer polymerization techniques, glycopolymers with different chain lengths are obtained. These glycopolymers show platelet aggregation response and surface changes similar to those of fucoidan, and cause platelet activation through intracellular signaling as shown by extensive protein tyrosine phosphorylation. As the platelet activating properties of the glycopolymers strongly mimic those of fucoidan, this study concludes these fucoidan-mimetic glycopolymers are unique tools for studying molecular and cellular responses in human blood platelets.

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“…1 Valuable compounds and nutrients such as carbohydrate, minerals, proteins and fatty acids are the reason for many of the algae species to be used as food as well as traditional remedies for many diseases. [2][3][4] . Some of the algae compounds have revealed biological and potential therapeutic properties such as anti-inflammatory, antibacterial, antiviral, cytotoxic and antimitotic activities.…”

Section: Introductionmentioning

confidence: 99%

Effect of Brown Algae Cystoseira trinodis Methanolic Extract on Renal Tissue

Gazor¹,

Pasdaran²,

Almasi³

et al. 2016

Pharm Sci

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Screening of complex fucoidans from four brown algae species as procoagulant agents

Cited by 25 publications

References 45 publications

Ultrasound‐assisted extraction of sulfated polysaccharide from Nizamuddinia zanardinii: Process optimization, structural characterization, and biological properties

Ultrasound‐assisted extraction of sulfated polysaccharide from Nizamuddinia zanardinii: Process optimization, structural characterization, and biological properties

Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets

Effect of Brown Algae Cystoseira trinodis Methanolic Extract on Renal Tissue

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