Screening of liver protective effect of ethanolic leaf extract of Callicarpa lanata (EECL) in ethanol induced hepatotoxicity in wister rats

Abstract

Background: The ethanolic extract of Callicarpa lanata (EECL), belonging to the family Verbenaceae, were studied for hepatoprotective activity in Wister rats with liver damage induced by ethanol.Methods: Ethanol treated rats showed significant increase in the levels of serum enzyme activities, total bilirubin and reduction in total proteins reflecting the liver injury caused by ethanol. EECL, at a dose of 400 and 200mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Alkaline Phosphate (SALP), Gama Glutamyl Transpeptidase (GGTP), total Bilirubin to a significant extent and also significantly increased the levels of total protein in a dose dependent manner.Results: The results were highly significant at dose level of 400mg/kg body weight (p <0.01) and significant at dose level of 200mg/kg body weight (p <0.05). The effects of EECL at both levels were comparable with standard drug silymarin. The hepatoprotective activity was also supported by histopathological studies of liver tissue.Conclusions: In-vivo hepatoprotective activity of ethanolic leaf extract of Callicarpa lanata (EECL) against Ethanol induced acute liver injury in rats showed significant results in a dose dependent manner.

Evaluation of Pharmacological Profiling of Albizia Odoratissima Bark Extracts on Ethanol-Induced Hepatotoxicity in Albino Rats

“…A total of twenty-four male albino rats were selected randomly and divided into four groups, six rats each (n=6). The animals received respective treatments orally through oral gavage for a period of 21 days 13 . Group-I (Normal control): Received only the CMC as vehicle.…”

Hepatoprotective activity of ethanolic and aqueous extract of Turnera aphrodisiaca leaves against CCl4-induced liver injury in rats

“…In recent studies, the animal models suggest that liver injury in chronic alcoholics is due to oxidative stress that leads to fibrosis and impaired liver functions and increased apoptosis. 3 Turnera aphrodisiaca ward (synonym T. diffusa Willd., family Turneraceae) is commonly known as damiana. The leaves of T. aphrodisiaca have been used traditionally as a stimulant, aphrodisiac, tonic, diuretic, nerve tonic, laxative and in kidney, menstrual and pregnancy disorders.…”