Screening of lovastatin from higher basidiomycetous fungi from NTCC, forest pathology discipline, Dehradun, India

Pandey, Vijay Vardhan; Varshney, V. K.; Kumar, Manoj; Kumari, Anuradha; Pandey, Amit

doi:10.22271/phyto.2018.v7.i6m.06

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…The detection and screening of the potentially produced lovastatin using molds were carried out by measuring the inhibition zone against Neurospora crassa and C.albicans, which was examined by employing the well method. Also, Pandey et al [18] determined the produced lovastatin by the disc diffusion and agar well diffusion methods during a bioassay experiment with N.crassa.…”

Section: Bioassay Of Lovastatin Detection Utilizing Calbicansmentioning

confidence: 99%

Optimization of Lovastatin Production from A Local Isolate of Aspergillus terreus A50 in Solid State Fermentation by Classical and Statistical Methods

AL-Sa’ady

Aziz

2020

eijs

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Lovastatin is one of the most important compounds that is produced from some filamentous fungi, being employed in the reduction of hypocholesterolemia. The results of screening, after the collection of seventy-three local fungal isolates from different areas, demonstrated that the local isolate Aspergillus terreus A50 was the best isolate for lovastatin production, with a concentration of 12.66 µg/ml, through the submerged fermentation. Lovastatin produced from A. terreus A50 showed antimicrobial activities against a Candida albicans isolate. Solid state fermentation (SSF) was the best system to produce the highest yield of lovastatin by A. terreus A50 as compared to the submerged fermentation (SmF) system, with and without agitation. The optimum conditions for lovastatin production by SSF were also determined. The parameters included carbon sources (wastes), carbon sources mixture, incubation temperature, and moisturizing solution, which are commonly used in classical procedures. The results showed that a higher lovastatin production of 102.321 µg/gm substrate was obtained in the culture containing wheat bran and oat bran (1:1 w:w), sodium acetate, moisture ratio of 1.2 v:w, pH 7, incubation temperature of 30 °C and incubation period of 6 days. Some of these parameters, including pH, incubation period, and moisture ratio were determined by utilizing the Response Surface Method (RSM) as a statistical approach.

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Section: Bioassay Of Lovastatin Detection Utilizing Calbicansmentioning

confidence: 99%

Optimization of Lovastatin Production from A Local Isolate of Aspergillus terreus A50 in Solid State Fermentation by Classical and Statistical Methods

AL-Sa’ady

Aziz

2020

eijs

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Urea regulates soil nematode population by enhancing the nematode-trapping ability of nematode-trapping fungi

Fa,

Shuaiyi,

Boonmee

et al. 2024

Sci Rep

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As the most abundant animal in the soil, nematodes are directly or indirectly involved in almost all soil ecological processes. Studying soil nematode population regulation is essential to understanding soil ecological processes. This study found urea combines nematode-trapping fungi to regulate the population of soil nematodes. In soil, compared with no urea, adding 0.2 mg/mL urea after applying Arthrobotrys oligospora and Dactylellina ellipsospora reduced the number of nematodes by 34.7% and 31.7%. Further, the mechanism of urea couple nematode-trapping fungi to regulate the nematode population was explored in the medium environment. The results showed that the addition of 0.2 mg/ml urea accelerated the trap formation of A. oligospora and D. ellipsosporas by 50% and 46.5%, and increased the yield of traps of A. oligospora and D. ellipsosporas by 39.5% and 40.6%, thus, the predatory efficiency of A. oligospora and D. ellipsospora on nematodes was increased by 34.2% and 32.7%. In conclusion, urea regulates the predation ability of A. oligospora and D. ellipsosporas to regulate the soil nematode population. This study deepens the understanding of the regulatory pathways of the soil nematodes but also provides a potential new strategy for harmful nematode bio-control.

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Screening of lovastatin from higher basidiomycetous fungi from NTCC, forest pathology discipline, Dehradun, India

Cited by 2 publications

References 19 publications

Optimization of Lovastatin Production from A Local Isolate of Aspergillus terreus A50 in Solid State Fermentation by Classical and Statistical Methods

Optimization of Lovastatin Production from A Local Isolate of Aspergillus terreus A50 in Solid State Fermentation by Classical and Statistical Methods

Urea regulates soil nematode population by enhancing the nematode-trapping ability of nematode-trapping fungi

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