Screening of Mango Leaves (Mangifera Indica L.) Varieties in Indonesia for Antibacterial Activity in Staphylococcus Aureus

Utami, Novi Fajar; Prasetyorini,; Khaerunissa, Rike; Pramitasari, Indria; Herbayani, Ade

doi:10.7897/2277-4343.110234

Cited by 2 publications

(5 citation statements)

References 12 publications

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Mechanism of action of alkaloids as an antibacterial is by way of interference with the components of the peptidoglycan of the bacterial cell and as a result, the lining of the cell walls are not fully formed which will lead to cell death and also by inhibiting the enzyme topoisomerase in bacterial cells and thus can strongly inhibit the nucleic acid synthesis and in turn bacterial growth. 35,36 The activity of flavonoids as an antibacterial agent is that they can damage the permeability of the cell walls of microbes. The functional protein binds to the DNA of cells thus can inhibit the growth of microbes.…”

Section: Discussionmentioning

confidence: 99%

“…Because the surface-active ingredient saponin is similar to detergent, it reduces the surface tension of the bacterial cell wall and damage membrane permeability or leakage of cells, it resulting in discharge of intracellular compounds. 36,37 The mechanism of antibacterial action of the triterpenoids is that they act by disrupting the cytoplasmic membrane by inhibiting peptidation of the growing peptidoglycan chain and also inhibiting enzymes for cell wall synthesis. 38 Steroid compound that can be found in the herbal extract may possessed antibacterial activity.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

et al. 2022

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Objective Mangrove (Aegiceras corniculatum) is an abundant natural marine resource of Indonesia, which can be explored for treating periodontal disease due to its potential as immunoregulatory, antibacterial, and antioxidant properties. Purpose To investigate the active compound from Indonesian mangrove leaf extract (A. corniculatum) (MLE) for developing a herbal-based mouthwash through in silico and in vitro studies. Materials and Methods Phytochemistry and liquid chromatography-high resolution mass spectrometry (LC-HRMS) were done to explore the active compounds in MLE. Chemistry screening and interaction, absorption, distribution, metabolism, and excretion (ADME), molecular docking simulation, and visualization of MLE active compounds as anti-inflammatory, antioxidant, and antibacterial were investigated in silico The inhibition zone of MLE against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Fusobacterium nucleatum (Fn) as periodontopathogenic bacterias was performed by diffusion method. Doxycycline 100 mg was used as a positive control, as a treatment group, there were five groups, namely 0%, 25%, 50%, 75%, and 100% MLE. Results Alkaloid, saponin, flavonoid, triterpenoid, steroid, tannin, and quinone were detected in MLE. A high concentration of (-)epicatechin and coumaric acid (CA) were found in MLE. MLE in 100% concentration has the most effective ability to inhibit Fn, Pg, Aa growth in vitro. (-)-Epicatechin has a higher negative binding affinity than CA that can enhance heat shock protein (HSP)-30, HSP-70, HSP-90, interleukin-10, and FOXP3 and also inhibit interleukin-6, peptidoglycan, flagellin, and dectin in silico. Conclusion MLE of A. corniculatum has antioxidant, anti-inflammatory, and antibacterial activities that can be a potential raw material for developing a herbal-based mouthwash.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

et al. 2022

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“…Mangiferin is widely distributed in higher plants where it provides protection against different forms of static and dynamic stresses including pathogenic microorganisms [ 20 ]. Moreover, preclinical in tubo studies have shown that the ethanolic fraction obtained from Mangifera indica leaves and kernel is a potential anti-acne agent due to its inhibition activity against C. acnes , as well as its potent free-radical scavenging and inhibitory effects on acne-related pro-inflammatory cytokines [ 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes

et al. 2022

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(1) Background: Preclinical studies report that the ethanolic fraction from Mangifera indica leaves is a potential anti-acne agent. Nevertheless, the biological activity of Mangifera indica leaves has scarcely been investigated, and additional data are needed, especially in a clinical setting, for establishing the actual effectiveness of Mangifera indica extract as an active component of anti-acne therapy. (2) Methods: The evaluation of the biological activity of Mangifera indica extract was carried out through different experimental phases, which comprised in silico, in vitro, ex vivo and clinical evaluations. (3) Results: In silico and in vitro studies allowed us to identify the phytomarkers carrying the activity of seboregulation and acne management. Results showed that Mangifera indica extract reduced lipid production by 40% in sebocytes, and an improvement of the sebum quality was reported after the treatment in analyses performed on sebaceous glands from skin explants. The evaluation of the sebum quantity and quality using triglyceride/free fatty acid analysis conducted on Caucasian volunteers evidenced a strong improvement and a reduction of porphyrins expression. The C. acnes lipase activity from a severe acne phylotype was evaluated in the presence of Mangifera indica, and a reduction by 29% was reported. In addition, the analysis of the skin microbiota documented that Mangifera indica protected the microbiota equilibrium while the placebo induced dysbiosis. (4) Conclusions: Our results showed that Mangifera indica is microbiota friendly and efficient against lipase activity of C. acnes and supports a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne.

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Screening of Mango Leaves (Mangifera Indica L.) Varieties in Indonesia for Antibacterial Activity in Staphylococcus Aureus

Cited by 2 publications

References 12 publications

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

Anti-Periodontopathogenic Ability of Mangrove Leaves (Aegiceras corniculatum) Ethanol Extract: In silico and in vitro study

Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes

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