Screening of medicinal plants from Suriname for 5-HT1A ligands: Bioactive isoquinoline alkaloids from the fruit of Annona muricata

5-Hydroxytryptamine1Areceptor binding activity of bisbenzyltetrahydroisoquinoline alkaloids fromPopowia odoardi

“…Structurally related isoquinoline derivatives, such as annonaine, nornuciferine, and asimilobine, isolated from the fruit of Annona muricata, have been shown to inhibit the binding of [ 3 H]rauwolscine to 5-HT 1A receptors in calf hippocampus (Figure 4). The IC 50 values for inhibition of receptor binding for annonaine, nornuciferine, and asimilobine were 3, 9, and 5 M, respectively (Hasrat et al, 1997b), which are close to the K i values of O-methyldauricine (1) (4.5 M) and popisidine (2) (5.8 M). In the functional assay, based on the inhibition of the accumulation of cAMP in NIH-3T3 cells stably transfected with 5-HT 1A receptor from human, the K i values for annonaine, nornuciferine, and asimilobine were estimated to be less than 10 M (Hasrat et al, 1997a).…”

Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats

“…The crushed seeds are used against internal and external parasites, head lice and worms. The bark, leaves, and roots are considered sedatives, antispasmodic, hypoglycemic, hypotensive, diuretics, neuralgia (Hasrat et al;1997). Phytochemically, many active compounds and chemicals have been found in A. muricata, as scientists have been studying its properties since the 1940s.…”

Molecular Modes of Action of Defensive Secondary Metabolites

“…Binding to 5-HT 1A Hasrat et al (1997) Asimilobine Aporphine Several Annonaceae, Nelumbonaceae, Magnoliaceae Serotonergic antagonist Shoji et al (1987), Hasrat et al (1997) Berberine and related alkaloids Agonist at 5-HT receptors, hallucinogenic Kebabian and Neumeyer (1994), Buckingham (1996) Cinchonidine and related alkaloids Kebabian and Neumeyer (1994), Buckingham (1996), Wink et al (1998b) Ergometrine Teuscher and Lindequist (1994), Buckingham (1996) Serotonin Indoleamine Many plants (stinging hairs), also in venoms of Cnidaria, molluscs, and arthropods and skin secretions of amphibia…”