Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats

Adewole, Stephen O.; Caxton-Martins, Ezekiel A.

doi:10.4314/ajbr.v9i3.48903

Cited by 93 publications

(102 citation statements)

References 68 publications

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“…Two kilograms of the air-dried leaves of the plant was milled into fine powder. The powdered leaf was macerated in ethanol and extracted twice, on each occasion with 5 l of 70% ethanol at room temperature for 48 h. The combined ethanol extract was concentrated in a rotary evaporator (Buchi Rotavapor R200) [6].…”

Section: Preparation Of Annona Muricata L Leaf Ethanol Extract (Amlee)mentioning

confidence: 99%

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Hypoglycemic and Hypolipidemic Effects of Annona Muricata L. Leaf Ethanol Extract

Sovia

Ratwita

Wijayanti³

et al. 2017

Int J Pharm Pharm Sci

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Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups. Conclusion:In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

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Section: Preparation Of Annona Muricata L Leaf Ethanol Extract (Amlee)mentioning

confidence: 99%

“…The nutrients in soursop leaves also believed to stabilize blood sugar level in the normal range that very useful for diabetics management [4]. Several studies have shown that Annona muricata leaf had antihyperglycemic activity and revealed regeneration of pancreatic islet [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Effects of Annona Muricata L. Leaf Ethanol Extract

Sovia

Ratwita

Wijayanti³

et al. 2017

Int J Pharm Pharm Sci

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show abstract

“…Penggunaan obat herbal cenderung meningkat dengan adanya pemikiran back to nature serta krisis berkepanjangan yang dapat mengakibatkan turunnya daya beli masyarakat terhadap obat modern [1]. Tanaman herbal memiliki efek terapi, namun juga memiliki efek samping toksik, sehingga khasiat dan cara penggunaan perlu diketahui oleh masyarakat [2]. Salah satu tanaman herbal yang berkhasiat obat adalah sirsak (Annona muricata Linn).…”

Section: Pendahuluanunclassified

INHIBITION TEST OF METHANOL EXTRACT FROM SOURSOP LEAF (Annona muricata Linn.) AGAINST Streptococcus mutans BACTERIA*

Jannah¹,

Husni²,

Nursanty³

2017

J. Nat.

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“…Sirsak (Annona muricata L.) adalah salah satu tanaman yang bermanfaat untuk mengatasi berbagai penyakit. Hasil riset menunjukkan bahwa sirsak mampu menyembuhkan sakit jantung, asma, masalah liver (hati), dan rematik (Widyaningrum, 2011) serta mampu menyembuhkan berbagai kanker maupun tumor (Adewole, 2006;Chang, 2003;Wu et al, 2001). Hal ini dimungkinkan karena sirsak mengandung tanin, alkaloid, dan flavonoid (Kardinan, 2004).…”

Section: Pendahuluanunclassified

PROFIL KADAR MDA PADA TUMOR KULIT MENCIT (Mus musculus) SEBAGAI AKIBAT PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) DAN EKSTRAK METANOL BENALU TEH (Scurulla atropurpurea Bl. Dancer)

Holil

2013

el–Hayah

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Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats

Abstract: ABSTRACT

Cited by 93 publications

References 68 publications

Hypoglycemic and Hypolipidemic Effects of Annona Muricata L. Leaf Ethanol Extract

Hypoglycemic and Hypolipidemic Effects of Annona Muricata L. Leaf Ethanol Extract

INHIBITION TEST OF METHANOL EXTRACT FROM SOURSOP LEAF (Annona muricata Linn.) AGAINST Streptococcus mutans BACTERIA*

PROFIL KADAR MDA PADA TUMOR KULIT MENCIT (Mus musculus) SEBAGAI AKIBAT PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) DAN EKSTRAK METANOL BENALU TEH (Scurulla atropurpurea Bl. Dancer)

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