Hypoglycemic and Hypolipidemic Effects of Annona Muricata L. Leaf Ethanol Extract

Abstract

Objective: The aim of this study was to investigate hypoglycemic and hypolipidemic effects of Annona muricata leaf ethanol extract. This study also investigated phytochemical analysis of the extract and improvement in the islet of Langerhans.Methods: Hypoglycemic and hypolipidemic effects were evaluated using alloxan induced diabetic rats. Twenty-five Wistar rats devided into five groups, that are normal group, control group that induced by alloxan 125 mg/kg body weight and given CMC (carboxymethyl cellulose), and three treatment group that induced by alloxan and given Annona muricata leaf ethanol extract (AMLEE) with 50, 100 and 200 mg/kg body weight. Blood glucose and total cholesterol levels were measured before and after alloxan induction, and 21 d after AMLEE treatment. At the end of the study, all of the animals experiment were sacrificed for histopathological examination.Results: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of Annona muricata L. leaf. At the end of the study, blood glucose and total cholesterol levels in all AMLEE treated group were decreased significantly (p<0.05). Final blood glucose level in the groups that given AMLEE 50 mg/kg body weight (86.7±14.6 mg/dl) was almost the same with that of the normal group (91.25±28.38 mg/dl). The result of the histopathological examination is not showed an improvement of the islet of Langerhans in AMLEE treated groups. Conclusion:In conclusion, the ethanol extract of Annona muricata L. leaf have hypoglycemic and hypolipidemic effects. However, there was no improvement in the islet of Langerhans damage.

Evaluation of spermatogenic activity of Annona muricata methanolic bark extract in Albino rats

“…Sperm motility relies on the coordinated propagated flagella wave that is under the influence of acetylcholinesterase [12]. The spermatozoa motility is energy dependent, fueled by fructose and glucose oxidation, so reduction in the progressive sperm motility of the treated rats seen in this study could be due to the acetylcholinesterase inhibition and hypoglycemic properties of the specie of this plant as reported Sovia et al [13]. The significant decrease in the sperm concentration supported by the various degrees of degeneration in the histologic sections of the testis, suggests that Annona muricata methanolic bark extract is capable of permeating the blood-testis barrier [14].…”

Ameliorative Effect of Annona muricata (Graviola) Extract on Hyperglycemia Induced Hepatic Damage in Type 2 Diabetic Mice

“…Chronic hyperlipidemia in T2DM leads to an abnormal hepatic lipid metabolism and causes excess fat to accumulate, ultimately leading to NAFLD [38]. In previous studies, AME supplementation alleviated dyslipidemia in T2DM, especially through lowering hepatic triglycerides and plasma LDL cholesterol levels [25,38,39]. In accordance with the previous studies, this study demonstrated that, low dose of AME supplementation significantly reduced the hepatic TG concentration in the T2DM mice.…”

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

“…Muricata Annona L. (Graviola), a member of the Annonaceae family, is a perennial tree species used as herbal medicine. The plant has various pharmacological functions, including cytotoxicity, antimicrobial, and wound care [14]. It has antidiabetic and hypolipidemic [15], antiarthritic [16], antinociceptive [17], hepatoprotective and bilirubin-lowering [18], powerful antioxidants activities [19], antihypertensive [20], anticancer [21], gastroprotective [22], and anti-inflammatory and anticonvulsant [23] effects.…”