Screening of the topical anti-inflammatory activity of some Central American plants

Sosa, Silvio; Balick, Michael J.; Arvigo, Rosita; Esposito, Roberta; Pìzza, Cosimo; Altinier, G.; Tubaro, Aurelia

doi:10.1016/s0378-8741(02)00080-6

Cited by 178 publications

(140 citation statements)

References 15 publications

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“…Inflammation is an important pathological process of many diseases, and is the most common biological reaction to a variety of stimuli, infection, tissue injury and local injury (Banasik, 2000;Sosa et al, 2002). It is reported that inflammatory reactions can be triggered by physical or chemical trauma, invading organisms and antigen-antibody reactions.…”

Section: Introductionmentioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

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Section: Introductionmentioning

confidence: 99%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

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“…Although, there is a defense mechanism, the complex events and mediators involved in the infl ammatory reaction can induce, maintain or aggravate many diseases (Sosa et al, 2002). The non steroidal antiinfl ammatory drugs (NSAIDs) are one of the categories of drugs most frequently used by population.…”

Section: Introductionmentioning

confidence: 99%

“…However, for many of the plants in use, the real effi cacy and the relevant active principles are unknown. Consequently, experimental studies aimed at demonstrating the pharmacological properties of these plants and identifying the relevant active principles are needed (Sosa et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Review of the plants with anti-inflammatory activity studied in Brazil

Falcão¹,

Lima²,

Santos³

et al. 2005

Rev. bras. farmacogn.

119

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ABSTRACT:The infl ammatory reaction is a response of the organism against an injury and it involves the action of complex events and mediators through of the blood vessels. The present work is a literature survey of the extracts of plants with anti-infl ammatory activity studied in Brazil. The review refers to 75 plants with their families, parts used, type of extract used, bioassay models and their activity.

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“…The complex events and mediators involved in the inflammatory reaction can induce or aggravate many reactions [3][4][5]. According to the WHO report, about 70-80% of the world's population depend on nonconventional medicine predominantly from herbal sources in their primary health care [6,7]. Especially, in developing nations where the cost of consulting a physician and fee of medicine are beyond the edge of most people, thereby the demand is increasing day by day.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Zingiber Officinale on Sprague Dawley Rats

Karunakaran

Hassan²,

A³

et al. 2017

Asian J Pharm Clin Res

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Objective: To investigate the anti-inflammatory effect of aqueous extract of Zingiber officinale on carrageenan-induced inflammation on Sprague Dawley (SD) rats.Methods: SD rats were divided into six of five groups and allowed to acclimatize for 1 week. Inflammation was induced on the animal by injecting the right hand paw with carrageenan (0.1 ml of 1%). Group 1 was given normal saline and served as a control. Group 2 was fed with food and water and served as the carrageenan control. Group 3 was given 200 mg/kg aqueous extract of ginger, Group 4 with 400 mg/kg aqueous extract of ginger, and Group 5 with 150 mg/kg diclofenac sodium (reference drug for inflammation). Results:The paw edema in carrageenan-induced SD rats was considerably reduced by treating with 400 mg/kg aqueous ginger extracts when compared to the untreated SD rats (p<0.001). Conclusion:This study indicates that aqueous extract of Z. officinale possesses anti-inflammatory properties.

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Screening of the topical anti-inflammatory activity of some Central American plants

Cited by 178 publications

References 15 publications

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Review of the plants with anti-inflammatory activity studied in Brazil

Anti-Inflammatory Effect of Zingiber Officinale on Sprague Dawley Rats

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