Screening plant derived dietary phenolic compounds for bioactivity related to cardiovascular disease

Croft, Kevin D.; Yamashita, Yoko; O'Donoghue, Helen; Shirasaya, Daishi; Ward, Natalie C.; Ashida, Hitoshi

doi:10.1016/j.fitote.2017.12.002

Cited by 36 publications

(19 citation statements)

References 29 publications

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“…Due to the aromatic nature and highly conjugated systems with multiple hydroxyl groups, these compounds have beneficial electron or hydrogen atom donors, which neutralize free radicals and other reactive oxygen species. Each phenolic compound exhibits an antioxidant effect (Zhang et al, 2018), achieved by hydrogen supply and chelation of metal ions; an anticancer effect (Lee et al, 2016), primarily through antioxidant functions; the ability to prevent cardiovascular disease (Croft et al, 2018), which regulates blood lipid density in the blood, inhibits the oxidation of low-density lipoprotein, and promotes vasodilation, thereby achieving cardiovascular protection. (Hayes, Allen, Brunton, O'Grady, & Kerry, 2010).…”

Section: Discussion and Con Clus I On Smentioning

confidence: 99%

Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from Lonicera japonica

Fan

Lü

Bai

et al. 2019

Food Science & Nutrition

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The objective of this research was twofold: first, to optimize the extraction process of Lonicera japonica polyphenols using a response surface methodology, and second, to study the antioxidant activity and tyrosinase inhibitory capacity of the polyphenols of different purities. High‐speed shearing homogenization extraction was used to extract the polyphenols from L. japonica . The antioxidant activity and the effect of polyphenols on tyrosinase activity were studied using free radical scavenging assay and the tyrosinase method, respectively. The optimal extraction conditions with an extraction yield of 6.96% for polyphenols were determined as follows: ethanol volume fraction 57%, shearing time 3.30 min, and solid–liquid ratio 1:58. Lonicera japonica polyphenols exhibited potent scavenging activity on 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2, 2'‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), and inhibitory capacity on tyrosinase. The results suggested that L. japonica polyphenols could be explored as a natural antioxidant and tyrosinase inhibitor.

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Section: Discussion and Con Clus I On Smentioning

confidence: 99%

Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from Lonicera japonica

Fan

Lü

Bai

et al. 2019

Food Science & Nutrition

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“…Several health-promoting properties have been widely attributed to plant polyphenols, turning them in biomolecules for medicinal interest. 1,2 These molecules are chemically diversified and lead to new medical trends through their mechanism of action in exerting their antiproliferative, 3 anti-inflammatory processes 4 and antibacterial infections. 5 In order to corroborate the pharmacological bioactivities attributed to these compounds, they are chemically characterized using sophisticated analytical techniques, with high resolution and sensitivity to identify and quantify with high precision groups of compounds present in different samples.…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts ofZizyphus lotus(L.) Desf.

et al. 2019

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“…Anthocyanidins are essentially found on the skin of fruits and vegetables but have crucial functions in suppressing CVD bioactive properties [14]. Hyperglycemia can lead to diabetes and eventually lean towards endothelial dysfunction causing CVD [19]. A polyphenol called caffeic acid, which are mainly found in coffee, has been associated with glucose metabolism and improving vascular function.…”

Section: Endothelial and Arterial Functionmentioning

confidence: 99%

“…Overall, the dihydroferulic acid showed better effects on improving cellular uptake of GLUT4 regulating glucose metabolism and decrease CVD risk. However, more research is needed because the study experimented in-vitro and there is inadequate information in the actual in-vivo bioactivity of dihydroferulic acid [19]. Arterial stiffness is one of the precursors of CVD risk factors and is a reversible process by enhancing dietary changes especially in polyphenol-rich fruits and vegetables [20].…”

Section: Endothelial and Arterial Functionmentioning

confidence: 99%

Benefits and Preparation Effects on Polyphenol-Rich Fruits and Vegetables Towards Cardiovascular Disease Prevention

Hawana¹,

Alraei²

2019

J Nutr Food Sci

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Individuals with cardiovascular disease are advised to consume fruits and vegetables due to their potential health benefits of their polyphenol-rich components. The main precursors that lead to cardiovascular disease are endothelial dysfunction and arterial stiffness. These metabolic dysfunctions can be improved by bioavailability of polyphenol-rich foods such as hesperidin from citrus fruits or anthocyanidins that give the color of fruits and vegetables. Polyphenolrich foods can increase beneficial biological processes including the expression of nitric oxide in the blood vessel to enhance vascular tone by vasodilation. However, polyphenols can be lost during absorption and post-absorption by interactions with other macromolecules. Additionally, the cooking methods and preparation of certain polyphenol-rich fruits and vegetables can cause extreme loss of polyphenols. Recent studies have demonstrated various cooking methods that can enhance the nutrient quality of polyphenols and their bioavailability. Understanding the absorption, biological processes and cooking methods of polyphenol-rich fruits and vegetables can help link the benefits of prevention or treatment in cardiovascular disease risk factors.

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Screening plant derived dietary phenolic compounds for bioactivity related to cardiovascular disease

Cited by 36 publications

References 29 publications

Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from Lonicera japonica

Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from Lonicera japonica

HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts ofZizyphus lotus(L.) Desf.

Benefits and Preparation Effects on Polyphenol-Rich Fruits and Vegetables Towards Cardiovascular Disease Prevention

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