Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens

Vonshak, Avigad; Barazani, Oz; Sathiyamoorthy, P.; Shalev, R; Vardy, Daniel; Golan‐Goldhirsh, Avi

doi:10.1002/ptr.1399

Cited by 67 publications

(30 citation statements)

References 5 publications

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“…Pre-treatment with T. cordifolia was to impart protection against mortality induced by intraabdominal sepsis following coecal ligation in rats (Singh et al 2003). C. paniculatus exhibited anti-fungal activity against six species of fungi (Trichophyton mentagrophytes, T. rubrum, T. soudanense, C. albicans, Torulopsis glabrata and C. krusei (Vonshak et al 2003). The aqueous extract of C. paniculatus seed has cognitiveenhancing properties and an antioxidant effect (Kumar and Gupta 2002).…”

Section: Resultsmentioning

confidence: 98%

Antifungal and high-performance liquid chromatography analysis of the crude extracts ofAcorus calamus, Tinospora cordifoliaandCelestrus paniculatus

Singh¹,

Srivastava²,

Choudhary³

2011

Archives Of Phytopathology And Plant Protection

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The antifungal activity of methanolic crude extracts of Acorus calamus, Tinospora cordifolia and Celestrus paniculatus was investigated against Alternaria solani, Curvularia lunata, Fusarium sp., Bipolaris sp. and Helminthosporium sp. at different concentrations (1000, 2000, 3000, 4000 and 5000 mg/ml). At 5000 mg/ml, crude extract of T. cordifolia is found to be highly effective against Helminthosporium sp. followed by A. calamus against A. solani. On the other hand, at 5000 mg/ml, C. paniculatus showed better activity against A. solani and Helminthosporium followed by A. calamus against A. solani at 4000 mg/ml. At 5000 mg/ml, all the three crude extracts showed least activity against fungus C. lunata and Fusarium sp. except A. calamus that showed better activity against C. lunata. The increase in the production of phenolic acid in the extract can be correlated with the induction of resistance in treated plants against phytopathogenic fungi. High-performance liquid chromatography analysis of the crude extract of medicinal plants showed six different phenolic acids (benzoic acid, cinnamic acid, caffeic acid, ferulic acid, gallic acid and tannic acid) present in varying amounts. The results of the study provide scientific basis for the use of the plant extract in the future development as antioxidant, antibacterial, antifungal and anti-inflammatory agent.

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Section: Resultsmentioning

confidence: 98%

Antifungal and high-performance liquid chromatography analysis of the crude extracts ofAcorus calamus, Tinospora cordifoliaandCelestrus paniculatus

Singh¹,

Srivastava²,

Choudhary³

2011

Archives Of Phytopathology And Plant Protection

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“…Thus there is an urgent need for safer and more effective antifungal agents, and considerable resources are being channelled into the search for new agents (Dannaoui et al, 2001). Much effort has been undertaken in the area of medicinal plants to obtain therapeutic agents from natural sources (Vonshak et al, 2003). Diospyros is numerically and economically the most important genus of Ebenaceae, many species of which have been reported to exhibit interesting biological activities (Masami et al, 2003;Adeniyi et al, 2000).…”

Section: Introductionmentioning

confidence: 98%

In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)

Dzoyem

Tangmouo

David

et al. 2007

Phytotherapy Research

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In this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78-3.12 microg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent.

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“…In addition, a prodrug activity for treatment of cardiovascular disorders has been described (9)(10)(11)(12)(13)). An aqueous seed extract of Terminalia chebula Retzius (TcRSE) exhibits in vitro antioxidant and free radical-scavenging behavior, and has potent antimicrobial, anticancer, antiviral, and anti-diabetic effects either in vitro or in vivo (14).…”

Section: Discussionmentioning

confidence: 99%

“…Terminalia chebula Retzius is an ethnopharmacological plant of India and Southeast Asia, and has traditionally been used as a laxative, a diuretic, and an anti-oxidative material (4)(5)(6)(7)(8). In addition, plant extracts have antibacterial (9,10), antiviral (11), antifungal (12) and immune modulatory activities (13,14). Recently, Lee et al (5,15) reported that an aqueous seed extract of Terminalia chebula Retzius (TcRSE) had potent anti-oxidant activity both in vitro and in vivo when tested as a hepatoprotective agent in an animal model.…”

Section: Introductionmentioning

confidence: 99%

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

Lee¹

2011

Int J Mol Med

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Abstract.To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4 + cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model. The data showed that a Terminalia chebula extract (100 µg/ml) exhibited strong anti-atopic activity, mediating a 52% reduction in the immune response, as measured by thickness of ear swelling, and resulting in decreased eosinophil levels in adjacent skin tissue. Collectively, the results indicate that a Terminalia chebula seed extract has potential for alleviation of atopy-like symptoms induced by DNFB in the mouse. IntroductionIt is generally accepted that the daily consumption of plantderived phytochemicals in vegetables, fruit, tea or herbal extracts may mitigate free-radical attacks (1-3). Terminalia chebula Retzius is an ethnopharmacological plant of India and Southeast Asia, and has traditionally been used as a laxative, a diuretic, and an anti-oxidative material (4-8). In addition, plant extracts have antibacterial (9,10), antiviral (11), antifungal (12) and immune modulatory activities (13,14). Recently, Lee et al (5,15) reported that an aqueous seed extract of Terminalia chebula Retzius (TcRSE) had potent anti-oxidant activity both in vitro and in vivo when tested as a hepatoprotective agent in an animal model. Atopic dermatitis is a major degenerative disease, which presents as a chronic inflammatory skin condition with a deficiency in barrier function (16). It is now well recognized that several proteases, including the matrix metalloproteinases (MMPs), play key roles in the immunopathology of and biological functions during progression of the disease (17). With limited exceptions, normal healthy skin does not contain or exhibit high levels of MMP activity. Thus, evaluation of enzyme activities is important in detection, prior to mitigation, of allergic reactions (18,19). However, little effort has been devoted to treatment of atopy-related disorders with natural extracts, and we thus prioritized the investigation of TcRSE as an inhibitor of anti-atopic dermatitis activity.In the present study, we initially sought immunomodulatory components in natural resources including foods and oriental herbs, and found that TcRSE was active in vitro (data not shown). We thus examined the ameliorating effects of TcRSE against 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis in mice. Biochemical and immunochemical analyses, including cytokine expression evaluation and phenotypic atopic symptoms, were performed to investigate whether TcRSE alleviated the disorder. Materials and methodsChemicals. MMP-9, anti-T-bet and interleukin (IL)-31 antiinterleukin (IL)-31 anti-IL)-31 antibodies were purchased from Cell Signaling (catalog no. 3852; Danvers, MA), Santa Cruz ...

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Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens

Cited by 67 publications

References 5 publications

Antifungal and high-performance liquid chromatography analysis of the crude extracts ofAcorus calamus, Tinospora cordifoliaandCelestrus paniculatus

Antifungal and high-performance liquid chromatography analysis of the crude extracts ofAcorus calamus, Tinospora cordifoliaandCelestrus paniculatus

In Vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)

Mitigation of 2,4-dinitrofluorobenzene-induced atopic dermatitis-related symptoms by Terminalia chebula Retzius

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