Screening the receptorome

Abstract

The term 'receptorome' is now being used to describe receptors, ion channels and transporters in the human genome that are potential drug targets. These proteins comprise a considerable fraction of the human genome, and include the G protein-coupled receptors, which are the targets for many medications. In this review, we summarize recent advances in the field, including the concept that the ultimate goal of drug discovery may not be the development of highly selective single-target drugs, the idea that potential side-effects can also be the goal of multi-target drug screening, and a discussion of the application of computational screening and public domain databases available to interested investigators.

Planar versus mesoscopic perovskite microstructures: The influence of CH3NH3PbI3 morphology on charge transport and recombination dynamics

“…TRMC is recognised as a powerful technique to analyse both transport and recombination kinetics in hybrid organic-inorganic photovoltaic technologies. [17][18][19] Through this technique, changes in the microwave absorption, ∆P(t), with respect to the steady-state power of the microwave beam, P, are related to the photoconductance of a material, ∆G(t), by        G t K P t P , when the sample is excited with a 5 ns laser pulse.…”

“…[20] The photoconductance is proportional to the density of excited charge-carriers as a function of time, and the corresponding mobility of these carriers. For a given material, one of the figures-of-merit typically extracted from TRMC measurements is the product of the quantum efficiency for free carrier generation per photon absorbed during the pulse, φ, and the sum of the mobilities of these carriers, ∑μ, given by: [17]…”

“…As noted above, for materials with high dielectric constants, φ = 1 and the data of Figure 3 can be directly interpreted as the sum of mobilities of electron and holes. [23] For this system, there is strong evidence to suggest that the microwave transients are dominated by an electron signal. [21] Mobilities relating to the planar films are shown in the circles and those relating to the mesoscopic devices are shown in the triangles.…”

Role of pharmacogenetics in the use of CNS drugs: from drug pipeline to primary care?

“…Until advances in gene cloning started to reveal more about the genetics of neurotransmission, the brain had remained a blackbox, in which the modes of action of some pharmacological compounds were largely unknown. The hope now is that brain function and disease will be increasingly understood in detailed molecular terms, as functional genomics and neuroscience research support advances in pathophysiology [4,5]. Furthermore, with clearer understanding of interindividual variation in molecular structures of drug receptors, transporters or metabolizing enzymes, predictive tests will facilitate reduced occurrence of toxicity and nonresponse in the clinic.…”

Receptomics, design of a microfluidic receptor screening technology

“…The term receptomics was first coined in 2004 to describe the systematic study of the receptorome, i.e. the collection of receptors and ligand-gated ion channels that serve as sensors and potential drug targets [101,102]. Covering an estimated 8% of the total human genome [101] this protein class is significantly represented.…”