Screening women at high risk for breast cancer with mammography and magnetic resonance imaging

Lehman, Constance D.; Blume, Jeffrey D.; Weatherall, Paul T.; Thickman, David; Hylton, Nola; Pisano, Etta D.; Schnitt, Stuart J.; Gatsonis, Constantine; Schnall, Mitchell D.

doi:10.1002/cncr.20971

Cited by 356 publications

(199 citation statements)

References 10 publications

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“…[11] reporting only 2.9% and [12] [13] reporting biopsy procedures with percentages of just over 15%. Also, it was elsewhere mentioned [2] where the range was 6.3% similar to prior studies ranging (from 2.9% to 15.8%) among Screening Women at High Risk for Breast Cancer with Mammography and Magnetic Resonance Imaging.…”

Section: Discussionsupporting

confidence: 84%

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

Garout¹,

Ahmed²,

Jastaniah³

et al. 2014

ABCR

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MRI is an excellent option for detection of breast cancer for some selected groups, including those patients with a high probability to hit the disease. However, the high costs and low availability of the device have led to a decline in the application of imaging MRI. The aim of this study was to review usefulness of MRI as a new complementary way to detect breast cancer in routine annual checkup for women breasts of certain ages and breast mass. A cross-sectional Descriptive MRI study was performed on 105 asymptomatic women with a mean age of 49 years. The study group with at least one risk factor of breast cancer were presenting for routine annual screening or follow up at King Abdulaziz University Hospital in Jeddah. It has been found that, 48 patients had biopsy, they were recommended by magnetic resonance imaging and only 14 had positive results, while magnetic resonance imaging suggested 16 and mammography had 62 positive results. Magnetic resonance imaging is not recommended for the average-risk or the general population either; it had been advised for screening the high-risk women of breast cancer. Sensitivity of magnetic resonance imaging has been found to be much higher than of mammography but specificity was generally lower. We propose that it is reasonable to consider MRI as a complement to mammography in screening patients who were at high risk for breast cancer because Magnetic Resonance Imaging can detect small foci that are occult in mammography but we don't advise to check with the general population.

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Section: Discussionsupporting

confidence: 84%

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

Garout¹,

Ahmed²,

Jastaniah³

et al. 2014

ABCR

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show abstract

“…The reported data further indicate that 18 F-FDG PET/CT mammography may be more accurate than MRI mammography in pretherapeutically differentiating breast lesions as unifocal, multifocal, or multicentric. MRI has been known to be a sensitive but less specific modality when it comes to detection and characterization of breast cancer lesions (32)(33)(34)(35). Six cases were falsely rated as multicentric with MRI in the current study.…”

Section: Discussionmentioning

confidence: 59%

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Heusner¹,

Küemmel²,

Umutlu³

et al. 2008

J Nucl Med

104

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“…Breast cancer detection is still principally based on mammography, which misses about 10% of breast carcinomas (25)(26)(27)(28) because of dense breast tissue. Breast MRI has been shown to be highly effective in identifying occult tumor, but FP findings may occur (6,(29)(30)(31)(32)(33)(34). As both MRI and PET/CT are frequently requested for disease evaluation for suspected breast cancer, a mechanism to foster direct comparison of lesions detected with both modalities would be useful (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

Moy

Ponzo²,

Noz³

et al. 2007

Journal of Nuclear Medicine

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MRI is a sensitive method for detecting invasive breast cancer, but it lacks specificity. To examine the effect of combining PET with MRI on breast lesion characterization, a prototype positioning device was fabricated to allow PET scans to be acquired in the same position as MRI scans-that is, prone. Methods: To test the hypothesis that fusion of 18 F-FDG PET and MRI scans improves detection of breast cancer, 23 patients with suspected recurrent or new breast cancer underwent a routine whole-body PET scan, a prone PET scan of the chest, and a routine breast MRI scan. The attenuation-corrected prone PET and MRI datasets were registered twice by different operators. The fusion results were judged for quality by visual inspection and statistical analysis. A joint reading of the MRI and PET scans side by side and integrated images was performed by a nuclear medicine physician and a radiologist. Sensitivity and specificity of MRI and combined MRI and PET scans were calculated on the basis of pathology reports or at least 1 y of clinical and radiologic follow-up. Results: All fusions were verified to be well matched using specific anatomic criteria. A total of 45 lesions was assessed. Lesion size range was 0.6 to 10.0 cm. Of the 44 breasts examined, 29 were suspicious for cancer, of which 15 were found to be positive on surgical excision. In lesion-by-lesion analysis, sensitivity and specificity of MRI alone were 92% and 52%, respectively; after MRI and PET fusion, they were 63% and 95%, respectively. The positive predictive value and the negative predictive value for MRI alone were 69% and 85%, respectively; after MRI and PET fusion, they were 94% and 69%, respectively. Conclusion: Acquisition of prone PET scans using the new positioning device permitted acquisition of prone scans suitable for fusion with breast MRI scans. Fused PET and MRI scans increased the specificity of MRI but decreased the sensitivity in this small group of patients. Additional data are needed to confirm the statistical significance of these preliminary findings.

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Screening women at high risk for breast cancer with mammography and magnetic resonance imaging

Cited by 356 publications

References 10 publications

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

Magnetic Resonance Imaging for Screening of Woman at High-Risk of Breast Cancer

Breast Cancer Staging in a Single Session: Whole-Body PET/CT Mammography

Improving Specificity of Breast MRI Using Prone PET and Fused MRI and PET 3D Volume Datasets

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