Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

Wang, Jun; Chen, Shanshan; Zhang, Jizhou; Wu, Jiasi

doi:10.3389/fphar.2022.946030

Cited by 14 publications

(12 citation statements)

References 85 publications

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“…Scutellaria baicalensis (Huang Qin, baicalin and baicalein): This herb, known for its anti-inflammatory and neuroprotective effects, has been reported to improve MS symptoms by modulating the gut microbiota (Wang et al 2022b ).…”

Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gut microbiota and the central nervous system, that can influence neurodegenerative diseases (NDs). Indeed, imbalances in the gut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbal medicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptoms and delay the progression of NDs by improving intestinal barrier function, reducing neuroinflammation, and modulating neurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiota in the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeutic strategies for NDs. In this review, we investigate the potential neuroprotective effects of herbal medicine, focusing on its ability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research priorities of the integration of herbal medicine and modern medicine. As the global population ages, access to this information is becoming increasingly important for developing effective treatments for these diseases.

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Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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“…In the treatment of RA, Baicalin has a good curative effect and few adverse reactions, and can improve the symptoms of RA rats. 50 Baicalin adjusts the Th17/Treg immune equilibrium in CIA rats by inhibiting JAK/STAT3 signaling activation and transferring it to Treg cells, thereby ameliorating arthritis symptoms in rats. 51 In summary, these Chinese herbal monomers or active components can adjust the equilibrium of Th17/Treg cells by interfering with cytokines, transcription factors, and signaling pathways, inhibiting the immunoreaction and maintaining immune homeostasis, improving RA symptoms and reducing bone destruction (Table 1).…”

Section: Th17/ Treg Cell Imbal An Ce and R Amentioning

confidence: 99%

“…Baicalin, a flavonoid in the root of Scutellaria baicalensis Georgi, can inhibit inflammation and regulate immune function. In the treatment of RA, Baicalin has a good curative effect and few adverse reactions, and can improve the symptoms of RA rats 50 . Baicalin adjusts the Th17/Treg immune equilibrium in CIA rats by inhibiting JAK/STAT3 signaling activation and transferring it to Treg cells, thereby ameliorating arthritis symptoms in rats 51…”

Section: Traditional Chinese Medicine Regulates the Equilibrium Of Th...mentioning

confidence: 99%

The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis

Wang

et al. 2023

Int J of Rheum Dis

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Rheumatoid arthritis (RA) is a persistent systemic autoimmune disease, having all the hallmarks of joint swelling, joint tenderness, and progressive joint destruction, with synovitis and pannus formation as the basic pathological changes. T‐lymphocyte infiltration is the key to its pathogenesis. During the growth of RA, the share of regulatory T (Treg) cells decreases, while the percentage of T helper type 17 (Th17) cells increases, giving rise to an imbalance of Th17/Treg cells. Modern medicine has made great advances in the treatment of RA and the selection of available drugs, but there are also the disadvantages of gastrointestinal reaction, high price, and low patient compliance. Therapy of RA remains a problem. Traditional Chinese medicine (TCM) has RA therapy developments, both in experimental research and clinical research, and its advantages of lasting effects and less detrimental reactions and fewer adverse effects are accepted by most patients. Numerous clinical and experimental studies have been performed in TCM on regulating Th17/Treg balance. However, the detailed mechanism of TCM intervention in Th17/Treg equilibrium in preventing and treating RA has not been discovered. In this article, the theory of regulating Th17/Treg cell equilibrium in RA is described from the perspectives of single Chinese medicine, active components of Chinese medicine, Chinese medicine compounds, and other therapies of TCM. It was found that TCM can regulate Th17/Treg cell balance and inhibit immunoreaction by intervening in cytokines, transcription factors, and signal pathways. It enables us to comprehensively and deeply understand the mechanism of TCM intervening in Th17/Treg balance in RA; provides direction for clinical therapy of RA; and offers new thoughts for understanding the pathogenesis of RA.

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“…In our final paper on autoimmunity, also from 2022, Wang et al conducted a literature review of Scutellaria baicalensis georgi as a promising candidate for the treatment of autoimmune diseases. 98…”

Section: Fundingmentioning

confidence: 99%

Therapeutic Properties of Baicalin - A Literature Review

Cowley¹,

Deinert²

2022

Preprint

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This is a scientific literature review of much of the current research into the therapeutic benefits and mode of action of baicalin and its associated flavonoids.Of particular interest for the treatment of demyelinating diseases like MS or peripheral neuropathy, in 2022 Ai et al found that, using a neonatal mouse model, baicalin promotes myelin production and regeneration by activating the PPARγ signal pathway and also confirmed that BA is an effective natural product for the treatment of demyelinating diseases.Dosing, contraindications and administration in a clinical setting are then considered to conclude the review.

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Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

Cited by 14 publications

References 85 publications

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

The role, targets and mechanisms of traditional Chinese medicine in regulating the balance of T helper type 17/regulatory Tcells in rheumatoid arthritis

Therapeutic Properties of Baicalin - A Literature Review

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