This study examined networking’s impact on Nigerian communication enterprises, focusing on Globacom Nigeria Limited. Cross-border business has created challenges and opportunities for rising and emerging economies. Globacom Nigeria Limited has always looked beyond national borders for opportunities. Due to product demand, the company seeks new changes and faces overseas competition. In undeveloped countries, there are few quantitative studies on the relationship between networking and profitability. The study is survey-based. This training involved 24,400 employees (Globacom, 2017, as cited in Odiwo, 2018). Using Freund and Williams’ (1977, as cited in Godden, 2004) sample size determination (Cochran’s formula), 243 questionnaires and oral interviews were employed to collect data. A test-and-retest sampling strategy was employed to determine the association between variables. Networking increased the profitability of Nigerian communication enterprises (R = 0.99, P = 0.000). The learning proposes organizations employ networking to promote profitability and improve organizational effectiveness (Kapian & Nasayan, 2002; Etuk & Emenyi, 2022). Nigeria’s government should give innovative methods of doing things to improve commercial opportunities.