SDF-1 controls the muscle and blood vessel formation of the somite

Abduelmula, Aisha; Huang, Ruijin; Qin, Pu; Tamamura, Hirokazu; Morosan-Puopolo, Gabriela; Brand‐Saberi, Beate

doi:10.1387/ijdb.150132rh

Cited by 10 publications

(5 citation statements)

References 61 publications

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“…Recent studies reported that stromal cell-derived factor-1α (SDF1α) present in the secretome increases proliferation, viability, migration and homing of stem and progenitor cells; helps lymphoid tissue development and differentiation; and inhibits apoptosis of cells[ 4 , 12 ]. All these features are highly important for regeneration of damaged organs[ 13 ]. Furthermore, SDF1 and C-X-C-X-C chemokine receptor type 4 (CXCR-4) play a vital role in the high mobility group box 1 (HMGB1)-mediated inflammatory cell recruitment to the site of damaged tissue which is also vital for tissue repair and regeneration[ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Haque

Fareez

Fong

et al. 2020

WJSC

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In recent years, several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells. These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells. Interestingly, this notion has also led scientists to question the role of proteins in the secretome produced by cells, tissues or organisms under certain conditions or at a particular time of regenerative therapy. Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs. This could also facilitate the migration of immune, progenitor and stem cells within the body to the site of inflammation. Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived factor-1 (SDF1) that plays a vital role in tissue-specific migration of the cells needed for regeneration. Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration. Hence in this study, we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.

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Section: Introductionmentioning

confidence: 99%

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Haque

Fareez

Fong

et al. 2020

WJSC

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“…The CXCR4/SDF-1 axis is also necessary for the retrograde migration of the myogenic progenitors from the forelimb bud into trunk region 20 . Overexpression of Sdf-1 increases proliferation in the somite 38 . Furthermore, mice lacking Cxcr4 exhibit a considerable decrease in pectoral girdle musculature 20 .…”

Section: Discussionmentioning

confidence: 99%

“…A chemotactic effect of the CXCR4/SDF-1 axis has been described for trunk and cloacal muscle progenitor cell migration in chicken, where an SDF-1 gradient is established along their migratory routes 21,37 . Recent work from our lab established that SDF-1 stimulates the proliferation of angiogenic precursor cells of the somite and regulates myotome formation 38 . However, it still needs to be defined if the SDF-1 in the BA2 acts as a chemotactic signal for the migrating myogenic cells into the BA2.…”

Section: Discussionmentioning

confidence: 99%

Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles

Yahya

Böing

Qin

et al. 2020

Sci Rep

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The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial archderived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the second branchial arch, but not from the first, fail to form in Cxcr4 mutants at embryonic days E13.5 and E14.5. Cxcr4 is also required for the development of non-somitic neck muscles. in Cxcr4 mutants, non-somitic neck muscle development is severely perturbed. In vivo experiments in chicken by means of loss-of-function approach based on the application of beads loaded with the CXCR4 inhibitor AMD3100 into the cranial paraxial mesoderm resulted in decreased expression of Tbx1 in the BA2. Furthermore, disrupting this chemokine signal at a later stage by implanting these beads into the BA2 caused a reduction in MyoR, Myf5 and MyoD expression. In contrast, gain-of-function experiments based on the implantation of SDF-1 beads into BA2 resulted in an attraction of myogenic progenitor cells, which was reflected in an expansion of the expression domain of these myogenic markers towards the SDF-1 source. Thus, Cxcr4 is required for the formation of the BA2 derived muscles and non-somitic neck muscles.In vertebrates, trunk muscles originate from the somites, whereas most of the head muscles originate from the cranial paraxial mesoderm (CPM) 1,2 . Neck muscle progenitor cells are found in the transition zone between somite and CPM 3,4 . The CPM cells transiently migrate laterally into the region of the branchial arches and contributes to the muscles of the head 5,6 . These muscles can be divided into branchial, extra-ocular (EOM), axial and laryngoglossal muscles 2 . BAs are made of surface ectoderm, endoderm, myogenic mesodermal cells and neural crest cells (NCCs) 7 . The BA1 mesoderm contributes to formation of mastication muscles. The BA2 mesoderm gives rise to facial expression muscles 8 . Skeletal muscle progenitor cells in the more caudal BAs (3rd, 4th and 6th) are thought to contribute to neck muscles, for example the trapezius and sternocleidomastoideus, or its birds homologue the cucullaris muscle 3,4 . Clonal analysis reports that trapezius and sternocleidomastoid neck muscles are formed from non-somitic progenitor cells, whereas splenius muscle and laryngeal muscles have a dual origin (somitic and non-somitic) of the progenitor cells 3,4 . The genetic regulation of craniofacial myogenesis remains to be fully elucidated 5,8-10 .The signaling cascades that control pre-myogenic progenitor cell specification act distinctly in the head and trunk muscles 1,8 . Several pre-myogenic genes that are required to initiate myogenesis and maintain cells in an immature state in the trunk are known. Pax3, Pax7 and Lbx1 are crucial in specifying pre-myogenic progenitor cells in the dermomyotomes, the parts of the somites that gives rise to trunk and limb myoblasts 8,11 . The expression of Pax3 and Pax7 in somites is normally downregulated before activation of Myogenin...

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“…CXCR4/SDF-1 axis has previously been shown to play a role in the development of migrating muscle progenitor cells of the limb, tongue, pectoral girdle and cloaca (Odemis et al, 2005;Vasyutina et al, 2005;Yusuf et al, 2006;Rehimi et al, 2010;Masyuk et al, 2014). Furthermore, SDF-1 positively regulates the expression of irregular connective tissue markers during limb development and controls the formation of blood vessels in the somite (Abduelmula et al, 2016;Nassari et al, 2017). Recently, we reported that CXCR4/SDF-1 axis has a crucial role in facial and neck muscle development (Yahya et al, 2020b).…”

Section: Introductionmentioning

confidence: 95%

The CXCR4/SDF-1 Axis in the Development of Facial Expression and Non-somitic Neck Muscles

Yahya

Morosan-Puopolo

Brand‐Saberi

2020

Front. Cell Dev. Biol.

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Trunk and head muscles originate from distinct embryonic regions: while the trunk muscles derive from the paraxial mesoderm that becomes segmented into somites, the majority of head muscles develops from the unsegmented cranial paraxial mesoderm. Differences in the molecular control of trunk versus head and neck muscles have been discovered about 25 years ago; interestingly, differences in satellite cell subpopulations were also described more recently. Specifically, the satellite cells of the facial expression muscles share properties with heart muscle. In adult vertebrates, neck muscles span the transition zone between head and trunk. Mastication and facial expression muscles derive from the mesodermal progenitor cells that are located in the first and second branchial arches, respectively. The cucullaris muscle (non-somitic neck muscle) originates from the posterior-most branchial arches. Like other subclasses within the chemokines and chemokine receptors, CXCR4 and SDF-1 play essential roles in the migration of cells within a number of various tissues during development. CXCR4 as receptor together with its ligand SDF-1 have mainly been described to regulate the migration of the trunk muscle progenitor cells. This review first underlines our recent understanding of the development of the facial expression (second arch-derived) muscles, focusing on new insights into the migration event and how this embryonic process is different from the development of mastication (first arch-derived) muscles. Other muscles associated with the head, such as non-somitic neck muscles derived from muscle progenitor cells located in the posterior branchial arches, are also in the focus of this review. Implications on human muscle dystrophies affecting the muscles of face and neck are also discussed.

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SDF-1 controls the muscle and blood vessel formation of the somite

Abstract: Stromal-cell-derived factor-1 (SDF-1), the only ligand of the chemokine receptor CXCR4, is involved in skeletal muscle development. However, its role in the proliferation, differentiation and migration of somite cells is not well understood. Here, we investigated its function during somite

Cited by 10 publications

References 61 publications

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs

Cxcr4 and Sdf-1 are critically involved in the formation of facial and non-somitic neck muscles

The CXCR4/SDF-1 Axis in the Development of Facial Expression and Non-somitic Neck Muscles

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