Sdf‐1 (CXCL12) improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells

Abstract

Thus, positive impact of Sdf-1 on muscle regeneration is related to the mobilisation of endogenous cells, that is satellite cells and myoblasts, as well as non-muscle stem cells, expressing Cxcr4 and CD34.

Induction of CCAAT/Enhancer-Binding Protein β Expression With the Phosphodiesterase Inhibitor Isobutylmethylxanthine Improves Myoblast Engraftment Into Dystrophic Muscle

“…CXCR4 contributes to the migration of cells to dystrophic tissues that express high levels of SDF-1 and is required for myoblast migration [40,41,52]. CXCR4 is also a known target of C/EBPb in breast cancer cells [53].…”

“…CXCR4 is required for stromal cell-derived factor-1 (SDF-1) induced myoblast migration [40] and improves myogenic progenitor extravasation and engraftment into dystrophic muscle [41]. Because Cxcr4 expression was upregulated by IBMX in a C/EBPb-dependent manner, we examined whether IBMX improved migration of myoblasts in vitro.…”

The CXCR4/SDF1 Axis Improves Muscle Regeneration Through MMP-10 Activity

“…Accordingly, null mice for CXCR4 have a reduced number of satellite cells, leading to muscular deficiencies in the embryo [26]. However, the function of the CXCR4/SDF1 axis during adult myogenesis remains to be fully investigated [27][28][29][30], and its role in muscle repair has only recently begun to be characterized [31].…”

“…The CXCR4/SDF1 axis requires MMP-10 activity to induce muscle regeneration It was previously reported that various MMPs, such as MMP-2 or MMP-9, could interact with the CXCR4/SDF1 axis during the regulation of specific cellular processes [30,[42][43][44][45]. We recently described that the modulation of MMP-10 protein levels in injured muscle affects muscular regeneration [40].…”

CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche

“…This finding is consistent with previous reports in other tissue-committed stem cells. Notably, CXCR4 and CXCL12 knockout mice exhibit severe reduction of numbers of hematopoietic progenitors in the bone marrow (Sugiyama et al 2006), neural precursor cells that give rise to neurons, astrocytes and oligodendrocytes in the central nervous system (Ni et al 2004; Maysami et al 2006; Brzoska et al 2012), and PGCs in the gonads (Zou et al 1998; Ma et al 1998; Ara et al 2003). All of these phenotypes have been suggested to arise as a result of impaired migration or homing of cells to a supportive niche.…”