Seafood diets: Hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids

Elvevoll, Edel O.; Eilertsen, Karl‐Erik; Brox, Jan; Dragnes, Bjørn Tore; Falkenberg, Pål; Olsen, Jan Ole; Kirkhus, Bente; Lamglait, Amandine; Østerud, Bjarne

doi:10.1016/j.atherosclerosis.2007.12.021

Cited by 63 publications

(46 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, these studies used much higher daily doses of taurine than this present study; 10 to 170 times higher than the taurine present in the herring and beef diets. A clinical study showed that combined intake of the long-chain n-3 PUFA (EPA and DHA) and taurine had larger effects on total, LDL-and HDL-cholesterol concentrations than intake of long-chain n-3 PUFA alone (11). This proposed synergy effect between taurine and long-chain n-3 PUFA, present in herring but not in beef muscle, could be an explanation to the finding of maintained HDL-cholesterol and lower VLDL-cholesterol concentrations in the herring-fed mice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Gabrielsson

Wikström²,

Jakubowicz³

et al. 2011

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P= 0.007), and reduced epididymal adipocyte size (P= 0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and verylow-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P= 0.0012 and 0.004, VLDLcholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice.In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.

show abstract

Section: Discussionmentioning

confidence: 99%

“…However, epidemiological and large cohort studies do not normally differentiate between oily or lean fish species. That fact that fish, including lean fish species, also contain other bioactive compounds which can contribute to the health benefits of high fish intake has in recent years become of increasing interest (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Gabrielsson

Wikström²,

Jakubowicz³

et al. 2011

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…It is evident that individuals with high urinary excretion of taurine and high dietary intake of food high in taurine in general have fewer incidences of cardiovascular diseases compared to individuals with low dietary intake of taurine [33]. In addition, increased dietary intake of taurine either alone or in the combination with omega-3 fatty acids, has also been suggested to reduce MCP-1, an important risk factor of CVD [106]. No further randomised clinical trials on the effects of dietary supplementation of taurine on CVD disease markers has been reported.…”

Section: Effects Of Taurine On Atherosclerosis In Humansmentioning

confidence: 99%

“…However, the effect of taurine in relation to development of CVD has been documented through a human clinical trial. Results of a 7 week human intervention trial revealed that supplementation with 0.4 g taurine/day in combination with omega-3 fatty acids (1 g EPA+DHA/day) significantly improved the lipid profiles by reducing serum total and LDL cholesterol levels compared to supplementation with omega-3 fatty acids alone [106]. In another study the effects of oral supplementation with taurine (3 g/day) or placebo for 7 weeks was assessed in young obese healthy subjects [107].…”

Section: Effects Of Taurine On Cholesterol Levels In Humansmentioning

confidence: 99%

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Eilertsen¹,

Larsen²,

Mæhre³

et al. 2012

Lipoproteins - Role in Health and Diseases

Self Cite

View full text Add to dashboard Cite

“…Porphyra also contains various biologically active substances that are beneficial to human health (Noda, 1993). Seventeen free amino acids, including taurine, which controls blood cholesterol levels, are abundant in Porphyra (Elvevoll et al, 2008). In addition, Porphyra is a source of the red pigment R-phycoerythrin, which is used as a fluorescent tag for immunofluorescence studies (Kronick, 1986).…”

Section: Introductionmentioning

confidence: 99%

Selection of a L-Lysine-Overproducing Strain of the Red Seaweed Porphyra suborbiculata (Rhodophyta) through Mutation and Analog Enrichment

Luyen¹,

Chowdhury²,

Choi³

et al. 2012

Fisheries and aquatic sciences

View full text Add to dashboard Cite

An improved strain of the red seaweed Porphyra suborbiculata containing an increased amount of the essential amino acid llysine was obtained through mutation and analog enrichment. Mutagenesis using a 10% lethal dose of ultraviolet irradiation and an enrichment culture with the l-lysine analog aminoethyl-l-cysteine (AEC) was repeated to select the most productive strain using monospores of P. suborbiculata. The concentrations of AEC required to produce 50 and 100% inhibition of survival were 60 and 115 mM in the parent strain, and 72 and 135 mM in the selected AEC-resistant strain, respectively. The AEC-resistant strain, L130, produced 1.74-fold more lysine compared to its parent strain. Thus, mutagenesis with analog enrichment shows promise for selecting seaweed strains that can overproduce this essential amino acid.

show abstract

Seafood diets: Hypolipidemic and antiatherogenic effects of taurine and n-3 fatty acids

Cited by 63 publications

References 29 publications

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Anticholesterolemic and Antiatherogenic Effects of Taurine Supplementation is Model Dependent

Selection of a L-Lysine-Overproducing Strain of the Red Seaweed Porphyra suborbiculata (Rhodophyta) through Mutation and Analog Enrichment

Contact Info

Product

Resources

About