SealBio: A novel, non-obturation endodontic treatment based on concept of regeneration

Abstract

Introduction:“SealBio”, an innovative, non-surgical endodontic treatment protocol, based on “regenerative concept” has been developed to manage pulp and periapically involved teeth.Materials and Methods:Subsequent to Institute's ethical clearance, 18 patients presenting with signs and symptoms of pulp and periapical disease were included in the study. (11/M, 7/F; Mean age - 44.7 years; range 15-76 years). The protocol included a modified cleaning and shaping technique involving apical clearing and foramen widening, combined with inducing bleeding and clot formation in the apical region. Calcium-sulphate based cement was condensed with hand pluggers into the canal orifices. An appropriate permanent restoration was given. The patients were followed-up clinically and radiographically at regular interval of 6 months. Six teeth in 3 patients were also evaluated pre and post treatment CBCT at 6-months.Results:The novel treatment protocol was found to be favourable in resolving periapical infection, both clinically and radiographically.Conclusions:This innovative endodontic treatment protocol highlights and reiterates the importance of cleaning and shaping and puts forth the possible role of stem cells and growth factors in healing after non-surgical endodontic therapy.

Management of Teeth with Persistent Apical Periodontitis after Root Canal Treatment Using Regenerative Endodontic Therapy

“…In conclusion, if mature teeth with necrotic pulp and apical periodontitis can be treated using RET (12)(13)(14), teeth with persistent apical periodontitis after root canal therapy may also be managed with RET after careful root canal infection control (20). The treatment objectives and goals of nonsurgical root canal therapy and RET are the sameelimination of clinical signs/symptoms and healing of apical periodontitis.…”

“…Recently, mature permanent teeth with necrotic pulps and apical periodontitis have been successfully treated using RET (12)(13)(14). The treatment eliminates clinical signs/symptoms and resolves apical periodontitis.…”

“…Based on the results of mature teeth with infected necrotic pulps and apical periodontitis successfully treated using RET (12)(13)(14), it was believed that teeth with persistent apical periodontitis after root canal therapy might also be able to be managed using RET because the objectives and goals of primary and secondary root canal treatment are the same. The purpose of this case report was to describe the potential of using RET to treat 2 teeth with persistent apical periodontitis after root canal therapy.…”

Conservative management of dens evaginatus and attached supernumerary tooth/odontome in mandibular premolar with dual radiolucencies

“…Recently, Shah and Logani introduced an innovative, nonsurgical regenerative endodontic treatment protocol “SealBio” to manage mature, nonvital permanent teeth with periapical lesions. [ 9 ] It helps in achieving a definite cemental/fibrous barrier at the root apex. [ 9 ] This paper describes the management of DE and an attached supernumerary tooth/an odontome associated with two distinct radiolucencies in a mandibular premolar with “SealBio” technique and discusses the various hypotheses on the pathogenesis of unusual malformation and associated pericervical cyst-like radiolucency in the involved tooth.…”

Comment on: SealBio: A novel, non-obturation endodontic treatment based on concept of regeneration

“…We read with great interest the article by Shah and Logani[1] regarding the formation of a biological seal after revascularization procedures. Unfortunately, the formation of so-called “biological seal” has not been demonstrated in the entire manuscript.…”