ObjectivesThe aim of the present study was to compare the sealing efficacy of root fillings made by a single-cone technique with three different sealers and a cold lateral compaction technique with an epoxy sealer.Materials and methodsEighty extracted single-rooted human teeth were assigned to four experimental groups: group 1, single-cone and epoxy sealer; group 2, single-cone and calcium silicate-based sealer; group 3, single-cone and methacrylate resin-based sealer; and group 4, cold lateral compaction and epoxy sealer. Twenty extra teeth served as negative and positive controls. After preparation of a coronal post space, the sealing efficacy of the root fillings was assessed on a fluid transport setup. The results were analyzed using Kruskal-Wallis and Mann-Whitney U test.ResultsNo fluid transport was detected for the negative controls whereas all the positive controls showed rapid fluid transport. No significant difference was detected between groups 1, 3, and 4 whereas group 2 demonstrated significantly more fluid transport than all the other experimental groups.ConclusionsRoot fillings made by a single-cone technique with the epoxy or methacrylate-based sealers were as effective after post space preparation as those made by a cold lateral technique with the epoxy sealer in sealing the root canal.Clinical RelevanceSpecific root canal sealers in combination with single-cone technique represent a noteworthy alternative to the use of cold lateral compaction technique when a post space is required. The use of effective endodontic procedures with simplified technical implementation may positively affect endodontic outcome.