Seamless route of self-assembly and 3D printing to fabricate hierarchical mesoporous bioactive glass scaffold for customized bone regeneration with enhanced efficacy

Wang, Zeying; Lin, Dan; Wang, Minjiao; Mao, Runyi; Zhao, Hanjiang; Huang, Xingtai; Shen, Shui-Long

doi:10.1016/j.cej.2022.137270

Cited by 14 publications

(7 citation statements)

References 44 publications

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“…To this aim, they combined sol-gel technology with polymer-photo curing. In this case, the structure-directing agent (F127) was modified to perform both self-assembly and UV curing of the MBG sol precursor during 3DP [111]. The resulting scaffolds displayed enhanced interconnectivity, faster in vitro biodegradation and performance and bone regenerative efficacy in a critical-size rat cranial defect model.…”

Section: Mesoporous Bioactive Glasses In the Context Of Bone Tissue R...mentioning

confidence: 99%

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

et al. 2022

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Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for local drug delivery. Since their discovery at the beginning of the 21st century, pioneering research efforts focused on the design and fabrication of MBGs with optimal compositional, textural and structural properties to elicit superior bioactive behavior. The current trends conceive MBGs as multitherapy systems for the treatment of bone-related pathologies, emphasizing the need of fine-tuning surface functionalization. Herein, we focus on the recent developments in MBGs for biomedical applications. First, the role of MBGs in the design and fabrication of three-dimensional scaffolds that fulfil the highly demanding requirements for bone tissue engineering is outlined. The different approaches for developing multifunctional MBGs are overviewed, including the incorporation of therapeutic ions in the glass composition and the surface functionalization with zwitterionic moieties to prevent bacterial adhesion. The bourgeoning scientific literature on MBGs as local delivery systems of diverse therapeutic cargoes (osteogenic/antiosteoporotic, angiogenic, antibacterial, anti-inflammatory and antitumor agents) is addressed. Finally, the current challenges and future directions for the clinical translation of MBGs are discussed.

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Section: Mesoporous Bioactive Glasses In the Context Of Bone Tissue R...mentioning

confidence: 99%

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

et al. 2022

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“…The organic–inorganic composites such as bioactive glasses, wollastonite, calcium silicate (CS), and β-tricalcium phosphate are particularly capable of mimicking the chemical composition of bone. Among them, CS is a promising inorganic, vitreous structure, and synthetic material for producing scaffolds for bone regeneration, accounting for its appealing properties such as biocompatibility, osteoinductivity, osteoconductivity, and appreciable mechanical properties . The success of a bioactive material (BM) can be credited to its ability to bind with bone tissue by forming a hydroxyapatite (HAp) layer and stimulating osteogenesis by releasing biologically active ions .…”

Section: Introductionmentioning

confidence: 99%

“…Among them, CS is a promising inorganic, vitreous structure, and synthetic material for producing scaffolds for bone regeneration, accounting for its appealing properties such as biocompatibility, osteoinductivity, osteoconductivity, and appreciable mechanical properties. 3 The success of a bioactive material (BM) can be credited to its ability to bind with bone tissue by forming a hydroxyapatite (HAp) layer and stimulating osteogenesis by releasing biologically active ions. 4 In addition to this, BM promotes angiogenesis during the formation of new tissue.…”

Section: ■ Introductionmentioning

confidence: 99%

Sustainable Development of a Bioactive Material from Recycled Rice Husk and Eggshell for Bone Regeneration Application

Shendage,

Ingole,

Rasal

et al. 2024

ACS Sustainable Chem. Eng.

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Developing an efficient, economical, green, and sustainable approach for the synthesis of a bioactive material (BM) for bone tissue engineering is a need of the moment because BM possesses appealing characteristics (excellent binding efficiency, bioactivity, osteogenesis, angiogenesis, antimicrobial activity, and controlled degradation rate). The present work demonstrates the synthesis of 70S30C calcium silicate (CS) using recycled rice husk (silica source) and eggshell (calcium source) via a simple precipitation method. The BET analysis confirmed its mesoporous nature (surface area of 74.65 m 2 /g). Furthermore, the bioactivity study using simulated body fluids revealed the growth of hydroxyapatite (HAp) on the synthesized material (XRD, FTIR, and SEM-EDS analysis), which plays a crucial role during bone regeneration. The 70S30C CS exhibited excellent mechanical properties, biocompatibility (in vitro study using MG-63 cells), antibacterial activity (in vitro and in vivo against E. coli and Staphylococcus aureus), and angiogenesis (CAM model). The Cirrhinus mrigala fish used for the in vivo study revealed its nontoxicity and showed matrix proteoglycans, vascularization, collagen I protein, and bone healing at the fracture site. The current study broadens the biomedical application of rice husk and eggshell-derived BM prepared completely from recycled waste (eco-friendly approach), offering bioactivity, bacterial inhibition, angiogenesis, and bone healing capability.

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“…Additive manufacturing, often referred to as three-dimensional (3D) printing, enables efficient product development with different designs, enhancing the manufacturing capacity for complex structures and facilitating the on-demand production of 3D objects. , As 3D printing exhibits diverse applications in catalysis, tissue engineering, , and soft robotics, the development of 3D-printed materials continues to attract considerable attention. 3D printing is categorized into various technologies, in which the material and performance requirements of the final product often determine the specific type of printing.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Photocurable Resin with Synergistic Hydrogen Bonding Based on Deep Eutectic Solvent

Kankala

et al. 2023

ACS Appl. Polym. Mater.

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Vat polymerization, one of the 3D printing technologies, has been widely applied owing to its advantageous properties, such as high accuracy and surface quality. However, the applicability of this technology is limited to end-use product manufacturing, requiring advancements due to a gradual increase in the performance requirements and functional demands of the products. In this study, deep eutectic solvent-based photocurable resins (PCRs) with synergistic hydrogen bonding are synthesized using a facile and ecofriendly procedure to tune monomer proportions. The as-prepared PCRs, with ultralow viscosity and ultrahigh curing rate, are compatible with commercial liquid-crystal display printers. The 3D-printed parts with high optical transparency, stiffness, and thermal resistance exhibit humidity-dependent electrical conductivity and mechanical properties. In addition, the 3D-printed objects demonstrate self-healing features due to the synergistic effect of high-density hydrogen bonding in the microphase-separated polymer matrix. Moreover, different categories of structural assembly, from 2D to 3D and small to large, are demonstrated, and their solubility ensued in recycling and remolding. The synthesized PCRs are suitable for fabricating sacrificial molds, enabling the on-demand fabrication of precise multifunctional structures with various materials, which are otherwise incompatible with UV-based 3D printing, facilitating 3D printing by overcoming its material-selection limitations.

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Seamless route of self-assembly and 3D printing to fabricate hierarchical mesoporous bioactive glass scaffold for customized bone regeneration with enhanced efficacy

Cited by 14 publications

References 44 publications

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

Sustainable Development of a Bioactive Material from Recycled Rice Husk and Eggshell for Bone Regeneration Application

3D-Printed Photocurable Resin with Synergistic Hydrogen Bonding Based on Deep Eutectic Solvent

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