Search for an adenovirus etiology of human oral and pharyngeal tumors

Rangan, S. R. S.; Mukherjee, Ayan; Bang, Frederik B.

doi:10.1002/ijc.2910030615

Cited by 10 publications

(1 citation statement)

References 10 publications

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“…The reason for the late development of the S antibody is not understood. However, little is known about the development and persistence of antibodies to virus-induced non-structural antigens in human beings, although the presence of antibody to T antigens of adenoviruses in human sera has been reported (Lewis et a/., 1967;Malmgren et al, 1968;Rangan et al, 1968). Several possibilities might be considered to account for the present observation.…”

Section: Discussionmentioning

confidence: 66%

Antibodies to eb virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients

Vonka

Vlcková

Závadová

et al. 1972

Intl Journal of Cancer

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Sera from inlfectious mononucleosis patients aged 2 to 35 years and from normal subjects aged I I to 35 years were examinedfor the presence of antibody to the EB virus capsid antigen ( V C A ) Extracts of Burkitt lymphoma and other lymphoblastoid cell lines contain a soluble (S)antigen demonstrated by complement-fixation (CF) test (Armstrong P I ul., 1966;Vonka et al., 1969;1970a; 1970b;Pope et al., 1969;Gerber and Diehl, 1970). This antigen was found in both EB-virus-positive and -negative cell lines and was immunologically distinct from the viral capsid antigen (VCA) as detected by immunofluorescence (IF) or CF test. The S antibody, although present in many human sera, was never found in sera which were free of antibody to VCA. This indicates that EB virus infection is the pre-requisite for the S antibody development. On the basis of these observations the suggestion was made that the S antigen is an EB virus coded non-structural antigen.When studying the age distribution of VCA and S antibodies in human sera we found that 50 to 70% of subjects over 1 year of age, whose sera were VCA-positive, also possessed the S antibody. The antibody pattern was markedly different in children aged 6 to 12 months: only one out of 15 VCA-positive subjects in one group (Vonka et al., 1970a) and none of 30 VCApositive in the other group (Vonka and BenyeshMelnick, 1970) possessed the S antibody. The absence of S antibody in VCA-positive subjects aged 6 to 12 months, i.e. subjects most probably infected with EB virus only recently,

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Section: Discussionmentioning

confidence: 66%

Antibodies to eb virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients

Vonka

Vlcková

Závadová

et al. 1972

Intl Journal of Cancer

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A new human cell line (FaDu) from a hypopharyngeal carcinoma

Rangan

1972

Cancer

179

114

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A human epithelial cell line, FaDu, from a squamous cell carcinoma of the hypopharynx has been isolated and established from a patient from Calcutta, India. The cell line has a population doubling time of approximately 50 hours. Ultrastructural observation reveals the presence of bundles of tonofilaments in the cells and desmosomal regions distributed at the boundaries of adjacent cells. The cell line is susceptible to infection by some RNA‐ and DNA‐containing viruses.

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Tumorgenicity of Herpesvirus hominis type 2‐transformed cells (line 333‐8‐9) in adult hamsters

Shortland

Mousawy

Rees

et al. 1979

The Journal of Pathology

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Inoculation of adult hamsters with greater than 1.5 X 10(2) Herpesvirus type 2 (HSV-2) transformed hamster embryo fibroblasts induced rapidly growing tumours at the site of inoculation, in more than 50 per cent of animals. The tumours were examined by light and electron microscopy, and were histologically anaplastic fibrosarcomas. Lung metastases were frequently found in tumour-bearing animals; these were usually only seen microscopically, and were cytologically similar to the primary tumours. The nature of tumour development showed similarities with naturally occurring tumours of man, and HSV-2 tumour is probably a better model of human cancer than other virus-induced tumours studied in the past.

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Search for an adenovirus etiology of human oral and pharyngeal tumors

Cited by 10 publications

References 10 publications

Antibodies to eb virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients

Antibodies to eb virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients

A new human cell line (FaDu) from a hypopharyngeal carcinoma

Tumorgenicity of Herpesvirus hominis type 2‐transformed cells (line 333‐8‐9) in adult hamsters

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