Search for antibacterial and antifungal agents from selected Indian medicinal plants

Kumar, Vipin; Chauhan, Neelam; Padh, Harish; Rajani, M.

doi:10.1016/j.jep.2006.03.013

Cited by 352 publications

(182 citation statements)

References 7 publications

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“…3 A. webbiana leaves has been reported as antibacterial and antifungal, mast cell stabilizing, anxiolytic, anti-tumor, anti-inflammatory, anti-tussive, female antifertility, febrifuge, anti-spasmodic properties, Central nervous system (CNS) depressant actions and are effective against hyperglycemia, conception, rheumatism and high temperature. 2,[4][5][6][7][8] In phytochemical screening certain chemical constituents, mainly monoterpenes (from essential oil), flavonoids, biflavonoid glycosides, phytosterols, amino acids, saponins, tannins, alkaloids, lipids, triterpenoids, steroids and glycosides were found and a new alkaloid namely 1-(4'-methoxyphenyl)-aziridine, a nitrogenous compound and a new biflavonoid, Abiesin have been isolated. [9][10][11][12][13] The present study focuses on the isolation and assess effect on liver and kidney of flavonoid from ethyl acetate extract of A. webbiana.…”

Section: Introductionmentioning

confidence: 99%

Isolation of flavonoid from Abies webbiana leaves and its activity

Yadav¹,

M²,

Ghosh³

et al. 2016

Phcogj

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Background: Abies webbiana commonly known as Talispatra in Bengali and Hindi, Talispatram in Sanskrit and Indian Silver Fir in English. This is a large, tall, evergreen tree occurring in the Himalayan region from Kashmir to Assam in India. It comes under the Family: Pinaceae. The present study was designed for isolation of flavonoid from ethyl acetate extract of A. webbiana leaves and assessed their toxic effect on liver and kidney. Materials and Methods: The isolation of flavonoid using different chroma tographic methods (thin layer and column chromatography). The isolated flavonoid was identified; Structures and chemical bonds were analyzed by using MP, FTIR, 1 H NMR and MS spectral analysis. Effect of flavonoid on liver and kidney was assessed by inducing (0.1 ml/kg) CCl 4 (i.p.) and (6 mg/kg) Cisplatin (i.p.) respectively measured by biochemical marker of liver and kidney. Results and Discussion: It was identified that isolated compound

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Section: Introductionmentioning

confidence: 99%

Isolation of flavonoid from Abies webbiana leaves and its activity

Yadav¹,

M²,

Ghosh³

et al. 2016

Phcogj

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“…20) Earlier communications have documented anthelmintic, antibacterial and antiallergic activities of MPM and justified, especially, its ethnomedical use against intestinal worms. [21][22][23] But, so far there is no report on its anti-H. pylori activity and so for its constituents. Among the isolated compounds, rottlerin demonstrated the most potent activity with MBC value range from 3.12-6.25 mg/l in all of the strains evaluated.…”

Section: Discussionmentioning

confidence: 99%

Potent Bactericidal Constituents from Mallotus philippinensis against Clarithromycin and Metronidazole Resistant Strains of Japanese and Pakistani Helicobacter pylori

Zaidi

Yoshida

Butt

et al. 2009

Biological & Pharmaceutical Bulletin

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In the quest for potent anti-Helicobacter pylori agents, we found 70% EtOH extract of Mallotus philippinensis (LAM.) MUELL. (MPM) with strong bactericidal activity at the concentration of 15.6-31.2 mg/l against eight H. pylori strains. Further fractionation and purification of 70% EtOH extract of MPM led to the isolation of 5 compounds, namely 5,7-dihydroxy-8-methyl-6-prenylflavanone (1), 3 -prenylrubranine (2), red compound (3), isorottlerin (4), and rottlerin (5) which were elucidated on the basis of nuclear magnetic resonance and mass spectroscopy. Among the isolated compounds, rottlerin exhibited most potent bactericidal activity with minimum bactericidal concentration (MBC) value of 3.12-6.25 mg/l against several clinical H. pylori isolates including Japanese and Pakistani strains, nine clarithromycin resistant (CR), and seven metronidazole resistant (MR) strains. Minimum inhibitory concentration (MIC) values of CR (8-Ͼ Ͼ256 mg/l) and MR (Ͼ Ͼ256 mg/l) strains were analyzed by E test. Moreover, the clarithromycin resistant strains were evaluated for A2143G and A2144G point mutations of 23s rRNA gene to correlate the MBC values with mutation type. Our results revealed the potent in vitro anti-H. pylori activity of MPM and rottlerin, specially against CR and MR strains, which could be gainfully utilized for the development of novel antimicrobials to prevent H. pylori related disorders.

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“…It was found to contain flavonoids, phenolic compounds and pro anthocyanidins (Luximon et al, 2002). C. fistula extracts have been reported for various pharmacological activities including antiinflammatory (Rajeswari et al, 2006), antioxidant (Irshad et al, 2012), antimicrobial (Irshad et al, 2013), wound healing properties (Kumar et al, 2006) and anticancer activity (Irshad et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Phytochemicals in the Bark Extracts of Medicinally Important Plant Cassia fistula, Linn.

Chinna¹

2017

Int.J.Curr.Microbiol.App.Sci

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Search for antibacterial and antifungal agents from selected Indian medicinal plants

Cited by 352 publications

References 7 publications

Isolation of flavonoid from Abies webbiana leaves and its activity

Isolation of flavonoid from Abies webbiana leaves and its activity

Potent Bactericidal Constituents from Mallotus philippinensis against Clarithromycin and Metronidazole Resistant Strains of Japanese and Pakistani Helicobacter pylori

Quantitative Analysis of Phytochemicals in the Bark Extracts of Medicinally Important Plant Cassia fistula, Linn.

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