Search for blood or water is influenced by Borrelia burgdorferi in Ixodes ricinus

Herrmann, Coralie; Gern, Lise

doi:10.1186/s13071-014-0526-2

Cited by 61 publications

(57 citation statements)

References 70 publications

(114 reference statements)

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“…Summer camps take place in July or August. While hazard may be reduced at this time as it falls between the two peaks of activity (spring and autumn) (Herrmann and Gern, 2015), exposure for scouts is non-negligible when outdoor living is practiced for a full fortnight. Also, the spring and autumn peaks are not always observed and abundance can be fairly stable across seasons (Randolph et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Scouts, forests, and ticks: Impact of landscapes on human-tick contacts

Keukeleire

Vanwambeke

Somassè

et al. 2015

Ticks and Tick-borne Diseases

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Section: Introductionmentioning

confidence: 99%

Scouts, forests, and ticks: Impact of landscapes on human-tick contacts

Keukeleire

Vanwambeke

Somassè

et al. 2015

Ticks and Tick-borne Diseases

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“…The mechanism by which anti-tick immunity reduces tick fitness is that it impairs tick blood feeding and therefore reduces the quality and quantity of the blood meal (21). With respect to body size, previous studies on I. ricinus have shown that larger nymphs have higher fat reserves (46) and that such nymphs can quest for longer periods of time, which increases their chances of finding a host in the field (9, 47, 48). Body size also influences female fecundity, with larger female ticks laying larger clutches of eggs (49).…”

Section: Discussionmentioning

confidence: 99%

“…Specificity is shown by the fact that many vector-borne pathogens are only effectively acquired and transmitted by one or a few closely related vector species (4-6). Examples of adaptive complexity in pathogens include increasing the vector’s production of immunosuppressive saliva molecules to enhance their own transmission (7), protecting the vector against changes in the environment (8, 9), and manipulating the odor profile of the vertebrate host to increase host-vector encounter rates and pathogen transmission (10-12). Thus, whenever it suits their interests, we expect vector-borne pathogens to enhance the fitness of their arthropod vectors.…”

Section: Introductionmentioning

confidence: 99%

Borrelia afzeliidoes not suppress the development of anti-tick immunity in bank voles

Gomez-Chamorro

Herrera

et al. 2020

Preprint

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Vector-borne pathogens manipulate their vertebrate hosts to enhance their transmission to arthropod vectors. The ability of vertebrate hosts to develop acquired immunity against arthropod vectors represents an existential threat for both the vector and the pathogen. The purpose of the study was to test whether the tick-borne spirochete bacterium Borrelia afzelii could suppress the development of acquired immunity to its tick vector Ixodes ricinus in the bank vole Myodes glareolus, which is an important host for both the tick and the pathogen. We created a group of B. afzelii-infected bank voles and an uninfected control group by exposing lab-reared animals to infected or uninfected ticks. At 1, 2, and 3 months post-infection, all bank voles were infested with larval I. ricinus ticks. The bank voles developed a strong antibody response against tick salivary gland extract proteins. This anti-tick immunity had negative effects on tick fitness traits including engorged larval weight, unfed nymphal weight, larva-to-nymph molting time and larva-to-nymph molting success. Infection with B. afzelii did not suppress the development of acquired immunity against I. ricinus ticks. The development of anti-tick immunity was strongly correlated with a dramatic temporal decline in both the bacterial abundance in the host ear tissues and the host-tick transmission success of B. afzelii. Our study suggests that the development of anti-tick immunity in bank voles has important consequences for the density of infected ticks and the risk of Lyme borreliosis.ImportanceMany pathogens enhance their persistence and transmission by suppressing the immune system of their host. We used an experimental infection approach to test whether the Lyme disease pathogen, Borrelia afzelii, could suppress the development of acquired immunity against its tick vector (Ixodes ricinus) in the bank vole (Myodes glareolus), but found no evidence for this phenomenon. Uninfected and B. afzelii-infected bank voles both developed a strong IgG antibody response against tick salivary gland extract following repeated infestations with I. ricinus ticks. The development of anti-tick immunity was negatively correlated with the abundance of B. afzelii in ear tissue biopsies and with host-to-tick transmission to I. ricinus ticks. Our study suggests that anti-tick immunity in the bank vole reduces the prevalence of this important tick-borne pathogen.

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“…Bu kenelerin yayılım alanlarının iklim değişikliğinin etkisiyle oluşan daha sıcak ve kuru hava ile artacağından endişe edilmektedir. ABD'de vektör olan kene türlerinden Ixodes persulcatus aynı zamanda babesiyoz ve insan anaplazmoz etkenlerini taşırken, Avrupa ve Asya'da hakim olan vektör kene türlerinden Ixodes ricinus ve Ixodes persulcatus LH'nın yanı sıra kene kaynaklı ensefalit etkenlerini taşıyabilmektedir [8] .…”

Section: Epidemiyolojiunclassified

“…ABD'de 2014 yılında 25,359 olgu doğrulanmış olarak, 8,102 olgu da olası olgu olarak bildirilmiştir [9] . Avrupa'da en fazla olgu saptanan bölge ise iç Avrupa kıtası ve İskandinavya'dır [1,8] .…”

Section: Epidemiyolojiunclassified

Lyme Disease

Hatipoğlu¹,

Turhan²

2016

mjima

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Lyme borelyozu olarak da bilinen ve Ixodes türü keneler ile taşınan Lyme hastalığı (LH) kuzey yarımkürenin en yaygın zoonotik hastalığıdır. Türkiye'de hastalık prevalansı tam olarak bilinmemekle birlikte, seroepidemiyolojik çalışmalarda prevalansın %2-44 arasında değiştiği bildirilmiştir. Olgu sunumları hastalığın ülkemizde de endemisite gösterdiğini düşündürmektedir. Ixodes ricinus türü kenelerin Trakya Bölgesi'nde Borrelia burgdorferi (B. burgdorferi) sensu lato grubundaki türlerden B. burgdorferi sensu stricto, Borrelia garinii, Borrelia afzelii, Borrelia lusitania ve Borrelia valaisiana'yı taşıdığı saptanmıştır. Tedavisiz kalan borelyozlu bir hastada üç evre görülebilir. İlk evrede eritema migrans (EM) ve grip benzeri hastalık görülebilmektedir. İkinci evre ise etkenin alınmasından 3-10 hafta sonra, eklem, sinir sistemi, göz, kalp tutulumu ve çok sayıda EM lezyonlarının gelişebildiği evredir. Son evre ise aylar yıllar sonra, EM lezyonlarının olmadığı, %11 civarında hastada görülen, eklem ve nörolojik tutulumların öne çıktığı evredir. Tedavide tutulan organ ve hastalık ciddiyetine göre antibiyoterapi veriliş şekli ve süresi değişebilir. Antibiyoterapi kadar antienflamatuvar tedavi de önemlidir. EM'nin görülmediği farklı klinik seyirler tanısal güçlüğe ve hastalığın tedavisiz kalmasına neden olabilmektedir. Kene tutunma öyküsü olmasa da hastalığın ayırıcı tanıda düşünülmesi ve erken dönemde tanısının konularak antibiyotik tedavisinin başlanması önemlidir. Lyme hastalığının erken tanı, tedavi ve kontrolü için, hastalığın endemik olduğu bölgelerin belirlenmesine, toplum ve hekimler arasında duyarlılığı artırıcı faaliyetlerin uygulanmasına ihtiyaç vardır.

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Search for blood or water is influenced by Borrelia burgdorferi in Ixodes ricinus

Cited by 61 publications

References 70 publications

Scouts, forests, and ticks: Impact of landscapes on human-tick contacts

Scouts, forests, and ticks: Impact of landscapes on human-tick contacts

Borrelia afzeliidoes not suppress the development of anti-tick immunity in bank voles

Lyme Disease

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