Search for Large Extra Dimensions in Dielectron and Diphoton Production

Abbott, B.; Abolins, M.; Abramov, V.; Acharya, B. S.; Adams, T.; Adams, M. R.; Alves, G. A.; Amos, N.; Anderson, E. W.; Baarmand, M. M.; Babintsev, V.; Babukhadia, L.; Baden, A.; Baldin, B.; Balm, P. W.; Banerjee, S.; Bantly, J.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bean, A.; Begel, M.; Belyaev, A.; Beri, S. B.; Bernardi, G.; Bertram, I.; Besson, A.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Bhattacharjee, M.; Blazey, G.; Blessing, S.; Boehnlein, A.; Bojko, N. I.; Borcherding, F.; Brandt, A.; Breedon, R.; Briskin, G.; Brock, R.; Brooijmans, G.; Bross, A.; Buchholz, D.; Buehler, M.; Buescher, V.; Буртовой, В. С.; Butler, J. M.; Canelli, F.; Carvalho, W.; Casey, D.; Casilum, Z.; Castilla‐Valdez, H.; Chakraborty, D.; Chan, K. M.; Chekulaev, S. V.; Cho, D. K.; Choi, S.; Chopra, S.; Christenson, J. H.; Chung, M.; Claes, D. R.; Clark, A. R.; Cochran, J.; Coney, L.; Connolly, B.; Cooper, W. E.; Coppage, D.; Cummings, M. A.C.; Ćutts, D.; Dahl, O. I.; Davis, G. A.; Davis, K.; De, K.; Signore, K. Del; Demarteau, M.; Démina, R.; Demine, P.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; Loreto, G. Di; Doulas, S.; Draper, P.; Ducros, Y.; Dudko, L.; Duensing, S.; Dugad, S.; Dyshkant, A.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Engelmann, R.; Eno, S.; Eppley, G.; Ermolov, P.; Eroshin, O. V.; Estrada, J.; Evans, H.; Евдокимов, В. Н.; Fahland, T.; Fehér, S.; Fein, D.; Ferbel, T.; Fisk, H. E.; Fisyak, Y.; Flattum, E.; Fleuret, F.; Fortner, M.; Frame, K. C.; Fuess, S.; Gallas, E. J.; Galyaev, A. N.; Gartung, P.; Gavrilov, V.; Genik, R. J.; Genser, K.; Gerber, C. E.; Gershtein, Y.; Gibbard, B.; Gilmartin, R.; Ginther, G.; Gómez, B.; Gómez, G.; Goncharov, P. I.; Solís, J. L. González; Gordon, H. A.; Goss, L. T.; Gounder, K.; Goussiou, A. G.; Graf, N.; Graham, Gerard J.; Grannis, P. D.; Green, J. A.; Greenlee, H.; Grinstein, S.; Groer, L.; Grudberg, P.; Grünendahl, S.; Gupta, A.; Gurzhiev, S. N.; Gutiérrez, G.; Gutiérrez, P.; Hadley, N. J.; Haggerty, H.; Hagopian, S.; Hagopian, V.; Hahn, K. S.; Hall, R. E.; Hanlet, P.; Hansen, S.; Hauptman, J. M.; Hays, C. P.; Hébert, C.; Hedin, D.; Heinson, A. P.; Heintz, U.; Heuring, T.; Hirosky, R.; Hobbs, J.; Hoeneisen, B.; Hoftun, J. S.; Hou, S.; Huang, Y.; Ito, A. S.; Jerger, S. A.; Jesik, R.; Johns, K.; Johnson, M.; Jonckheere, A.; Jones, M.; Jöstlein, H.; Rozas, A. Juste; Kahn, S.; Kajfasz, E.; Karmanov, D.; Karmgard, Daniel John; Kehoe, R.; Kim, S. K.; Klima, B.; Klopfenstein, C.; Knuteson, B.; Ko, W.; Kohli, J. M.; Kostritskiy, A. V.; Kotcher, J.; Kotwal, A.; Kozelov, A. V.; Kozlovsky, E. A.; Krane, J.; Krishnaswamy, M. R.; Krzywdziński, S.; Kubantsev, M.; Kuleshov, S.; Kulik, Y.; Kunori, S.; Кузнецов, В. Е.; Landsberg, G.; Leflat, A.; Lehner, F.; Li, J.; Li, Q. Z.; Lima, J. G.R.; Lincoln, D.; Linn, S.; Linnemann, J.; Lipton, R.; Lucotte, A.; Lueking, L.; Lundstedt, C.; Maciel, A. K.A.; Madaras, R. J.; Manankov, V.; Mao, H. S.; Marshall, T.; Martin, M.; Martin, R.; Mauritz, K. M.; May, B.; Mayorov, A. A.; McCarthy, R. L.; McDonald, John; McMahon, T. R.; Melanson, H. L.; Meng, X. C.; Merkin, M.; Merritt, K. W.; Miao, C.; Miettinen, H.; Mihalcea, D.; Mincer, A. I.; Mishra, C. S.; Mokhov, N.; Mondal, N. K.; Montgomery, H. E.; Moore, R. W.; Mostafa, M.; Motta, H. da; Nagy, E.; Nang, F.; Narain, M.; Narasimham, V. S.; Neal, H. A.; Negret, J. P.; Negroni, S.; Norman, D.; Oesch, L.; Oguri, V.; Olivier, B.; Oshima, N.; Padley, P.; Lu, Pan; Para, A.; Parashar, N.; Partridge, R.; Parua, N.; Paterno, M.; Patwa, A.; Pawlik, B.; Perkins, J.; Peters, Michael; Peters, O.; Piegaia, R.; Piekarz, H.; Pope, B. G.; Popkov, E.; Prosper, H.; Protopopescu, S.; Qian, J.; Quintas, P. Z.; Raja, R.; Rajagopalan, S.; Ramberg, E.; Rapidis, P. A.; Reay, N. W.; Reucroft, S.; Rha, J.; Rijssenbeek, M.; Rockwell, T.; Roco, M.; Rubinov, P.; Ruchti, R.; Rutherfoord, J. P.; Santoro, A.; Sawyer, L.; Schamberger, R. D.; Schellman, H.; Schwartzman, A.; Sculli, J.; Sen, N.; Shabalina, E.; Shankar, H. C.; Shivpuri, R. K.; Shpakov, D.; Shupe, M. A.; Sidwell, R. A.; Šimák, V.; Singh, H.; Singh, J. B.; Sirotenko, V.; Slattery, P.; Smith, E.; Smith, R. P.; Snihur, R.; Snow, G. R.; Snow, J.; Snyder, S.; Solomon, J.; Sorı́n, V.; Sosebee, M.; Sotnikova, N.; Soustružnı́k, K.; Souza, M. H.G.; Stanton, N. R.; Steinbrück, G.; Stephens, R. W.; Stevenson, M. L.; Stichelbaut, F.; Stoker, D. P.; Stolin, V.; Stoyanova, D. A.; Strauss, M.; Streets, K.; Strovink, M.; Stutte, L.; Sznajder, A.; Taylor, W.; Tentindo-Repond, S.; Thompson, J.; Toback, D.; Tripathi, S. M.; Trippe, T. G.; Turcot, A. S.; Tuts, P. M.; Gemmeren, P. van; Vaniev, V.; Kooten, R. Van; Varelas, N.; Volkov, A.; Vorobiev, A. P.; Wahl, H. D.; Wang, H.; Wang, Z. M.; Warchol, J.; Watts, G.; Wayne, M.; Weerts, H.; White, A.; White, J. T.; Whiteson, D.; Wightman, J. A.; Wijngaarden, D. A.; Willis, S.; Wimpenny, S.; Wirjawan, J. V.D.; Womersley, J.; Wood, D.; Yamada, R.; Yamin, P.; Yasuda, T.; Yip, K.; Youssef, S.; Yu, J.; Yu, Z.; Zanabria, M.; Zheng, Hua; Zhou, Z.; Zhu, Z. H.; Zieliński, M.; Ziemińska, D.; Ziemiński, A.; Zutshi, V.; Zverev, E. G.; Zylberstejn, A.

doi:10.1103/physrevlett.86.1156

Cited by 76 publications

(22 citation statements)

References 30 publications

(28 reference statements)

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“…KLF6 is a tumor suppressor gene that is frequently inactivated by loss of heterozygosity (LOH), dysregulated alternative splicing, somatic mutation, and decreased expression in human cancer (9). In the field of lung cancer, several microarray studies have identified KLF6 (usually referred to in these reports as COPEB) as significantly dysregulated in tumors relative to normal tissue and/or as a contributor to gene signatures that predict patient survival (10)(11)(12). In addition, KLF6 expression was found to be significantly decreased in patient-derived lung adenocarcinoma samples compared with matched normal lung tissue in several recent studies by quantitative real-time PCR (qRT-PCR) (13).…”

Section: Introductionmentioning

confidence: 99%

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

Sangodkar¹,

Dhawan²,

Melville³

et al. 2012

J. Clin. Invest.

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EGFR activation is both a key molecular driver of disease progression and the target of a broad class of molecular agents designed to treat advanced cancer. Nevertheless, resistance develops through several mechanisms, including activation of AKT signaling. Though much is known about the specific molecular lesions conferring resistance to anti-EGFR-based therapies, additional molecular characterization of the downstream mediators of EGFR signaling may lead to the development of new classes of targeted molecular therapies to treat resistant disease. We identified a transcriptional network involving the tumor suppressors Krüppel-like factor 6 (KLF6) and forkhead box O1 (FOXO1) that negatively regulates activated EGFR signaling in both cell culture and in vivo models. Furthermore, the use of the FDA-approved drug trifluoperazine hydrochloride (TFP), which has been shown to inhibit FOXO1 nuclear export, restored sensitivity to AKT-driven erlotinib resistance through modulation of the KLF6/FOXO1 signaling cascade in both cell culture and xenograft models of lung adenocarcinoma. Combined, these findings define a novel transcriptional network regulating oncogenic EGFR signaling and identify a class of FDA-approved drugs as capable of restoring chemosensitivity to anti-EGFR-based therapy for the treatment of metastatic lung adenocarcinoma.

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Section: Introductionmentioning

confidence: 99%

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

Sangodkar¹,

Dhawan²,

Melville³

et al. 2012

J. Clin. Invest.

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show abstract

“…The lower limits at 95 % C.L. on the M D scale was given between 1.0 and 1.1 TeV with λ = 1 and −1 , respectively [21]. In (Fig.5), we see the exclusion bound for M D scale with respect to the softening scale and number of extra dimensions for the data.…”

Section: Collider Boundsmentioning

confidence: 71%

Implication of Brane fluctuations to indirect collider signals

Park

Song

2003

J. High Energy Phys.

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Abstract:We study the effect of brane fluctuation on the indirect signals of high energy colliders. Brane fluctuation could act as a regulator of divergent expression of infinite tower of Kaluza-Klein graviton effects. The phenomenological parameter λ, introduced by Hewett, is shown to be determined in our setting, and its dramatic behaviors depending on the D = 4 + δ dimensional gravitation scale M D , 'softening parameter' ∆, and √ s of collider are presented. The present exclusion bounds from the processes e + e − → γγ and pp → e + e − , γγ(γ) are considered within the parameter space (M D , ∆) with respect to the number of extra dimensions.

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“…Present results are shown in Table 2, where it is also possible to find the prospects for LHC [5]. However, in contrast to branon direct production, current measurements by CMS or ATLAS detectors are not able to improve the limits obtained with data coming from HERA [24], Tevatron [25] and LEP [26].…”

Section: Colliders Searches At the Lhcmentioning

confidence: 99%

Impact of dark matter direct searches and the LHC analyses on branon phenomenology

2011

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Dark Matter direct detection experiments are able to exclude interesting parameter space regions of particle models which predict an important amount of thermal relics. We use recent data to constrain the branon model and to compute the region that is favored by CDMS measurements. Within this work, we also update present colliders constraints with new studies coming from the LHC. Despite the present low luminosity, it is remarkable that for heavy branons, CMS and ATLAS measurements are already more constraining than previous analyses performed with TEVATRON and LEP data. pacs 95.35

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Search for Large Extra Dimensions in Dielectron and Diphoton Production

Cited by 76 publications

References 30 publications

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

Implication of Brane fluctuations to indirect collider signals

Impact of dark matter direct searches and the LHC analyses on branon phenomenology

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