Crop yield results from the complex interaction between genotype, management, and environment. While farmers have control over what genotype to plant, and how to manage it, their decisions are often sub-optimal due to climate variability. Sub-seasonal climate predictions embrace the great potential to improve risk analysis and decision-making. However, adequate frameworks integrating future weather uncertainty to predict crop outcomes are lacking. Maize (Zea mays L.) yields are highly sensitive to weather anomalies, and very responsive to plant density (plants m-2), thus this variable could be optimized conditional to the seasonal prospects. The aims of this study were to (i) design a model that describes the yield-to-plant density (herein termed as yield-density) relationship as a function of weather variables, (ii) evaluate the predictive performance and analyze the sources of uncertainty, and (iii) provide probabilistic forecasts for predicting the economic optimum plant density (EOPD). We present a novel approach to enable decision-making in agriculture using sub-seasonal climate predictions and Bayesian modeling. This model provides crop management recommendations by accounting for various sources of uncertainty. A Bayesian hierarchical shrinkage model was fitted to the response of maize yield-density trials performed during the 2010-2019 period across 7 states in the United States, identifying the relative importance of key weather, crop, and soil variables. Tercile forecasts of precipitation and temperature from the International Research Institute (IRI) were used to forecast EOPD before the start of the season. The variables with the greatest influence on the yield-density relationship were weather anomalies, especially months with above-normal temperatures. Improvements on climate forecasting may also improve precision, as the coefficient of determination (R2) increased from 0.26 to 0.32 when weather forecasts were correct. This study may contribute to the development of decision-support tools that can trigger discussions between farmers and consultants about management strategies and their associated risks.