Seasonal Dietary Shifts Alter the Gut Microbiota of Avivorous Bats: Implication for Adaptation to Energy Harvest and Nutritional Utilization

Gong, Lixin; Liu, Boyu; Wu, Hui; Jiang, Feng; Jiang, Tinglei

doi:10.1128/msphere.00467-21

Cited by 25 publications

(16 citation statements)

References 56 publications

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“…The ratio of protein in food also showed an upward trend from SW to SK to PP ( Supplementary Table 1 ). Therefore, these results implied that the higher Firmicutes-to-Bacteroidetes ratio may help SK and PP to obtain more energy from a protein-rich diet ( De Filippo et al, 2010 ; Gong et al, 2021 ). Furthermore, the relative abundance of Cyanobacteria in gut microbes significantly decreased from SW to SK and PP ( Supplementary Table 2 ).…”

Section: Discussionmentioning

confidence: 89%

“…Fish gut microbiota plays an important role in nutrition digestion and absorption ( Wu et al, 2015 ; Liu et al, 2016 ; Li et al, 2017 ). Previous studies have reported that host feeding on more protein may result in a greater Firmicutes-to-Bacteroidetes ratio of the gut microbiome ( De Filippo et al, 2010 ; Gong et al, 2021 ). At the phylum level, we found that the Firmicutes-to-Bacteroidetes ratio exhibited an upward trend from SW to SK and PP ( Supplementary Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…The gut microbial function is of great significance in understanding the mechanism of the host adapting to different diets ( Gong et al, 2021 ). The KEGG pathways (level 2) were enriched in diet-related functional categories, such as carbohydrate metabolism, amino acid metabolism, and lipid metabolism that showed differences between species ( Figure 6 and Supplementary Figure 5 ).…”

Section: Discussionmentioning

confidence: 99%

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Host Species Influence the Gut Microbiota of Endemic Cold-Water Fish in Upper Yangtze River

Peng

Zhang

et al. 2022

Front. Microbiol.

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The fish gut microbiome plays an important role in nutrition absorption and energy metabolism. Studying the gut microbes of cold-water fish is important to understand the dietary adaptation strategies in extreme environments. In this study, the gut samples of Schizothorax wangchiachii (SW, herbivorous), Schizothorax kozlovi (SK, omnivorous), and Percocypris pingi (PP, carnivorous) in the upper Yangtze River were collected, and we sequenced 16S rRNA amplicon to study the potential relationship between gut microbes and host species. The results showed that gut microbial composition and diversity were significantly different between the three cold-water fishes. These fishes had different key taxa in their gut microbes, including bacteria involved in the breakdown of food (e.g., Cetobacterium, Aeromonas, and Clostridium sensu stricto 10). The highest alpha diversity indices (e.g., Chao 1 index) were identified in the herbivore (SW), followed by the carnivore (PP), and the lowest in the omnivore (SK). Non-metric multidimensional scaling (NMDS) results revealed that the gut microbial community of these species was different between host species. The neutral community model (NCM) showed that the microbial community structure of SW was shaped by stochastic processes, and the highest species dispersal was found in SW, followed by PP, and the lowest in SK. The results of niche breadth agreed with these findings. Our results demonstrated that host species influenced the gut microbiome composition, diversity, and microbial community assembly processes of the three cold-water fishes. These findings implied that the variation of gut microbiome composition and function plays a key role in digesting and absorbing nutrients from different foods in cold-water fish.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Host Species Influence the Gut Microbiota of Endemic Cold-Water Fish in Upper Yangtze River

Peng

Zhang

et al. 2022

Front. Microbiol.

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“…The hypervariable region V3-V4 of the bacterial 16S rRNA gene was amplified with primer pairs 338F and 806R (Herlemann et al, 2011). PCR reactions were performed following the protocol described previously (Gong et al, 2021). The PCR product was extracted from 2% agarose gel and purified using the AxyPrep DNA Gel Extraction Kit (Axygen Biosciences, Union City, CA, USA) according to manufacturer's instruc- The raw sequences were merged by FLASH, version 1.2.7 (Magoc & Salzberg, 2011) and imported and processed with The Quantitative Insights into Microbial Ecology Version 2 (QIIME2) for further bioinformatics analysis (Bolyen et al, 2019).…”

Section: S Rrna Gene Sequencingmentioning

confidence: 99%

The gut microbiota of bats confers tolerance to influenza virus (H1N1) infection in mice

Liu

Chen

Zhou

et al. 2022

Transbounding Emerging Dis

Self Cite

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Pathogens from wild animals cause approximately 60% of emerging infectious diseases (EIDs). Studies on the immune systems of natural hosts are helpful for preventing the spread of EIDs. Bats are natural hosts for many emerging infectious pathogens and have a unique immune system that often coexists with pathogens without infection.Previous studies have shown that some genes and proteins may help bats fight virus infection, but little is known about the function of the bat gut microbiome on immunity. Here, we transplanted gut microbiota from wild bats (Great Himalayan Leaf-nosed bats, Hipposideros armiger) into antibiotic-treated mice, and found that the gut microbiota from bats regulated the immune system faster than mice after antibiotic treatment. Moreover, we infected mice with H1N1, and found that the gut microbiota of bats could effectively protect mice, leading to decreased inflammatory response and increased survival rate. Finally, metabolomics analysis showed that the gut microbiota of bats produced more flavonoid and isoflavones. Our results demonstrate that the quick-start innate immune response endowed by bat gut microbiota and the regulatory and antiviral effects of gut microbiota metabolites successfully ensured mouse survival after viral challenge. To our knowledge, our study was the first to use fecal microbiota transplantation (FMT) to transplant the gut microbiota of bats into mice, and the first to provide evidence that the gut microbiota of bats confers tolerance to viral infections.

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“…Several factors influence the colonization of microbial communities in the gut. Host phylogeny, growth stage, diet and health status have been shown to affect the composition and diversity of gut bacterial communities [3,4]. In addition, microorganisms in the external environment may contribute to the establishment of microbial communities in the guts of animals.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Community in the Gut of Neanthes japonica and Its Association with Surrounding Environment

Shang

Li²,

Liu³

et al. 2022

Diversity

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Neanthes japonica has high commercial value. The gut microbes in N. japonica can maintain the normal biological functions of the host. However, information on the gut bacterial community of N. japonica and its relationship with the surrounding environment is unclear. In this study, we used high-throughput sequencing technology to investigate the bacterial communities in the gut of N. japonica and soil. The results showed that the bacterial community diversity and structure differed obviously between the gut and soil samples. Bacterial richness and diversity in the gut samples decreased considerably compared to soil samples. In addition, dominant bacterial taxa varied significantly between the gut and soil samples. The dominant phyla in the gut and soil samples were Proteobacteria, Bacteroidota and Planctomycetota. The dominant genus in the gut was Burkholderia-Caballeronia-Paraburkholderia, while the dominant genera in the soil were Woeseia and Subgroup_23. In conclusion, the similarity between the bacterial communities in soil and the gut of N. japonica was small, indicating that soil had little effect on the establishment of the gut bacterial community. This study provides a better understanding of the gut bacterial community in N. japonica and the influence of the external environment on the colonization of the gut bacterial community.

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Seasonal Dietary Shifts Alter the Gut Microbiota of Avivorous Bats: Implication for Adaptation to Energy Harvest and Nutritional Utilization

Cited by 25 publications

References 56 publications

Host Species Influence the Gut Microbiota of Endemic Cold-Water Fish in Upper Yangtze River

Host Species Influence the Gut Microbiota of Endemic Cold-Water Fish in Upper Yangtze River

The gut microbiota of bats confers tolerance to influenza virus (H1N1) infection in mice

Bacterial Community in the Gut of Neanthes japonica and Its Association with Surrounding Environment

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