Seasonal Influenza Vaccine Effectiveness in Preventing Laboratory Confirmed Influenza in 2014-2015 Season in Turkey: A Test-Negative Case Control Study

Hekimoğlu, Can Hüseyin; Emek, Mestan; Avcı, Emine Özge; Topal, Selmur; Demiröz, Mustafa; Ergör, Gül

doi:10.4274/balkanmedj.2017.0487

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…There are very few reports about influenza vaccination rate in Turkey and vaccination ratio change between 5% and 27% in adult studies 27–29 . Overall influenza vaccination coverage rate was 4.2% according to data of Public Health Institute of Turkey, which is really not sufficient to control the burden of infleunza, 30 although the Global Influenza Hospital Surveillance Network included pediatric cases from Turkey reported that vaccination seemed to confer better protection against influenza B and in children under 4 years of age and prevent approximately one in four hospitalizations with influenza 31 …”

Section: Discussionmentioning

confidence: 96%

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Outcome predictors of influenza for hospitalization and mortality in children

Özsürekçi

Aykaç

Bal

et al. 2021

Journal of Medical Virology

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Severity of disease caused by influenza virus and the influencing factors that may be different. Moreover, the disease course actually may not be determined specifically in children because of lower seroprotection rates of children. Herein, the results clinic and outcome data of children with influenza from Turkey were reported. We present here the results from 2013 to 2017. Nasopharyngeal swab samples of the children with influenza were investigated via multiplex polymerase chain reaction. A total of 348 children were diagnosed with influenza; 143 (41.1%) were influenza A, 85 (24.4%) were influenza B, and 120 (34.5%) were mixt infection with other respiratory viruses. Fifty‐four percent of children admitted to intensive care unit (ICU) were under 2 years of age ( p = .001). Having an underlying disease was detected as the main predictor for both hospitalization and ICU stay according to multiple logistic regression analysis (odds ratio [OR], 11.784: 95% confidence interval [CI], 5.212–26.643; p = .001 and OR, 4.972: 95% CI, 2.331–10.605; p = .001, respectively). Neurological symptoms most frequently seen in cases who died (44.4%; p = .02). Lymphopenia was relatively higher (55.6%) and thrombocytopenia was most frequently seen in cases who died (77.8%) with a significant ratio ( p = .001). Underlying diseases was found a risk factor for influenza being hospitalized and being admitted to ICU. Children under 2 years of age and with underlying diseases should be vaccinated particularly in countries where the influenza vaccination is still not routinely implemented in the immunization schedule. Highlights Underlying diseases is a risk factor for influenza to be hospitalized and admitted to ICU. Influenza vaccination is of great importance to prevent life‐threatening complications of influenza, particularly in children require ICU admission. The possibility to reduce the outpatient visit number by vaccination has a great impact on disease burden in addition to the underestimated crucial social benefits, as well.

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Section: Discussionmentioning

confidence: 96%

“…nation coverage rate was 4.2% according to data of Public Health Institute of Turkey, which is really not sufficient to control the burden of infleunza,30 although the Global Influenza Hospital…”

mentioning

confidence: 98%

Outcome predictors of influenza for hospitalization and mortality in children

Özsürekçi

Aykaç

Bal

et al. 2021

Journal of Medical Virology

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“…33 Overall, influenza vaccination coverage rate was 4.2% in Turkey according to data of the Public Health Institute of Turkey. 34 Influenza is still not included in the national immunization schedule of Turkey. Unfortunately, no other information related to the vaccination of the patients in this study was obtained.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Influenza Patients Admitted in 2019–2020 Flu Season

Gündüz

Ataş

Ünay

et al. 2022

J Pediatr Infect Dis

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Objective Influenza viruses are among the most common respiratory pathogens for all age groups, and may cause seasonal outbreaks. The aim of our study was to describe the clinical characteristics of influenza cases in the 2019–2020 flu season and to study the risk factors for hospital admission and complications. Methods This was a retrospective study in 251 children (group 1: nonhospitalized; group 2: hospitalized) with influenza in the 2019–2020 flu season. Data on demographic features, influenza type, complaints, complications, and hospitalization length were collected and recorded. Results Influenza A was detected in 199 (79.3%) patients, and influenza B was detected in 52 (20.7%); 43.4% of patients were girls and 56.6% were boys. The mean age of the patients was 3.91 ± 3.3 years (16 days to 18 years). A total of 52 (20.7%) patients were hospitalized. The age of the patients in group 2 was lower than that in group 1 (3.1 vs. 4.2 years, p = 0.03). Group 2 patients were more likely to have creatine kinase (CK) elevation, febrile seizures, and physical examination abnormalities. Group 2 patients were also more likely to have influenza A. Patients with febrile seizures, chronic diseases, abnormal physical examination findings, developed complications, and additional drug use apart from oseltamivir in the treatment were also more likely to require hospitalization. Conclusion Infants and children with chronic diseases, history of febrile seizures, complications, and the use of drugs other than antiviral drugs should be carefully evaluated in case they need hospitalization. Increasing vaccination rates, initiation of antiviral treatment for selected patients, and close monitoring of patients in risk groups can decrease morbidity and mortality. Myalgias are a common complaint in patients with acute influenza infection. Previous studies suggest CK measurement be part of the work-up for the hospitalized patient with acute influenza infection.

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“…Dari kelima negara, vaksin yang banyak digunakan adalah Trivalent Inactivated Vaccine (TIV). Persentase keefektivan vaksin untuk tipe virus influenza untuk tipe A genotip H1N1 bekisar 54,00% -68,40% dinilai efektif, untuk tipe B bekisar 34,00% -75,00% dinilai efektif tetapi untuk anak -anak di negara bagian Amerika Latin hanya 3% dinilai kurang efektif, dan untuk tipe A genotip H3N2 adalah 43,00% -65,00% dinilai efektif tetapi di negara Thailand pad atahun 2015/2016 sebesar 2% dinilai kurang efektif [16,17,18,19,20]. Keefektivan vaksin ini terjadi pada banyaknya kasus pada tipe -tipe influenza yang terjadi di negara itu, bahwa kasus H1N1 lebih banyak daripada H3N2 jadi dimungkinkan keefektivan vaksin terhadap H3N2 kurang efektif dari H1N1.…”

Section: Bahasanunclassified

Studi Efektivitas Vaksin Influenza: Updated Review

Gwiharto

Suhandi

Alodya

et al. 2021

kesdok

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Influenza is caused by a rapidly mutating viruse that consists of 2 types, namely type A with the H1N1 and H3N2 genotypes and type B. Influenza caused global mortality with 250,000-500,000 death in 2009. The effectiveness of vaccines also changes regarding the mutation of influenza viruses, however, in the development and utilization of influenza vaccines should be supported by the economic status of a country. Up to now, there are many countries that have not prioritized the utilization of influenza vaccines. The target of influenza vaccination are children and adults (> 60 years old). The purpose of this review was to determine the effectiveness of influenza vaccines from various countries and categorized based on their income. This review used Medline, Elsevier, and BMC Public Health as the database with the keywords "Effectiveness" and "Influenza vaccine". Then, the articles are selected based on inclusion and exclusion criteria. Based on the initial search there are 784 articles that match the keywords, and only 13 articles met the criteria. These articles are classified based on the center of the study in order to classify based on their national income; 5 studies in high income countries, 5 studies in upper-middle income countries, 3 studies in lower-middle income countries, and 1 study in low income countries. The results showed that the administration of influenza vaccine in high income and upper-middle income countries is quite effective for type A H1N1 genotypes, where as H3N2 is less effective. In the lower-middle income countries, the utilization of vaccines with type A H3N2 genotypes was effective, however, in the low-income countries, the effectiveness of vaccines has not been justified due to the limited study of type of influenza and the administration of influenza vaccines in those countries.

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Seasonal Influenza Vaccine Effectiveness in Preventing Laboratory Confirmed Influenza in 2014-2015 Season in Turkey: A Test-Negative Case Control Study

Cited by 10 publications

References 21 publications

Outcome predictors of influenza for hospitalization and mortality in children

Outcome predictors of influenza for hospitalization and mortality in children

Evaluation of Influenza Patients Admitted in 2019–2020 Flu Season

Studi Efektivitas Vaksin Influenza: Updated Review

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