2012
DOI: 10.1371/journal.ppat.1002877
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Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection

Abstract: Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa. Bats have been implicated as likely natural reservoir hosts based most recently on an investigation of cases among miners infected in 2007 at the Kitaka mine, Uganda, which contained a large population of Marburg virus-infected Rousettus aegyptiacus fruit bats. Described here is an ecologic investigation of Python Cave, Uganda, where an American and a Dutch tourist acquired Marburg virus infection … Show more

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Cited by 371 publications
(519 citation statements)
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“…The causative agent was identified as Marburg virus. 17,18 Similar cases of hemorrhagic fever were described in 1976 from outbreaks in two neighboring locations: first in southern Sudan and subsequently in northern Zaire, now Democratic Republic of the Congo (DRC). An unknown causative agent was isolated from patients in both outbreaks and was named Ebolavirus after a small river in northwestern DRC.…”
Section: History and Geographic Distributionmentioning
confidence: 72%
“…The causative agent was identified as Marburg virus. 17,18 Similar cases of hemorrhagic fever were described in 1976 from outbreaks in two neighboring locations: first in southern Sudan and subsequently in northern Zaire, now Democratic Republic of the Congo (DRC). An unknown causative agent was isolated from patients in both outbreaks and was named Ebolavirus after a small river in northwestern DRC.…”
Section: History and Geographic Distributionmentioning
confidence: 72%
“…The bat specimen used for discovery is an important consideration, as well as the time of year these specimens are collected, the intervals between collections, the species of bat to be targeted and the ecology of the bat species, especially as not all viruses are continually shed in the population. In the case of Marburg virus, peaks of shedding were seen during birthing seasons as these months coincided with a peak in infection in 6-monthold juvenile bats 20 .…”
Section: Ina L Smithmentioning
confidence: 99%
“…Przedstawicielami następnej rodziny wirusów -Filoviridae -występujących u nietoperzy, są wirusy Marburg i Ebola, wywołujące krwotoczną gorączkę u ludzi (3). Sporadyczne przypadki kliniczne wywołane wirusem Marburg notowano u ludzi pracujących w kopalniach Kitaka w Ugandzie, które są siedliskiem dużej populacji owocożernych nietoperzy (Rousettus aegyptiacus) (3).…”
Section: Artykuł Przeglądowy Reviewunclassified
“…Sporadyczne przypadki kliniczne wywołane wirusem Marburg notowano u ludzi pracujących w kopalniach Kitaka w Ugandzie, które są siedliskiem dużej populacji owocożernych nietoperzy (Rousettus aegyptiacus) (3). Współczesne możliwości komunikacyjne, powszechny i łatwy dostęp do środków transportu spowodowały, że wybuch epidemii w jednym regionie świata stanowi olbrzymie zagrożenie dla populacji ludzkiej w innych regionach kuli ziemskiej.…”
Section: Artykuł Przeglądowy Reviewunclassified