Seasonal superoxide overproduction and endothelial activation in guinea-pig heart; seasonal oxidative stress in rats and humans

Konior, Anna; Klemenska, Emilia; Brudek, Magdalena; Podolecka, Ewa; Czarnowska, E.; Beresewicz, A

doi:10.1016/j.yjmcc.2010.11.010

Cited by 15 publications

(33 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism is still not fully understood and has been related to changes in physical activity. Interestingly, Langendorff-perfused guinea-pig and rat heart preparations generated close to 100% more O 2 c, while human subjects excreted 65% more 8-isoprostane in the summer versus other seasons (105). Inhibitors of NADPH oxidase, xanthine oxidase, and NO synthase prevented seasonal O 2…”

Section: Seasonal Variation Of Vascular Nadph Oxidase Activitymentioning

confidence: 97%

See 1 more Smart Citation

NADPH Oxidases in Vascular Pathology

Konior

Schramm

Cześnikiewicz-Guzik

et al. 2014

Antioxidants & Redox Signaling

Self Cite

397

350

View full text Add to dashboard Cite

show abstract

Section: Seasonal Variation Of Vascular Nadph Oxidase Activitymentioning

confidence: 97%

“…A recent study has reported an interesting phenomenon that could have important implications for studies of vascular NADPH oxidases (105). Activity and expression of vascular NADPH oxidases may vary seasonally in both rats and mice (and possibly in humans).…”

Section: Seasonal Variation Of Vascular Nadph Oxidase Activitymentioning

confidence: 99%

NADPH Oxidases in Vascular Pathology

Konior

Schramm

Cześnikiewicz-Guzik

et al. 2014

Antioxidants & Redox Signaling

Self Cite

397

350

View full text Add to dashboard Cite

show abstract

“…So far, some reports relate to the changes in the breeding activity and animal metabolism [18], others refer to the differences in immune system in birds [19], food-catching activity [20] or reproduction behavior [21]. Nevertheless, the recent study of Konior et al, demonstrated that guinea-pig and rat hearts generate more super oxide anion, and human subjects excrete more 8-isoprostane in the summer compared to other seasons [22]. In contrary to our observations, the conclusions mentioned above indicate that the increase of oxidative stress was characteristic for animals studied in summer in comparison to changes observed for animals tested in winter months.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Seasonal Fluctuations on Rat Liver Mitochondria Response to Tested Compounds— A Comparison between Autumn and Spring. New Insight into Collecting and Interpretation of Experimental Data Originating from Different Seasons

Łabieniec-Watała¹,

Siewiera²

2013

CellBio

View full text Add to dashboard Cite

Seasonal variations play an essential role in the metabolism, behavior and activity of the laboratory animals. This study was aimed to examine whether mitochondrial function can be influenced by the seasonal changes and how large is the impact of these fluctuations on experiments with using animal models and further results interpretation. Liver mitochondria were isolated from male Wistar rats and exposed to calcium ions, PAMAM dendrimers G2.5 or their combination: (Ca 2+ ) and dendrimer. The scientific hypothesis assumed that dendrimer G2.5 is able to limit the detrimental effect of Ca 2+ ions on mitochondria function, possibly through affecting the following parameters: calcium transport, mitochondrial potential and membrane fluidity. The activity of mitochondria was monitored using fluorescent labels. The changes in calcium transport were detected using Calcium Green 5-N, the mitochondrial membrane potential and membrane fluidity were elucidated using JC-1 and DPH, respectively. The experiments were carried out during the autumn (October/November) or during the spring (May/June). The obtained data emphasize the effect of seasonal differences on liver mitochondria originating from laboratory animals and outline the importance of planning the experiments during the same seasonal period in order to receive objective and reliable results in the future. Finally, it was revealed the neutral effect of G2.5 dendrimer on mitochondria and its inability to protect mitochondria against overload of calcium ions regardless of seasonality. It was also evidenced that liver mitochondria isolated from autumn-derived animals were more sensitive to calcium and/or dendrimer exposure in comparison with mitochondria isolated from animals investigated during the spring.

show abstract

“…The EBC 8-isoprostane levels are significantly higher in children with asthma than in healthy children (13-16). Another well-documented factor with potential clinical relevance is the seasonality of oxidative stress (17,18).The pathophysiology of allergic respiratory diseases is characterized mainly by the secretion of inflammatory mediators (histamine, prostaglandin, cytokines, and leukotrienes) by various cell types (19,20). Cysteinyl leukotriene is an eicosanoid derived mainly from linoleic acids.…”

mentioning

confidence: 99%

“…The EBC 8-isoprostane levels are significantly higher in children with asthma than in healthy children (13)(14)(15)(16). Another well-documented factor with potential clinical relevance is the seasonality of oxidative stress (17,18).…”

mentioning

confidence: 99%

Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children

et al. 2013

View full text Add to dashboard Cite

Background: Cysteinyl leukotrienes are important mediators of airway inflammation, whereas 8-isoprostane is a biomarker of oxidative stress. This study evaluated the distributions of cysteinyl leukotriene and 8-isoprostane concentrations in exhaled breath condensates (EBCs) of children. The relationship between cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs was also evaluated. Methods: The EBCs were collected from 34 children with allergic respiratory diseases and 24 healthy children. All recruited children underwent pulmonary function testing every season. The severity of allergic respiratory diseases and medication status were assessed every month in children with allergic respiratory diseases. results: The EBC cysteinyl leukotriene and 8-isoprostane levels were higher in children with asthma and allergic rhinitis than in those with asthma only and healthy children. In asthmatic children, cysteinyl leukotriene and 8-isoprostane levels peaked in the summer. All children showed a clear association between EBC cysteinyl leukotriene and EBC 8-isoprostane levels. conclusion: The cysteinyl leukotriene and 8-isoprostane concentrations in the EBCs of children significantly varied by season. Oxidative stress correlated with airway inflammation in children. t he prevalence of allergic respiratory diseases is gradually increasing. In Taiwan children aged 6-8 years, the prevalence of asthma and allergic rhinitis is 10.4-12.2 and 24.6-31.4%, respectively (1,2). In school children, asthma symptoms usually appear in the summer and winter seasons whereas those of allergic rhinitis mainly appear in the winter (1,2). Besides seasonal change, risk factors for allergic respiratory diseases include allergens and air pollutants (3).As asthma and allergic rhinitis often coexist in the same patient, both conditions might result from the same disease as suggested by the concept of "one airway, one disease" (4). The pathogenesis of asthma and allergic rhinitis in humans mainly involves airway inflammation (3). In vivo, studies show that increased oxidative stress on the respiratory system causes airway obstruction, excess mucus secretion, and airway inflammation (5,6). Hence, airway oxidative stress is a potential indicator of the severity and prognosis of airway inflammation (6). An important biomarker of oxidative stress is 8-isoprostane, which is a prostaglandin-like compound produced in vivo by the free radical-catalyzed peroxidation of arachidonic acid. This compound has been detected in human urine and exhaled breath condensate (EBC) samples (7,8). Concentrations of EBC 8-isoprostane increase with age in healthy adults (9) and are elevated in asthmatic adults (10,11). Concentrations of 8-isoprostane in EBCs are also higher in severe asthmatics as compared with mild and moderate asthmatics and healthy adults (6,12). The EBC 8-isoprostane levels are significantly higher in children with asthma than in healthy children (13-16). Another well-documented factor with potential clinical relevance is the seasonality of...

show abstract

Seasonal superoxide overproduction and endothelial activation in guinea-pig heart; seasonal oxidative stress in rats and humans

Cited by 15 publications

References 34 publications

NADPH Oxidases in Vascular Pathology

NADPH Oxidases in Vascular Pathology

The Impact of Seasonal Fluctuations on Rat Liver Mitochondria Response to Tested Compounds— A Comparison between Autumn and Spring. New Insight into Collecting and Interpretation of Experimental Data Originating from Different Seasons

Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children

Contact Info

Product

Resources

About