Seasonal variability of oxidative stress markers in city bus drivers

Rössner, Pavel; Švecová, Vlasta; Milcová, Alena; Lnenickova, Zdena; Solanský, Ivo; Šrám, Radìm J.

doi:10.1016/j.mrfmmm.2008.03.004

Cited by 56 publications

(50 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In occupational exposure studies, 8-oxodG levels in urine correlated with exposure to benzene [ 61 , 62 ]; another study [ 63 ] reported a positive correlation between air benzene and 8-oxodG in lymphocytes. In the study by Rossner et al [ 59 ], 8-oxodG levels were not affected by VOC, probably due to the relatively low environmental concentrations of these pollutants.…”

Section: Oxidative Damage To Dnamentioning

confidence: 83%

“…Others did not see any correlation between 8-oxodG levels and urinary 1-hydroxypyrene and/or PAH levels in the air [ 56 -58 ]. Similarly, Rossner et al [ 59 ] did not fi nd any effect of either personal or stationary c-PAH exposure on 8-oxodG levels in urine. These observations suggest that while c-PAHs may have the potential to induce oxidative DNA damage, other factors probably play a role in the response of the organism to environmental pollution.…”

Section: Oxidative Damage To Dnamentioning

confidence: 89%

“…Differences in the chemical composition of PM have been shown to be very important for the induction of DNA damage [ 67 ]. Thus, differences in PM quantities and composition may explain why the results of both studies [ 59 ] and [ 64 ] differ.…”

Section: Oxidative Damage To Dnamentioning

confidence: 99%

See 2 more Smart Citations

Environmental Pollution and Health Consequences

RossnerJr.

Šrám

2014

Studies on Pediatric Disorders

Self Cite

View full text Add to dashboard Cite

Section: Oxidative Damage To Dnamentioning

confidence: 83%

Section: Oxidative Damage To Dnamentioning

confidence: 89%

See 1 more Smart Citation

Environmental Pollution and Health Consequences

RossnerJr.

Šrám

2014

Studies on Pediatric Disorders

Self Cite

View full text Add to dashboard Cite

“…Each sample will be analyzed in duplicate. The 15-F2t-IsoP concentrations are expressed as pg 15-F2t-IsoP/ml plasma (25).…”

Section: -F2t-isoprostane Immunoassaymentioning

confidence: 99%

Impact of Air Pollution to Genome of Newborns

Šrám

Rössner

Rössnerová

et al. 2016

Cent Eur J Public Health

View full text Add to dashboard Cite

SUMMARYThe Northern Moravia Region is the most polluted region in the Czech Republic by particulate matter (PM 2.5 ) and carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) as benzo [a]pyrene (B[a]P) by heavy industry and local heating. This specific situation was used to study the impact of air pollution on newborns in the exposed Karviná district and control district of České Budějovice. Biological material from newborns and mothers was collected in summer and winter seasons. This project is highly detailed, analyzing the concentrations of PAHs in ambient air and diet, in human breast milk, in the urine of mothers and newborns, using biomarkers of genetic damage as DNA adducts and gene expression analysis, biomarkers of oxidative stress as 8-oxodG adducts and lipid peroxidation (15-F2t-isoprostane immunoassay). All 400 children, for whom the biomarker data at delivery were obtained, will be followed for morbidity up to 2 years of age. The Northern Moravia Region seems to be to be a model area for studying the long-term impact of human health exposure to c-PAHs. Our observations will indicate possible genetic and oxidative damage in newborns, which may significantly affect their morbidity.

show abstract

“…Occupational exposure to combustion products, including polycyclic aromatic hydrocarbons (PAHs) have been associated with increased oxidative stress biomarkers in some, but not all, studies (Rossner et al, 2008;Marie et al, 2009). ROS may be responsible for oxidative changes in lipids (Liu and Meng 2005).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Polycyclic Aromatic Hydrocarbons Associated with Traffic Exhaust: The Increase of Lipid Peroxidation and Reduction of Antioxidant Capacity

Lai

Liou

Jaakkola

et al. 2012

Aerosol Air Qual. Res.

View full text Add to dashboard Cite

This study was carried out to examine the association between exposure to polycyclic aromatic hydrocarbon with traffic exhaust and biomarkers of lipid peroxidation and antioxidant levels among highway toll station workers. We conducted a cross-sectional study of 47 female highway toll station workers exposed to traffic exhausts and 27 female classroom trainees as a reference group. Exposure assessment was based on a biomarker of polycyclic aromatic hydrocarbon exposure, urinary 1-hydroxypyrene-glucuronide (1-OHPG). Urinary isoprostane was assayed as a biomarker of lipid peroxidation, and plasma antioxidative capacity of lipid-soluble substances (ACL) and water-soluble substances (ACW) was measured. The median concentration of urinary isoprostane was higher among the exposed non-smokers (4.63 ng/mL) compared with the reference non-smokers (3.52 ng/mL, difference: 0.91, 95% CI -0.15 to 1.98) (Wilcoxon rank-sum test: p = 0.04). The median concentration of ACW among non-smoking exposed subjects (37.9 μg/mL Trolox equivalent) was lower than that of the reference non-smokers (86.3 μg/mL). Adjusting for confounding effects by linear regression, a change in log(isoprostane) concentration was significantly related to a unit change in log(1-OHPG) (regression coefficient [ß], β = 0.14, 95% CI 0.07 to 0.21). Exposure to polycyclic aromatic hydrocarbon is associated with increased lipid peroxidation and reduced antioxidative capacity in toll station workers.

show abstract

Seasonal variability of oxidative stress markers in city bus drivers

Cited by 56 publications

References 50 publications

Environmental Pollution and Health Consequences

Environmental Pollution and Health Consequences

Impact of Air Pollution to Genome of Newborns

Exposure to Polycyclic Aromatic Hydrocarbons Associated with Traffic Exhaust: The Increase of Lipid Peroxidation and Reduction of Antioxidant Capacity

Contact Info

Product

Resources

About