Seasonal Variation in Air Particulate Matter (PM<sub>10</sub>) Exposure-Induced Ischemia-Like Injuries in the Rat Brain

Guo, Lin; Li, Ben; Miao, Juanjuan; Yang, Yun; Li, Guangke; Sang, Nan

doi:10.1021/tx500392n

Cited by 35 publications

(20 citation statements)

References 37 publications

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“…The biological mechanisms by which pollutants could promote stroke are complex, and remained to be fully elucidated. In more simplified in vitro studies using cultures of neurons, astrocytes, and microglia have demonstrated increased susceptibility to oxygen and glucose deprivation [ 35 ], alteration in synaptic function [ 36 ] and upregulation in inflammatory cytokines [ 37 ] when exposed to PM air pollutants. However, in vitro studies are frequently performed by directly exposing cells to very high concentrations of PM.…”

Section: Experimental Evidence For the Association Between Air Pollutmentioning

confidence: 99%

Air Pollution and Stroke

2018

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The adverse health effects of air pollution have long been recognised; however, there is less awareness that the majority of the morbidity and mortality caused by air pollution is due to its effects on the cardiovascular system. Evidence from epidemiological studies have demonstrated a strong association between air pollution and cardiovascular diseases including stroke. Although the relative risk is small at an individual level, the ubiquitous nature of exposure to air pollution means that the absolute risk at a population level is on a par with “traditional” risk factors for cardiovascular disease. Of particular concern are findings that the strength of this association is stronger in low and middle income countries where air pollution is projected to rise as a result of rapid industrialisation. The underlying biological mechanisms through which air pollutants exert their effect on the vasculature are still an area of intense discussion. A greater understanding of the effect size and mechanisms is necessary to develop effective strategies at individual and policy levels to mitigate the adverse cardiovascular effects of air pollution.

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Section: Experimental Evidence For the Association Between Air Pollutmentioning

confidence: 99%

Air Pollution and Stroke

2018

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“…Exposure of male rats to PM from pre-natal through adulthood increased cortical levels of the oxidative stress marker malondialdehyde and reduced levels of [superoxide dismutase]/[catalase] (60). In a study of ambient PM 10 exposure in rats, increases in cortical levels of IL-1β, iNOS, COX-2, ICAM-1 were found along with increases in TUNEL staining (78). Exposures of adult mice to re-aerosolized nanoPM increased levels of TNF-α, 4+NHe and 3-NT in olfactory epithelium and levels of IBA-1 in olfactory epithelium and olfactory bulb (79).…”

Section: Potential Mechanisms Of Cognitive Impairmentmentioning

confidence: 99%

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

Allen

Klocke

Morris‐Schaffer

et al. 2017

Curr Envir Health Rpt

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Purpose of review This review sought to address the potential for air pollutants to impair cognition and mechanisms by which that might occur. Recent findings Air pollution has been associated with deficits in cognitive functions across a wide range of epidemiological studies, both with developmental and adult exposures. Studies in animal models are significantly more limited in number, with somewhat inconsistent findings to date for measures of learning, but show more consistent impairments for short term memory. Potential contributory mechanisms include oxidative stress/inflammation, altered levels of dopamine and/or glutamate and changes in synaptic plasticity/structure. Summary Epidemiological studies are consistent with adverse effects of air pollutants on cognition, but additional studies and better phenotypic characterization are needed for animal models, including more precise delineation of specific components of cognition that are affected, as well as definitions of critical exposure periods for such effects and the components of air pollution responsible. This would permit development of more circumscribed hypotheses as to potential behavioral and neurobiological mechanisms.

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“…The pooled relative risks were 1.011 for PM 2.5 , 1.002 for PM 10 , 1.015 for CO, 1.019 for SO 2 and 1.014 for NO 2 , respectively [ 39 ]. And the underlying mechanism by which air pollution exert as a risk factor for ischemic stroke might be that PMs and gaseous air pollutants, such SO 2 and NO 2 could activate astrocytes, disrupt synaptic functions and enhance endothelial and inflammatory responses of the brains [ 40 , 41 , 42 , 43 ]. Thus, to obtain more reliable and precise results, the potential air pollutants confounders should be taken into considerate.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Ambient Ozone on Incidence and Outcomes of Ischemic Stroke in Changzhou, China: A Time-Series Study

Hua²,

Shen

et al. 2017

IJERPH

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The potential beneficial effect of ozone (O3) on stroke had been identified experimentally and clinically, but these effects remain controversial in population-based studies. This study aimed to explore the epidemiological association between O3 and risk of ischemic stroke. Ischemic stroke related health data and air pollution data were obtained from the Center for Disease Control and Prevention and Environmental Monitoring Center in Changzhou between 2015 and 2016, respectively. The associations between the short-term exposure to O3 and daily ischemic stroke onsets and deaths were examined based on time-series generalized additive Poisson model. During the study period, daily ischemic stroke onsets and deaths decreased 0.340% (95% confidence interval (CI) −0.559% to −0.120%) and 0.697% (95% CI −1.103% to −0.290%) with an interquartile range (IQR) (41.1 µg/m3) increase in levels of ambient O3, respectively. The protective effects of O3 were more significant in men and elders and in the cool season than those in women and young people and in the warm season, respectively. The negative association was independent of PM2.5, PM10, SO2, NO2 or CO exposure. Acute O3 exposure was associated with decreased risk of ischemic stroke. These findings will help provide new insights into the relationship between ischemic stroke and ambient O3 concentrations.

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Seasonal Variation in Air Particulate Matter (PM₁₀) Exposure-Induced Ischemia-Like Injuries in the Rat Brain

Cited by 35 publications

References 37 publications

Air Pollution and Stroke

Air Pollution and Stroke

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

Protective Effects of Ambient Ozone on Incidence and Outcomes of Ischemic Stroke in Changzhou, China: A Time-Series Study

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Seasonal Variation in Air Particulate Matter (PM10) Exposure-Induced Ischemia-Like Injuries in the Rat Brain

Cited by 35 publications

References 37 publications

Air Pollution and Stroke

Air Pollution and Stroke

Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings

Protective Effects of Ambient Ozone on Incidence and Outcomes of Ischemic Stroke in Changzhou, China: A Time-Series Study

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Product

Resources

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Seasonal Variation in Air Particulate Matter (PM₁₀) Exposure-Induced Ischemia-Like Injuries in the Rat Brain