Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers

Kanikowska, Dominika; Sugenoya, Junichi; Sato, Maki; Shimizu, Yasuhiko; Ikoma, Yoko; Nishimura, Naoki; Iwase, Satoshi

doi:10.1007/s00484-009-0236-1

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…Other investigators have reported seasonal variations in the incidence of suicide, with higher rates in the warmer months (Preti and Miotto 2000), and a greater frequency of mood disorders during the summer in the Japanese population (Ozaki et al 1995;Okawa et al 1996). In our previous study (Kanikowska et al 2009), we observed significant seasonal differences in the POMS subscales Anger-Hostility (A-H) and Tension-Anxiety (T-A), with higher scores in spring, as well as higher concentrations of adrenocorticotrophic hormone (ACTH) and catecholamine metabolites in summer. This study suggested that higher values of these variables could be explained by thermal All data are present as means±SE; n=6.…”

Section: Discussionmentioning

confidence: 50%

No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers

et al. 2011

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Heat acclimation results in whole body-adaptations that increase heat tolerance, and might also result in changed immune responses. We hypothesized that, after heat acclimation, tumor necrosis factor alpha, interleukin 6 and the lymphocyte count would be altered. Heat acclimation was induced in 6 healthy men by 100 min of heat exposure for 9 days. Heat exposure consisted of (1) 10 min of immersion up to chest-level in water at 42°C and (2) 90 min of passive heating by a warm blanket to maintain tympanic temperature at 37.5°C. The climatic chamber was maintained at 40°C and a relative humidity of 50%. Blood samples were analyzed before and after heat acclimation for natural killer (NK) cell activity, counts of lymphocytes B and T, before and after heat acclimation for peripheral blood morphology, interleukin 6, tumor necrosis factor alpha, and cortisol. A Japanese version of the profile of mood states questionnaire was also administered before and after acclimation. The concentrations of white blood cells, lymphocytes B and T, cortisol, interleukin 6, tumor necrosis factor alpha and NK cell activity showed no significant differences between pre- and post-acclimation, but there was a significantly lower platelet count after acclimation and, with the profile of mood states questionnaire, there was a significant rise in anger after acclimation. It is concluded that heat acclimation by passive heating does not induce alterations in immune or endocrine responses.

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Section: Discussionmentioning

confidence: 50%

No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers

et al. 2011

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“…Levels of blood markers seem to increase mostly during the winter 10 14 15. Hence, changes in blood markers due to temperature changes might precede cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

“…Fibrinogen,6 IL-67 and CRP6–8 are established predictors of cardiovascular risk and IL-6 and CRP seem to be more associated with fatal than non-fatal cardiovascular events 9. Several blood markers like fibrinogen, IL-6 and CRP showed seasonal variations with increases mostly in the cold season10–12 14 15 and might therefore be one possible link to the peak of cardiovascular events in winter. However, in our study, temperature effects were inconsistent between participants with T2D or IGT and participants with a special genetic background.…”

Section: Discussionmentioning

confidence: 99%

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Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals

et al. 2012

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Objectives Changes in air temperature are associated with an increase in cardiovascular events, but the role of procoagulant and proinflammatory blood markers is still poorly understood. The authors investigated the association between air temperature and fibrinogen, plasminogen activator inhibitor type 1, interleukin-6 and high-sensitivity C reactive protein in two potentially susceptible groups. Methods This prospective panel study was conducted between March 2007 and December 2008 in Augsburg, Germany. The study population comprised 187 participants with type 2 diabetes mellitus or impaired glucose tolerance and 87 participants with genetic polymorphisms on the detoxification and inflammation pathways. Overall, 1766 repeated blood measurements were collected. Hourly meteorology data were available from a central measurement site. The association between temperature and blood markers was analysed with additive mixed models. Results For type 2 diabetes mellitus and impaired glucose tolerance participants, the authors observed immediate, lagged and cumulative increases in fibrinogen (range of percentage changes in geometric mean: 0.6%e0.8%) and plasminogen activator inhibitor type 1 (6.0%e10.1%) in association with a 58C temperature decrement. Participants with a body mass index above 30 kg/m 2 as well as females showed particularly strong fibrinogen effects. In participants with the special genetic background, 58C decreases in the 5-day average of temperature led to a change of 8.0% (95% CI 0.5% to 16.2%) in interleukin-6 and of À8.4% (95% CI À15.8% to À0.3%) in high-sensitivity C reactive protein, the latter driven by physically active individuals. Conclusions The authors observed different temperature effects on blood markers in two potentially susceptible groups probably indicating varying underlying biological mechanisms. This study results might provide a link between temperature and cardiovascular events.

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“…However, unlike burn trauma, the IR induced by nonburn trauma and surgery is transient and disappears after nonburn trauma or surgery [32], suggesting the following relationship: a permanent decrease in the skin function is associated with sustained IR, while a transient decrease in the function of intact skin is associated with transient IR. Moreover, the observation that there is an elevation in IR-inducing substances [33] and blood pressure [34] and worse symptoms of IR-related diseases [35, 36] in winter might also imply a close association between the skin function and IR, since low ambient temperature exposure reduces the blood flow to the skin and the skin temperature [37]. …”

Section: Discussionmentioning

confidence: 99%

Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance

Liu

Sun

Yang

et al. 2012

Experimental Diabetes Research

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The skin, the body's largest organ, plays an important role in the biotransformation/detoxification and elimination of xenobiotics and endogenous toxic substances, but its role in oxidative stress and insulin resistance is unclear. We investigated the relationship between skin detoxification and oxidative stress/insulin resistance by examining burn-induced changes in nicotinamide degradation. Rats were divided into four groups: sham-operated, sham-nicotinamide, burn, and burn-nicotinamide. Rats received an intraperitoneal glucose injection (2 g/kg) with (sham-nicotinamide and burn-nicotinamide groups) or without (sham-operated and burn groups) coadministration of nicotinamide (100 mg/kg). The results showed that the mRNA of all detoxification-related enzymes tested was detected in sham-operated skin but not in burned skin. The clearance of nicotinamide and N 1-methylnicotinamide in burned rats was significantly decreased compared with that in sham-operated rats. After glucose loading, burn group showed significantly higher plasma insulin levels with a lower muscle glycogen level than that of sham-operated and sham-nicotinamide groups, although there were no significant differences in blood glucose levels over time between groups. More profound changes in plasma H2O2 and insulin levels were observed in burn-nicotinamide group. It may be concluded that decreased skin detoxification may increase the risk for oxidative stress and insulin resistance.

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Seasonal variation in blood concentrations of interleukin-6, adrenocorticotrophic hormone, metabolites of catecholamine and cortisol in healthy volunteers

Cited by 15 publications

References 40 publications

No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers

No effects of acclimation to heat on immune and hormonal responses to passive heating in healthy volunteers

Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals

Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress and Insulin Resistance

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