Seasonal variation in metabolic syndrome prevalence

Kamezaki, Fumihiko; Sonoda, Shinjo; Tomotsune, Yusuke; Yunaka, Hiromi; Otsuji, Yutaka

doi:10.1038/hr.2010.32

Cited by 58 publications

(49 citation statements)

References 20 publications

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“…potentiating insulin resistance). Moreover, it must be appreciated that this seasonal mechanism for regulating metabolism that has been preserved over hundreds of millions of years of evolution is also manifested in man, as multiple studies have clearly demonstrated [66][67][68][69][70][71][72][73][74][75].…”

Section: Role Of the Biological Clock (Scn) And Circadian Rhythms In mentioning

confidence: 99%

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

Raskin

Cincotta

2016

Expert Review of Endocrinology & Metabolism

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An extended series of studies indicate that endogenous phase shifts in circadian neuronal input signaling to the biological clock system centered within the hypothalamic suprachiasmatic nucleus (SCN) facilitates shifts in metabolic status. In particular, a diminution of the circadian peak in dopaminergic input to the peri-SCN facilitates the onset of fattening, insulin resistance and glucose intolerance while reversal of low circadian peak dopaminergic activity to the peri-SCN via direct timed dopamine administration to this area normalizes the obese, insulin resistant, glucose intolerant state in high fat fed animals. Systemic circadian-timed daily administration of a potent dopamine D2 receptor agonist, bromocriptine, to increase diminished circadian peak dopaminergic hypothalamic activity across a wide variety of animal models of metabolic syndrome and type 2 diabetes mellitus (T2DM) results in improvements in the obese, insulin resistant, glucose intolerant condition by improving hypothalamic fuel sensing and reducing insulin resistance, elevated sympathetic tone, and leptin resistance. A circadian-timed (within 2 hours of waking in the morning) once daily administration of a quick release formulation of bromocriptine (bromocriptine-QR) has been approved for the treatment of T2DM by the U.S. Food and Drug Administration. Clinical studies with such bromocriptine-QR therapy (1.6 to 4.8 mg/day) indicate that it improves glycemic control by reducing postprandial glucose levels without raising plasma insulin. Across studies of various T2DM populations, bromocriptine-QR has been demonstrated to reduce HbA1c by -0.5 to -1.7. The drug has a good safety profile with transient mild to moderate nausea, headache and dizziness as the most frequent adverse events noted with the medication. In a large randomized clinical study of T2DM subjects, bromocriptine-QR exposure was associated with a 42% hazard ratio reduction of a pre-specified adverse cardiovascular endpoint including myocardial infarction, stroke, hospitalization for congestive heart failure, revascularization surgery, or unstable angina. Bromocriptine-QR represents a novel method of treating T2DM that may have benefits for cardiovascular disease as well. ARTICLE HISTORY

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Section: Role Of the Biological Clock (Scn) And Circadian Rhythms In mentioning

confidence: 99%

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

Raskin

Cincotta

2016

Expert Review of Endocrinology & Metabolism

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“…Thus, it appears that the seasonal effect has a clear impact. In this issue of Hypertension Research, Kamezaki et al 7 show that serum levels of high-density lipoprotein cholesterol, fasting glucose and systolic and diastolic blood pressures are higher in winter than in summer. Furthermore, these seasonal fluctuations influence the assessment and prevalence of the metabolic syndrome.…”

Section: Isruption Of Endogenous Rhythms Hasmentioning

confidence: 98%

Metabolic syndrome follows a seasonal cycle

Partonen

2010

Hypertens Res

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D isruption of endogenous rhythms hasbeen implicated in the pathogenesis of metabolic disorders and cardiovascular diseases. 1,2 There are links between metabolic cycles and circadian rhythms, as both oscillations are generated by the circadian clocks. 3,4 Recent findings have extended these links by suggesting that there may also be a relationship between metabolic cycles and seasonal fluctuations. 5,6 It seems that abnormalities in the circadian clock may predispose individuals not only to seasonal variations in mood and behavior but also to the metabolic syndrome. Seasonal variations in mood and behavior, that is, the global seasonality score, have a metabolic factor that is composed of weight and appetite. In particular, this score increases the risk of having the metabolic syndrome. The negative effect of seasonal variations is cancelled out by the protective effect of regular physical exercise in the struggle against the metabolic syndrome. Thus, it appears that the seasonal effect has a clear impact. In this issue of Hypertension Research, Kamezaki et al. 7 show that serum levels of high-density lipoprotein cholesterol, fasting glucose and systolic and diastolic blood pressures are higher in winter than in summer. Furthermore, these seasonal fluctuations influence the assessment and prevalence of the metabolic syndrome. It is important that clinicians and research teams pay close attention to this finding in their future work.Here one is left to ask what causes these metabolic variations to occur; this question is difficult to address. Both light/dark transitions and the photoperiod that guide the circadian clocks are likely to contribute to seasonal changes in these metabolic components. [8][9][10] For example, if the lighting conditions at home are poor, it will negatively impact scores related to the metabolic component of the global seasonality score. 6 Scheduled dynamics of lighting conditions at home or at the work place may therefore serve as a parameter on which intervention could be useful to influence seasonal metabolic signals and, ultimately, to prevent the metabolic syndrome.In summary, the current evidence indicates that (1) seasonal variations of metabolic syndrome components and prevalence do exist, and (2) these variations must be considered at periodic health checkups. Furthermore, because of the ease of assessment, it might be worth determining and integrating the global seasonality score as a routine part of health status examination in persons at risk for, or who currently have, one or more components of the metabolic syndrome. If this change was implemented, effective treatment options such as scheduled exposures to light and regular physical exercise, both of which can help calibrate an individual's circadian clock, need to be considered for prevention and treatment of the metabolic syndrome.

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“…[10], исследовав 1202 японских мужчины среднего возраста (44±10 лет), показали вы-сокую распространенность метаболического синдро-ма в зимний период года. По критериям Национальной образовательной программы по холестеролу (National Cholesterol Education Program Adult Treatment), Между-народной федерации диабета (IDF), японского обще-ства внутренней медицины (Japanese Society of Internal Medicine) распространенность зимой метаболического синдрома составила 3,8%; 15,1% и 12,4%, а летом -3,2%; 10,7% и 8,4% соответственно.…”

Section: биологические неклассические эффекты витамина Dunclassified

Non-classical effects of vitamin D

Ваниковна¹

2018

Obes. metabol.

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1ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России, г. Москва 2 ГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», г. Москва Существуют данные об участии витамина D в модуляции воспалительной реакции и развитии сахарного диабета. Поскольку активация провоспалительных биомаркеров и цитокинов препятствует нормальному обмену веществ и нарушает синтез инсулина и чувствительность тканей к нему, предполагается, что витамин D может влиять на гомеос-таз липидов и глюкозы путем модуляции воспалительной реакции и ренин-ангиотензиновой системы. В статье пред-ставлен обзор литературы, обобщающий данные о механизмах влияния дефицита витамина D на метаболические нарушения.КЛЮЧЕВЫЕ СЛОВА: витамин D, сахарный диабет, инсулинорезистентность, метаболический синдром, ожирение, артериальное давление, ренин-ангиотензиновая система. NON-CLASSICAL EFFECTS OF VITAMIN D© Egshatyan L.V. Since the activation of inflammatory biomarkers, cytokines and pathways interferes with normal metabolism and disrupts proper insulin signaling and insulin resistance, it is hypothesized that vitamin D could influence lipid and glucose homeostasis by modulating inflammatory response and renin-angiotensin system. In this review discussed the mechanisms of the influence of vitamin D on metabolic disease.

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Seasonal variation in metabolic syndrome prevalence

Cited by 58 publications

References 20 publications

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

Metabolic syndrome follows a seasonal cycle

Non-classical effects of vitamin D

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