Seasonal variation in phenolic composition, antibacterial and antioxidant activities of Ulva rigida (Chlorophyta) and assessment of antiacetylcholinesterase potential

Trigui, Mohamed; Gasmi, Laila; Zouari, Imen; Tounsi, Slim

doi:10.1007/s10811-012-9866-5

Cited by 54 publications

(41 citation statements)

References 28 publications

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“…Previous phytochemical studies have demonstrated that the ethanol precipitate extract of U. rigida contains a significant amount of proteins, phenols and polysaccharides (Mezghani et al 2013). These compounds are known to possess remarkable antioxidant capacity (Godard et al 2009;Trigui et al 2012;Yildiz et al 2012).…”

Section: Discussionmentioning

confidence: 99%

The Ethanol Precipitate of U lva rigida Protects HeLa Cells from Hydrogen Peroxide-Induced Apoptosis

Mezghani

N’Guessan

Carrier

et al. 2014

Journal of Food Biochemistry

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Ulva rigida exhibits antioxidant activity that protects against oxidative stress. In the present investigation, we conducted experiments in HeLa cells exposed to hydrogen peroxide (H2O2) and found that the U. rigida ethanolic precipitate inhibited H2O2 apoptosis. This precipitate prevented the H2O2 stress‐induced decline in the mitochondrial membrane potential (MMP). P21 Bax expression was decreased in H2O2‐treated cells compared with untreated cells. Conversely, p21 Bax was consistently detected in cells that were co‐treated with H2O2 and the U. rigida ethanolic precipitate. Bcl‐xL expression increased in cells co‐treated with H2O2 and the U. rigida ethanolic precipitate compared with H2O2‐treated cells. Based on the obtained results, H2O2‐induced apoptosis was inhibited by the U. rigida ethanol precipitate early in the apoptotic process through the upregulation of Bcl‐xL, the prevention of full‐length Bax cleavage molecule and the subsequent inhibition of MMP loss, which is a crucial step in the apoptotic cascade. Practical Applications Increasing evidence from both experimental and clinical studies has suggested that oxidative stress plays a major role in aging and pathogenesis. Currently, the search for safe and efficacious medicinal plants that possess antioxidant activity has attracted particular interest. In this context, this is the first report on the antioxidant activity of Ulva rigida in a cell line: U. rigida protected the cells from oxidative stress‐induced apoptosis. The U. rigida ethanol precipitate inhibited apoptosis via the upregulation of Bcl‐xL, the prevention of full‐length Bax cleavage to its short and potent form, and the subsequent inhibition of the loss of the mitochondrial membrane potential. Herein, we report the mechanism by which U. rigida protects against oxidative stress‐induced apoptosis. This may provide knowledge to enable the development of novel therapeutic strategies using U. rigida compounds to treat diseases that are attributed to oxidative disorders.

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Section: Discussionmentioning

confidence: 99%

The Ethanol Precipitate of U lva rigida Protects HeLa Cells from Hydrogen Peroxide-Induced Apoptosis

Mezghani

N’Guessan

Carrier

et al. 2014

Journal of Food Biochemistry

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“…Crude extracts of Ulva spp. samples often displayed positive antibacterial and/or antifungal activities for samples collected from different parts of the world [12][13][14]. In some studies, the actives compounds have been isolated and identified.…”

Section: Antibacterial and Antifungalmentioning

confidence: 99%

Pharmacological Potential of Ulva Species: A Valuable Resource

Ktari¹

2017

JAPLR

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With the emergence of new diseases, the increase of pathogenic strains resistance and the apprehensiveness of synthetic compounds side effects, there is a constant need to find natural and low toxicity drug candidates. Seaweeds are rich source of original and bioactive natural substances. In particular, species of the genus Ulva have been demonstrated to metabolize biomolecules with pharmacological potential. This mini review present some of the biological properties reported for Ulva spp.

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“…Similar fi ndings were reported by Tan et al (2012) where antimicrobial activity from seaweeds collected in Ireland showed the lowest activity in spring/summer and the highest in autumn/winter. Trigui et al (2012) reported that the biological properties of Ulva rigida collected over 12 months from Sidi Mansour Sfax (Tunis) revealed strong antimicrobial and antioxidant properties for samples collected during spring. Similar to seasonality, the geographical location of seaweeds also infl uence their antimicrobial effi cacy.…”

Section: Natural Factorsmentioning

confidence: 99%

“…These methods are widely used to screen seaweed extracts for antimicrobial activity (Rajauria et al , 2012;Trigui et al , 2012;Pierre et al , 2011;Vijayabaskar and Shiyamala, 2011). However, diffusion techniques are suitable for preliminary screening and ideally can only be used for antimicrobial susceptibility testing of pure substances rather than mixtures containing constituents which tend to exhibit different diffusion rates thus causing possible unreliability of the obtained results (Silva et al , 2005).…”

Section: Antimicrobial Susceptibility Testingmentioning

confidence: 99%