Seasonal variation of 1,25-dihydroxyvitamin D and its association with body mass index and age

Moan, Johan Emelian; Lagunova, Zoya; Lindberg, Fedon A.; Porojnicu, Alina Carmen

doi:10.1016/j.jsbmb.2009.01.001

Cited by 42 publications

(40 citation statements)

References 45 publications

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“…Obese patients who have less mobility and more cosmetic problems, may have less exposure to sunlight and consume food having less Vit D. It was also been shown that in obese patients renal 1 alpha hdroxylase activity was increased and there was a passing defect of Vitamin D from the skin into the circulation. 57 The idea of Vit D being inversely related to obesity was also supported by various studies like ours. 58,59 But as Vit D supplementation is not likely to lead weight loss we think that this relationship is not in a casual manner.…”

Section: Discussionsupporting

confidence: 67%

The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Atalay¹,

Korlaelçi²,

Gürsoy³

et al. 2017

World Clin J Med Sci

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Section: Discussionsupporting

confidence: 67%

The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Atalay¹,

Korlaelçi²,

Gürsoy³

et al. 2017

World Clin J Med Sci

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“…Moreover, obese individuals with less mobility and more cosmetic problems might have less exposure to sunlight, they consume foods having less Vit D. It have also been thought that in obese patients renal 1 alpha hdroxylase activity was increased and there was a passing defect of Vitamin D from the skin into the circulation. 45 In our study in patients with MS, BMI and waist circumference were higher than in individuals without MS. We also showed that as Vit D levels increased BMI and waist circumference values decreased. In Vit D <10ng/mL and 10-20 ng/mL groups BMI and waist circumference were significantly higher than Vit D > 30 ng/mL group.…”

Section: Resultscontrasting

confidence: 39%

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Evrim¹,

Atalay²,

Gürsoy³

et al. 2016

Turkiye Klinikleri J Endocrin

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A AB BS S TTR RA AC CT T O Ob bj je ec ct ti iv ve e: : Hypovitaminosis D and metabolic syndrome are worldwide common problems. The link between them was unresolved. We planned to define the relation between Vitamin D levels and metabolic syndrome and also their parameters. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We evaluated all the demographic and anthropometric parameters of 79 healthy participants and 95 patients with metabolic syndrome and compared those parameters and vitamin D levels. We classified 25(OH)D serum levels; <10ng/mL as serious deficiency, 10-20 ng/mL as deficiency, 20-30 ng/mL insufficiency and > 30 ng/mL as normal status. We searched the correlation of vitamin D levels with metabolic syndrome parameters. We also examined the relation of various Vitamin D levels with demographic and anthropometric findings of metabolic syndrome patients. R Re es su ul lt ts s: : Vitamin D levels were low in all the individuals (12.8 ± 6.7ng/mL in patients and 19.0 ± 10.0ng/mL in controls. p<0.001). In metabolic syndrome patients, serious deficiency was high and normal Vit D status was significantly low especially in females. In metabolic syndrome group vitamin D levels were negatively correlated with body mass index, waist circumference, blood glucose, hemoglobin A1c, fasting insulin, insulin resistance index (p <0.012, <0.040, <0.002, <0.008, <0.006, <0.001 respectively). We found that vitamin D levels of the patients without hypertension, diabetes mellitus, dyslipidemia or obesity were higher than that of the patients with those diseases among metabolic syndrome group (all p<0.001). We also demonstrated as Vitamin D levels decreased, rate of obesity, hypertension and diabetes mellitus increased, (p<.0.029, <0.035 and <0.001 respectively). C Co on nc cl lu us si io on n: : In patients with metabolic syndrome hypovitaminosis D is frequent especially in women. As Vitamin D levels are in negative correlation with obesity, diabetes and insulin resistance indices and also with metabolic syndrome parameters, we concluded that Vitamin D supplementation is important in hypovitaminosis D cases with metabolic syndrome. Ya zış ma Ad re si/Cor res pon den ce:

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“…Evidence for the negative feedback from increased circulating 1,25(OH)D concentrations in obesity is equivocal. As introduced earlier, when required by the body, 25(OH)D is further hydroxylated to form the active metabolite, 1,25(OH)D, which in turn 'switches off' the production of 25(OH)D. Indeed, increased 1,25(OH)D, and therefore decreased 25(OH)D concentration, in obese compared with non-obese subjects was reported in earlier smaller studies (20,21) , but more recently, larger studies show the opposite is true (22)(23)(24)(25) . Data supporting this mechanism remain inconclusive.…”

Section: Commonly Suggested Mechanismsmentioning

confidence: 93%

Vitamin D and obesity: current perspectives and future directions

2014

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In recent years, new functional roles of vitamin D beyond its traditional role in calcium homoeostasis and bone metabolism have emerged linking the fat-soluble vitamin to various non-communicable diseases. Vitamin D deficiency (25-hydroxyvitamin D (25(OH)D) < 25-30 nmol/l) and sub-optimal status (25(OH)D < 50-100 nmol/l) are increasingly associated with unfavourable metabolic phenotypes, including insulin resistance, type 2 diabetes and CVD; conditions also commonly linked with overweight and obesity. Early studies reported poor vitamin D status in the morbidly obese. More recently, it has been observed that a graded relationship between vitamin D status and BMI, or specifically adiposity, exists in the general population. A number of hypotheses have been proposed to explain the potential mechanisms whereby alterations in the vitamin D endocrine system occur in the obese state. Plausible explanations include sequestration in adipose tissue, volumetric dilution or negative feedback mechanisms from increased circulating 1,25-dihydroxyvitamin D 3 . Others hypothesise that heavier individuals may partake in less outdoor activity, may also cover-up and wear more clothing than leaner individuals, thus decreasing sun exposure and limiting endogenous production of cholecalciferol in the skin. Moreover, in some but not all studies, BMI and adiposity have been negatively associated with the change in vitamin D status following vitamin D supplementation. It therefore remains unclear if body size and/or adiposity should be taken into account when determining the dietary requirements for vitamin D. This review will evaluate the current evidence linking vitamin D status and supplementation to overweight and obesity, and discuss the implications for setting dietary requirements. Vitamin D: Obesity: BMI: Fat mass: Adipose tissueTraditional roles of vitamin D lie within the musculoskeletal system, maintaining calcium homoeostasis and bone metabolism, with deficiency leading to conditions such as rickets in children, or osteoporosis and osteomalacia in adults (1) . However, obesity is now frequently cited as a cause of vitamin D deficiency (2,3) , which may in fact lead to other co-morbidities, such as diabetes and CVD, conditions commonly linked to obesity (4,5) . Indeed, obesity and vitamin D deficiency have concomitantly reached epidemic levels worldwide and research linking the two has grown extensively over the last number of years. It is reasonable to suggest that this nutritional inadequacy may be driven by the increasing obesity rates within the general population, and may therefore improve with a reversal of the latter. However, despite the plethora of evidence available, the mechanisms remain largely unclear and the area of reverse causality is also commonly debated within the literature: does obesity lead to vitamin D deficiency or vice versa?Vitamin D is not technically a vitamin, but is better classified as an active circulating pre-hormone within the body. Limited amounts of vitamin D are obtained from dietary sourc...

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Seasonal variation of 1,25-dihydroxyvitamin D and its association with body mass index and age

Cited by 42 publications

References 45 publications

The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Relationship Between Levels of Vitamin D and Metabolic Syndrome Parameters in Patients with Metabolic Syndrome and Healthy Individuals

Vitamin D and obesity: current perspectives and future directions

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