Seasonal variations in [3H]citalopram platelet binding between healthy controls and violent offenders in Finland

Callaway, J. C.; Storvik, Markus; Halonen, Pirjo; Hakko, Helinä; Räsänen, Pirkko; Tiihonen, Jari

doi:10.1002/hup.712

Cited by 19 publications

(14 citation statements)

References 33 publications

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“…Platelet levels of 5‐HTT exhibit seasonal variations (29). Furthermore, genetic polymorphisms in the promoter as well as in intron regions of the 5‐HTT gene render the individuals involved more prone to stress and depression (30,31).…”

Section: Release and Reuptake Of 5‐htmentioning

confidence: 99%

The skin as a mirror of the soul: exploring the possible roles of serotonin

Nordlind

Azmitia

Slominski

2007

Experimental Dermatology

107

102

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Serotonin (5-hydroxytryptamine; 5-HT) is an important mediator of bidirectional interactions between the neuroendocrine system and the skin. The rate of synthesis of 5-HT from l-tryptophan can be enhanced by brain-derived neuronal growth factor, cytokines, exposure to ultraviolet light and steroids. The major source of 5-HT in the skin are platelets, which, upon aggregation, release this biogenic amine. Moreover, the epidermal and dermal skin express the enzymes required for the transformation of tryptophan to 5-HT, and certain skin cells, such as melanocytes, have been demonstrated to produce 5-HT. In addition, rodent mast cells produce 5-HT, but human mast cells have not yet been fully examined in this respect. Skin cells express functionally active, membrane-bound receptors for 5-HT, as well as proteins that transport 5-HT. The interactions of 5-HT with these various proteins determines the nature, magnitude and duration of serotonergic responses.The immune and vasculature systems in the skin are traditional targets for bioregulation by 5-HT. Moreover, recent findings indicate that keratinocytes, melanocytes and dermal fibroblasts also respond to this amine in various ways. Thus, mammalian skin is both a site for the production of and a target for bioregulation by 5-HT. This indicates that agonists and antagonists directed towards specific 5-HT receptors could be useful in connection with treatment of skin diseases. Based on our increasing knowledge concerning these receptors and their plasticity, future research will focus on the development of serotonergic drugs that exert metabotrophic effects on the cells of the skin without affecting the central nervous system.

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Section: Release and Reuptake Of 5‐htmentioning

confidence: 99%

The skin as a mirror of the soul: exploring the possible roles of serotonin

Nordlind

Azmitia

Slominski

2007

Experimental Dermatology

107

102

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“…A number of studies showed seasonal changes in serotonergic parameters, including brain serotonin concentration and turnover [34][35][36][37][38] . Furthermore, serotonin-related behaviours change with the seasons in clinical and non-clinical populations [34,[39][40][41][42][43][44][45][46][47] . The most important physiological mechanism controlling synaptic serotonin levels is reuptake of serotonin into the presynaptic neuron via the serotonin transporter (5-HTT) [48,49] .…”

Section: Serotoninmentioning

confidence: 99%

Bright-Light Therapy in the Treatment of Mood Disorders

et al. 2011

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Bright-light therapy (BLT) is established as the treatment of choice for seasonal affective disorder/winter type (SAD). In the last two decades, the use of BLT has expanded beyond SAD: there is evidence for efficacy in chronic depression, antepartum depression, premenstrual depression, bipolar depression and disturbances of the sleep-wake cycle. Data on the usefulness of BLT in non-seasonal depression are promising; however, further systematic studies are still warranted. In this review, the authors present a comprehensive overview of the literature on BLT in mood disorders. The first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the suprachiasmatic nucleus (SCN), the indolamines melatonin and serotonin, and the chronobiology of mood disorders. The SCN is the primary oscillator in humans. Indolamines are known to transduce light signals into cells and organisms since early in evolution, and their role in signalling change of season is still preserved in humans: melatonin is synthesized primarily in the pineal gland and is the central hormone for internal clock circuitries. The melatonin precursor serotonin is known to modulate many behaviours that vary with season. The second part discusses the pathophysiology and clinical specifiers of SAD, which can be seen as a model disorder for chronobiological disturbances and the mechanism of action of BLT. In the third part, the mode of action, application, efficacy, tolerability and safety of BLT in SAD and other mood disorders are explored.

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“…[3][4][5][6][7][8][9][10][11][12] Seasonal variations in peripheral serotonergic markers have been demonstrated in several studies. [12][13][14] A postmortem study 15 shows seasonal differences in serotonin concentration in the human hypothalamus; another study 16 suggests that sunlight alters serotonin turnover in the human brain.…”

mentioning

confidence: 99%