Seasonal variations of the composition and structural characteristics of polysaccharides from the brown alga Costaria costata

Имбс, Т. И.; Шевченко, Н. М.; Sukhoverkhov, S. V.; Semenova, T. L.; Скрипцова, А. В.; Zvyagintseva, T. N.

doi:10.1007/s10600-010-9507-7

Cited by 61 publications

(42 citation statements)

References 23 publications

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“…The study of seasonal variations of the polysaccharide composition and structure of individual polysaccharides is of practical significance for determining the optimal times for collecting alga in order to standardize preparations of these polysaccharides for use in medicine and in the food industry. [9][10][11] For this reason, monthly changes in the fucoidan content and its monosaccharide composition were monitored from May to October, and the most fucoidan-rich fraction FL-Jul (95% of fucose, see Table 1) was chosen for structural investigation by mass spectrometry. The structure of a highly sulfated fucan extracted from L. cichorioides (collected in August) was examined previously by our group using chemical and NMR spectroscopic analyses.…”

Section: Resultsmentioning

confidence: 99%

“…3,8 Therefore, it is important to take into consideration that the structure of fucoidans from the same species of alga may differ significantly at different stages of development, [9][10][11] and differ less significantly due to their geographical location. 4 Furthermore, the application of rugged extraction, for example, may affect the polysaccharide composition.…”

Section: Introductionmentioning

confidence: 99%

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Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry

Anastyuk

Шевченко

Nazarenko

et al. 2010

Carbohydrate Research

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry

Anastyuk

Шевченко

Nazarenko

et al. 2010

Carbohydrate Research

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“…The same procedure was used to obtain fucoidans FeF from F. evanescens [34], SgGF from S. gurjanovae [18], AoGF from Al. ochotensis and SjGF from S. japonica [35] and CcGF from C. costata [36]. …”

Section: Methodsmentioning

confidence: 99%

Fucoidans as Potential Inhibitors of HIV-1

et al. 2013

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The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001–100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001–0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.

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“…These compounds exhibit a broad spectrum of biological activity and low in vivo toxicity. Unfortunately, their use is hampered by problems with obtaining products with standard properties because the content and structural characteristics of the polysaccharides vary depending on the habitat and collection season [4]. Furthermore, the relationship between structural features and the biological activity of the polysaccharides, especially fucoidans, is poorly studied.…”

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Seasonal variations of the composition, structural features, and antitumor properties of polysaccharides from Padina pavonica (Lebanon) as a function of composition

et al. 2012

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The variation of the polysaccharide composition of the brown alga Padina pavonica from the Mediterranean Sea was studied as a function of the collection season (April-July). It was shown that the principal polysaccharide (8.0-13.3% of dry alga weight) was alginic acid. Its content did not undergo significant changes from April to July. The content of water-soluble polysaccharides (laminarans and fucoidans) was low (<0.3% of dry alga weight). Water-soluble polysaccharides of the studied alga were practically pure fucoidan. The amount of laminarans was insignificant (<0.01% of dry alga weight). The content of fucoidans increased in alga samples from May through July. It was shown that P. pavonica is a promising source of alginic acids, which have a high capacity for gelation, and fucoidans, which exhibit antitumor action against RPMI-7951 human melanoma cells.Brown algae were a valuable source of polysaccharides such as alginic acids [1], fucoidans [2], and laminarans [3]. These compounds exhibit a broad spectrum of biological activity and low in vivo toxicity. Unfortunately, their use is hampered by problems with obtaining products with standard properties because the content and structural characteristics of the polysaccharides vary depending on the habitat and collection season [4]. Furthermore, the relationship between structural features and the biological activity of the polysaccharides, especially fucoidans, is poorly studied.The search for accessible sources of biologically active polysaccharides and the study of seasonal variations of their polysaccharide composition in order to determine the optimal collection time and to obtain preparations with standard properties are currently critical [5,6]. This information is required for industrial harvesting of alga.Brown algae of the genus Padina (Dictyotaceae) are widely distributed in the seas of Russia, Lebanon, India, Thailand, and other countries [7-9]. The properties of algal polysaccharides of this family (Lobophora variedata, Dictyota menstrualis, Spatoglossum schroederi, Stoechospermum marginatum, Padina gymnospora, and P. tetrastromatica) were studied. They were interesting as compounds with a broad spectrum of biological activity, e.g., antioxidant, anticoagulant, antithrombic, and antiviral properties [9][10][11][12]. It was also reported that polysaccharides from the brown alga P. pavonia (pavonica) exhibit anticoagulant activity [13].The goal of our work was to study the composition and structural characteristics of polysaccharides from P. pavonica from the Mediterranean Sea as a function of collection time and to determine the antitumor activity of the isolated fucoidans.Alginic acids, laminarans, and fucoidans were isolated using a modification of the published method [14] from P. pavonica collected on the shores of the Mediterranean Sea (Lebanon, Batroun Bay) in April-July 2009 (N 34 15.069c; E 035 39.385c). The modification consisted of selecting the sequence of separation steps (hydrophobic and anion-exchange chromatography) depending on the mo...

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Seasonal variations of the composition and structural characteristics of polysaccharides from the brown alga Costaria costata

Cited by 61 publications

References 23 publications

Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry

Structural analysis of a highly sulfated fucan from the brown alga Laminaria cichorioides by tandem MALDI and ESI mass spectrometry

Fucoidans as Potential Inhibitors of HIV-1

Seasonal variations of the composition, structural features, and antitumor properties of polysaccharides from Padina pavonica (Lebanon) as a function of composition

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