Seasonality and Pediatric Inflammatory Bowel Disease

Lee, Grace J.; Dotson, Jennifer L.; Kappelman, Michael D.; King, Eileen; Pratt, Jesse; Colletti, Richard B.; Bistrick, Sarah; Burkam, Jennifer; Crandall, Wallace

doi:10.1097/mpg.0000000000000362

Cited by 10 publications

(6 citation statements)

References 18 publications

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“…Conversely, another recent work [31] did not confirm the role of the "hygiene hypothesis" in IBD. We also did not find any association between childhood onset IBD and season of birth, in contrast with previous studies [32,33].…”

Section: Previous Literaturecontrasting

confidence: 99%

Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort

Canova

Ludvigsson

Domenicantonio

et al. 2020

IJERPH

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The role of early-life environmental exposures on Inflammatory Bowel Disease (IBD) onset remains unclear. We aimed to quantify the impact of perinatal conditions and antibiotic use in the first 6 and 12 months of life, on the risk of childhood-onset IBD, in a birth cohort of the region Friuli-Venezia Giulia (Italy). A nested case-control design on a longitudinal cohort of 213,515 newborns was adopted. Conditional binomial regression models were used to estimate Odds Ratios (OR) with 95% confidence intervals (CI) for all analyzed risk factors. We identified 164 individuals with IBD onset before the age of 18 years and 1640 controls. None of the considered perinatal conditions were associated with IBD. Analyses on antibiotic exposure were based on 70 cases and 700 controls. Risks were significantly higher for children with ≥4 antibiotic prescriptions in the first 6 and 12 months of life (OR = 6.34; 95%CI 1.68–24.02 and OR = 2.91; 95%CI 1.31–6.45, respectively). This association was present only among patients with Crohn’s disease and those with earlier IBD onset. We found that perinatal characteristics were not associated to IBD, while the frequent use of antibiotics during the first year of life was associated to an increased risk of developing subsequent childhood-onset IBD.

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Section: Previous Literaturecontrasting

confidence: 99%

Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort

Canova

Ludvigsson

Domenicantonio

et al. 2020

IJERPH

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“…Irving and Gibson reported similar findings. 35 Furthermore, other probable factors such as NSAIDs consumption, 36 disease onset at a young age, 22 seasonality patterns, 37 depression, 38 and Quality Of Life (QOL) 23 are linked to IBD exacerbation. It has been noted that the use of NSAIDs has been associated with the onset of IBD or with a clinical flare-up of IBD in a number of case reports 6 ; in contrast, no relationship was reported between NSAIDs treatment and exacerbation of underlying IBD by Bonner et al 7 and Dominitz et al 8 According to a recent retrospective study among patients with IBD, intake of either celecoxib or rofecoxib is linked to clinical relapse of the intestinal disease in 39% of cases, as well as resolution of symptoms after COX-2 inhibitor withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Exacerbation causes among inflammatory bowel disease patients in Guilan Province north of Iran

Hosseini

Mansour-Ghanaei

Shafaghi

et al. 2019

Journal of Coloproctology

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Objective Numerous factors may contribute as triggers to the exacerbation of the condition of patients with inflammatory bowel disease. Methods The medical files of 109 patients with the positive history of inflammatory bowel disease exacerbation between March 2016 and March 2017 were assessed retrospectively. Data were obtained using the inflammatory bowel disease data bank software. The parameters were obtained from the inflammatory bowel disease data bank software. The mentioned parameters were assessed in terms of type and severity of disease using chi-square test in SPSS software. Moreover, binary logistic regression test was used to assess the associations between season of disease onset and inflammatory bowel disease exacerbation as odds ratios with 95% confidence intervals (95% CI). Results Overall, (88.1%) of cases with inflammatory bowel disease exacerbation, had ulcerative colitis. The mean age of patients was 38.14 ± 14.66 years. The disease duration in all patients (ulcerative colitis and Crohn's disease) was 35.43 and 38.85 months, respectively. About 50% of patients with infection were strongyloides stercoralis positive. The occurrence of mild inflammatory bowel disease exacerbation was significantly higher in spring in comparison to other seasons (OR = 3.58; 95% CI 0.1–1.04). Most patients with ulcerative colitis were prescribed salicylates alone (53.12%). Most patients with Crohn's disease with mild and severe activity were non-smokers ( p = 0.058). This difference was marginally significant. Conclusion It is suggested that in future studies, the evidences of distribution of SS infections among patients with inflammatory bowel disease and the history of exacerbation along with other environmental factors such as enhancing nutritional quality and surface water be taken into consideration.

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“…Another study conducted by Bai et al [19] , however, did observe an increase in flares during spring and summer among 409 UC patients. In contrast to this finding, Lee et al [20] reported on an increase in remission during summer among 587 pediatric UC patients. The same trend was observed among 1,325 pediatric CD patients; however, without significance.…”

Section: Discussionmentioning

confidence: 55%

The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study

et al. 2017

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Goals: We aimed to assess the impact of very cold days on inflammatory bowel disease (IBD) flares and infectious gastroenteritis (IG). We defined a cold day using the World Meteorological definition of an ice day, which is a day with a maximum temperature below 0°C. Background: Recently, we have shown that heat waves increase the risk for IG and IBD flares. Study: We retrospectively collected data from 738 IBD and 786 IG patients admitted to the University Hospital of Zurich between 2001 and 2005 and from 506 patients with other noninfectious chronic intestinal inflammations as controls. Climate data were received by the Swiss Federal Office for Meteorology and Climatology. Results: There was no evidence for an increased risk of IBD flares (relative risk, RR = 0.99, 95% confidence interval, CI: 0.72-1.33, p = 0.94) or IG flares (RR = 1.16, 95% CI: 087-1.52, p = 0.30) on very cold days. This negative finding was confirmed in alternative formulations with lagged or cumulative (possibly lagged) effects. Conclusion: In this retrospective controlled observational study, no evidence for an increase in hospital admissions due to flares of IBD and IG during cold days was observed. This may be attributed to not relevantly altered bacterial growth conditions during cold days compared to heat waves.

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Seasonality and Pediatric Inflammatory Bowel Disease

Cited by 10 publications

References 18 publications

Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort

Perinatal and Antibiotic Exposures and the Risk of Developing Childhood-Onset Inflammatory Bowel Disease: A Nested Case-Control Study Based on a Population-Based Birth Cohort

Exacerbation causes among inflammatory bowel disease patients in Guilan Province north of Iran

The Impact of Cold Spells on the Incidence of Infectious Gastroenteritis and Relapse Rates of Inflammatory Bowel Disease: A Retrospective Controlled Observational Study

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