Sebaceous carcinoma of the breast

Abstract

Sebaceous carcinoma (SC) of the breast is a rare malignant tumor and only nine cases, including the present one, have been reported in the English-language literature. The present report describes a case of mammary SC in a 50-year-old Japanese woman. The tumor was gray-white on cut surface and separate from the skin and the nipple. Microscopically, lobules encircled by a fibrous envelope and cords or small cell nests in the stroma were noted. These two types of structures were composed of dark cells and clear foamy cells. The dark cells had large nuclei and amphophilic cytoplasm. The clear foamy cells had numerous lipid vacuoles, confirmed on immunostaining with anti-adipophilin antibody and electron microscopy. In the lobules the gradual transitions from basal dark cells to central clear foamy cells and comedo-like necrosis were observed. The tumor cells were positive on immunohistochemistry for cytokeratins (CAM5.2, AE1/AE3), Her2/neu and androgen receptor but negative for estrogen and progesterone receptors. This is the first case of an androgen receptor-positive mammary SC to be reported, and therefore contributes to the understanding of the clinicopathological features of SC of the breast.

Bilateral sebaceous carcinoma of breast: A case report and review of literature

“…Only nine cases have been reported till date [1]. To our knowledge this is the first case of bilateral sebaceous carcinoma of breast to be reported in the literature.…”

“…Sebaceous carcinoma of breast is a rare malignant tumor of the breast.Only nine cases have been reported till date [1]. Here we present a case of bilateral sebaceous carcinoma breast in an elderly female.…”

Mammary Tumors With Sebaceous Differentiation in Dogs

“…3 Other authors have described tumors with a predominance of sebaceous cells (> 50%), with or without basal cells, and have thus classified them as primary sebaceous carcinomas of the breast. 2,6 Dr Chang and colleagues were prudent in classifying their canine case as a mammary carcinoma with sebaceous differentiation because, apparently, some cells of the typical ductal carcinoma component had undergone sebaceous differentiation. However, because extensive solid multilobulated neoplastic tissue composed of basal and sebaceous cells was also observed, they probably could have used the term mammary sebaceous carcinoma due to the predominance of sebocytic cells in the neoplasm.…”

Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component

“…7 In human medicine, a recent World Health Organization (WHO) classification for breast tumors has recognized mammary sebaceous carcinoma as a distinct subtype of invasive breast carcinomas, 17 although few cases are described in the literature. 8,12 However, in veterinary medicine, no such subtype has been recognized by WHO, 11 probably due to its rarity, with only 1 case having been reported in current literature. 2 The present case report describes a female dog with sebaceous metaplasia in a mammary carcinoma.…”

“…17 Sebaceous metaplasia in mammary tumors is a condition described as rare in human medicine with only a few documented cases. 8,12 In veterinary medicine, the only previously documented case of such a peculiar mammary carcinoma with sebaceous differentiation is described in a 10-year-old mixed-breed female dog. 2 Thus, information on its clinicopathology, treatment, and prognosis remains very limited in both human and veterinary medicine, which makes the current case report an important contribution in terms of comparative pathology.…”