Sebaceous Carcinoma of the Penis

Ornellas, Antônio Augusto; Frota, Rodrigo; Silva, Luis Felipe Lopes da; Dauster, Breno; Quirino, Raul; Schwindt, Aline Barros de Santos; Pereira, Maria Rita

doi:10.1159/000218541

Cited by 16 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there have been five prior reports of primary penile sebaceous carcinoma [30, 31]. Sebaceous carcinoma is a rare malignancy that arises from the sebaceous glands of the skin.…”

Section: Discussionmentioning

confidence: 99%

Non-squamous cell carcinoma of the penis: single-center, 15-year experience

et al. 2013

View full text Add to dashboard Cite

Purpose Penile cancer is a rare malignancy with less than 5 % being non-squamous cell carcinoma (SCC) primary malignancies. We report our 15-year experience of treating non-SCC penile cancer at a tertiary care cancer center. Methods We identified 12 patients with non-SCC of the penis from 1996 to 2012. Demographic and clinical data were abstracted, including histological type, surgical treatment, adjuvant therapy, and clinical course. Results Five patients had sarcoma (three leiomyosarcoma, one spindle cell carcinoma, and one epithelioid sarcoma), four had melanoma, two had extramammary Paget’s disease (EPD), and one had sebaceous carcinoma. Median follow-up was 37.5 months (mean 45.8 months). Tumor staging for melanoma was pT1aN3, pTisNx, pTxNxM1b, and pT3bN0. Patients with melanoma were treated with penile sparing surgery; two are alive without disease, one is alive with disease, and one patient with metastasis at presentation died of disease at 16.3 months. The patients with sarcoma and deep-seated or node-positive disease died of disease at a mean of 49.7 months. Two patients with EPD were treated with wide local excision of the lesions and were both pT1Nx. The remaining patient had sebaceous carcinoma treated with excisional biopsy and was free of disease at 32.0 months. Conclusions Non-SCC of the penis is primarily treated surgically, with the goal of complete excision at the time of treatment. The utilization of lymphadenectomy is less clear in these malignancies, but aggressive approaches should be considered in appropriate patients. Tumor stage and nodal status are important in determining patient outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Non-squamous cell carcinoma of the penis: single-center, 15-year experience

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Traditionally, they are divided into ocular and extraocular variants, though both categories have overlapping histological features. Lesions present as masses on the eyelids, the head and neck, trunk or even genitals . Ulceration may occur and clinical diagnosis is rare, as tumors resemble other non‐melanoma skin cancers or, in the case of ocular lesions, benign conditions including chalazions.…”

Section: Sebaceous Neoplasmsmentioning

confidence: 99%

“…Germ line mutations in the DNA mismatch repair (MMR) genes MSH2 , MSH6 , MLH1 and PMS2 result in microsatellite instability (MSI) and a hypermutable phenotype . Cutaneous neoplasms include sebaceous adenoma, sebaceous epithelioma, keratoacanthomas (often with sebaceous differentiation) and, occasionally, sebaceous carcinomas . Though the most common visceral malignancy is colorectal adenocarcinoma, genitourinary tract, breast and hepatobiliary tumors are also associated with the syndrome and may occur in the absence of colorectal carcinoma .…”

Section: Sebaceous Neoplasmsmentioning

confidence: 99%

See 1 more Smart Citation

Folliculosebaceous neoplasms: A review of clinical and histological features

Bhawan

2017

The Journal of Dermatology

View full text Add to dashboard Cite

Numerous benign and occasionally malignant tumors arise from the folliculosebaceous apparatus. Confusing terminology, rarity of malignant variants and overlapping histological features can lead to diagnostic uncertainty. This review highlights the clinical and histopathological features that help to classify these entities, as well as the various syndromes associated with certain members of this large family of tumors.

show abstract

“…Immunohistochemical stains adipophilin and perilipin for the identification of lipid within specimens have proven to be useful. 57–61 Experience with the use of SLN biopsy in sebaceous carcinoma with ocular 29,33,62 and extraocular 63–65 involvement is limited. To date, SLN positivity rates range from 17% (2/12) 62 to 20% (1/5).…”

Section: Sebaceous Carcinoma Of the Eyelid And Conjunctivamentioning

confidence: 99%