Sebaceous epithelioma: A review of twenty-one cases

Dinneen, Annette M.; Mehregan, Darius

doi:10.1016/s0190-9622(96)90833-6

Cited by 45 publications

(13 citation statements)

References 10 publications

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“…Sebaceous carcinomas exhibited malignant features such as infiltrative architecture and/or cytologic atypia to a degree unacceptable in a benign lesion 27. Cystic change and keratoacanthoma-like architecture were assessed according to prior descriptions of these features 28–30. Patient demographics and tumor location were obtained from pathology reports.…”

Section: Methodsmentioning

confidence: 99%

p53 Staining Correlates With Tumor Type and Location in Sebaceous Neoplasms

Shalin

Sakharpe

Lyle

et al. 2012

The American Journal of Dermatopathology

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Sebaceous neoplasms are commonly considered in their relationship to the Muir-Torre Syndrome and the now well-documented loss of DNA mismatch repair proteins leading to microsatellite instability. However, sebaceous neoplasms showing microsatellite instability comprise only a subset of this group of tumors, and thus alternative tumorigenic mechanisms must exist. This paper explores the relationship of p53, a tumor suppressor implicated in other cutaneous malignancies, and sebaceous neoplasia. We examined 94 sebaceous tumors from 92 patients. Tumors with strong nuclear p53 staining were significantly associated with the diagnosis of sebaceous carcinoma compared to benign sebaceous lesions, most notably for periocular carcinomas. Importantly, nuclear mismatch repair protein expression was intact in all lesions showing p53 alterations, suggesting that p53 dysfunction may represent a divergent pathway in the molecular pathogenesis of these tumors.

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Section: Methodsmentioning

confidence: 99%

p53 Staining Correlates With Tumor Type and Location in Sebaceous Neoplasms

Shalin

Sakharpe

Lyle

et al. 2012

The American Journal of Dermatopathology

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“…proposed the term sebaceoma for benign sebaceous neoplasms and they provided a clear classification of neoplasms with sebaceous differentiation . Despite their proposal, some confusion has remained concerning sebaceoma and its related neoplasms with sebaceous differentiation . Even in recent articles, sebaceous neoplasms are classified into sebaceous adenomas (SA), sebaceous epitheliomas (SE)/sebaceomas and SC.…”

Section: Sebaceous Neoplasmsmentioning

confidence: 99%

“…111,112 Despite their proposal, some confusion has remained concerning sebaceoma and its related neoplasms with sebaceous differentiation. 113,114 Even in recent articles, [115][116][117][118] sebaceous neoplasms are classified into sebaceous adenomas (SA), sebaceous epitheliomas (SE)/sebaceomas and SC. The histological criteria of them were as follows.…”

Section: Classification Of Sebaceous Neoplasms: Low-grade Sebaceous Cmentioning

confidence: 99%

“…In general, sebaceous neoplasms of intermediate malignancy have been diagnosed as "SE", but the definition of SE has not been clearly documented by most authors. 114 Some authors use this term for lesions identical to sebaceoma that they consider to be benign sebaceous neoplasms with predominant proliferation of immature cells. [115][116][117][118] Kaminska et al 123 reported a similar neoplasm in a renal transplant patient without Muir-Torre syndrome, and designated it as a borderline sebaceous neoplasm (BSN).…”

Section: Classification Of Sebaceous Neoplasms: Low-grade Sebaceous Cmentioning

confidence: 99%

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Topics in histopathology of sweat gland and sebaceous neoplasms

Ansai

2017

The Journal of Dermatology

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This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC + , SMBC ). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and ZEB2/ SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC is rare, especially extraocular SC, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive SC. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well-defined architecture and no atypia), borderline sebaceous neoplasm (low-grade SC; an intermediate tumor with well-defined architecture and nuclear atypia) and SC (a malignant tumor with invasive growth and evident nuclear atypia).

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“…[1][2][3][4][5][6][7] Whereas immunohistochemical techniques for expression of adipophilin, epithelial membrane antigen (EMA), BerEP4 and several other markers are well established in the differential diagnosis of sebaceous gland tumors, [8][9][10][11][12][13][14][15][16][17][18] our information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. [1][2][3][4][5][6][7] Whereas immunohistochemical techniques for expression of adipophilin, epithelial membrane antigen (EMA), BerEP4 and several other markers are well established in the differential diagnosis of sebaceous gland tumors, [8][9][10][11][12][13][14][15][16][17][18] our information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce.…”

Section: Introductionmentioning

confidence: 99%

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors

Boecker

Reusch

Mielke

et al. 2019

The Journal of Dermatology

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The histogenesis of extraocular sebaceous carcinomas is – in contrast to ocular sebaceous carcinomas – unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki‐67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63+ K5+ progenitors which generate the K10+ luminal cells of sebaceous ducts; and (ii) p63+ K5+ K7+ progenitors which finally generate K7+ adipophilin+ EMA+ sebocytes. Without exception, all types of sebaceous tumors contained p63+ K5+ cells. Furthermore, these tumors showed a cellular hierarchy and differentiation to adipophilin+ and/or EMA+ mature sebocytes and to K10+ ductal cells through intermediary cells. Notably, a considerable number of sebaceous tumors lack the K7 pathway of cell maintenance in the normal sebaceous lobule. Based on our data, we propose a cellular algorithmic model of the hierarchy of normal sebaceous glands and of sebocytic tumors in which p63+ K5+ cells play a major role.

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Sebaceous epithelioma: A review of twenty-one cases

Cited by 45 publications

References 10 publications

p53 Staining Correlates With Tumor Type and Location in Sebaceous Neoplasms

p53 Staining Correlates With Tumor Type and Location in Sebaceous Neoplasms

Topics in histopathology of sweat gland and sebaceous neoplasms

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors

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