Seborrheic Dermatitis in Older Adults: Pathogenesis and Treatment Options

Sowell, Josiah; Peña, S.M.; Elewski, Boni E.

doi:10.1007/s40266-022-00930-5

Cited by 15 publications

(7 citation statements)

References 50 publications

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“…The underlying mechanism of sebum production induced by RC remains unclear, but it is believed to be associated with the increase in ceramides production following RC consumption. Ceramides are known to enhance lipid synthesis in sebocyte culture models [35]. Interestingly, sebum production in all three examined areas improved drastically to the normal healthy range, from 70 to 180 for cheek, 55 to 130 for neck, and >6 for arm [36,37].…”

Section: Discussionmentioning

confidence: 96%

Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

Leo¹,

Tan

Amini

et al. 2022

Nutrients

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Ceramides plays a crucial role in maintaining skin barrier function. Although foregoing evidence supported beneficial effects of topical ceramides for restoration of the skin barrier, studies on oral ceramides are extremely scarce, with most published data collected from in vivo and in vitro models. Thus, this study aimed to evaluate the efficacy of rice ceramides (RC) supplementation to improve skin barrier function and as a depigmenting agent through comprehensive clinical assessments. This study investigated the beneficial effects of orally administered RC supplementation in 50 voluntary participants. Skin hydration, firmness and elasticity, transepidermal water loss (TEWL), melanin index (MI), erythema index (EI), sebum production, pH, and wrinkle severity were assessed at baseline and during monthly follow-up visits. RC supplementation was found to significantly (p < 0.01) improve skin hydration, sebum production, firmness and elasticity, and wrinkle severity for three assessed areas, namely the left cheek, dorsal neck, and right inner forearm. Additionally, RC significantly (p < 0.01) reduced the rates of TEWL, levels of MI and EI. Analyses of data indicated that participants at older age were more responsive towards the effect of RC supplementation. Our findings suggest that RC supplementation can effectively improve skin barrier function, reduce wrinkle severity, and reduce pigmentation.

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Section: Discussionmentioning

confidence: 96%

Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

Leo¹,

Tan

Amini

et al. 2022

Nutrients

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“…The density of Malassezia spp has always been connected with the severity of the disease [ 7 ]. Topical antifungals are the primary treatment for this disease by reduction of the yeast [ 8 ]. Silver-white scales, well-circumscribed erythema, and hair casts characterize scalp psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Seborrheic dermatitis-like adult tinea capitis due to Trichophyton rubrum in an elderly man

Xie

Chen

Liu

et al. 2023

Medical Mycology Case Reports

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“…Akbaş et al found that the BMI of the patients was significantly higher compared to the controls [3]. Sanders et al found that the majority of SD patients had BMI ranging from 25-30 [19]. Linder et al found that SD patients were more likely to be obese [15].…”

Section: Leptinmentioning

confidence: 99%

Assessment of Leptin Level in Serum of Patients with Seborrheic Dermatitis

A.Soliman,

M.Al Refaei,

M. Abdel Khalik

et al. 2024

Benha Journal of Applied Sciences

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Background: Seborrheic dermatitis (SD) is a prevalent dermatological condition encountered in medical settings, known by various names such as sebo psoriasis, seborrheic eczema, and dandruff, among others. the rising prevalence of metabolic syndrome (MetS) poses a global health challenge, with emerging interest in its connection to various dermatological conditions, including SD, conditions like obesity are associated with increased leptin levels and resistance to its action, suggesting a complex interaction between leptin and skin health. Objective: This review aims to assess serum level of leptin in patients with SD and its relation to MetS in these patients, if any. Conclusions: patients with seborrheic dermatitis exhibit significantly higher serum leptin levels compared to healthy controls, indicating a potential role of leptin in the pathogenesis of the disease. Notably, serum leptin levels correlated with the severity of the disease and showed potential as a biomarker for disease severity.

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Seborrheic Dermatitis in Older Adults: Pathogenesis and Treatment Options

Cited by 15 publications

References 50 publications

Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

Effect of Rice (Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

Seborrheic dermatitis-like adult tinea capitis due to Trichophyton rubrum in an elderly man

Assessment of Leptin Level in Serum of Patients with Seborrheic Dermatitis

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