Seborrhoeic keratosis removal in a multicentre phase I/II clinical trial using a novel topical formulation (BL-5010)

Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)

“…2,4 An extensive medical literature review revealed no prior large randomized controlled trials evaluating drug or procedural treatment options for removal of SKs. [5][6][7][8] After up to 2 treatments with 40% hydrogen peroxide topical solution, significant improvements were seen in the US Food and Drug Administrationemandated end point of clearing all 4 of 4 SKs from the face, trunk, and extremities compared with vehicle. Adverse effects were limited to local skin reactions, which were mostly mild to moderate and self-limited.…”

Seborrheic keratosis

“…Two applications three weeks apart led to healing of at least three of four treated SK in about 30% of the patients 68–70 . As further possible alternatives, a combined preparation of alpha‐ and beta‐hydroxy acids, urea and thuja showed a success rate of 99% in a study with 20 subjects, 71 and topical use of 5% calcium dobesilate cream 72 and a combination of trichloroacetic acid and formic acid 73 also proved effective, although studies on larger groups of patients are lacking to date. Thus, these methods cannot yet be regarded as established treatments of SK.…”

Seborrhoische Keratosen

“…Eine zweimalige Anwendung im Abstand von drei Wochen führte hier bei circa 30% der Patienten zu einer Abheilung von mindestens drei von vier behandelten SK 68–70 . Als zusätzliche mögliche Alternativen zeigte ein Kombinationspräparat aus Alpha‐ und Beta‐Hydroxysäuren, Harnstoff und Thuja bei einer Studie an 20 Probanden eine Erfolgsquote von 99%, 71 und auch die topische Anwendung einer 5%igen Kalziumdobesilat‐Creme 72 sowie einer Kombination aus Trichloressigsäure und Ameisensäure 73 erwiesen sich als gut wirksam, wobei Studien an größeren Patientenkollektiven bislang fehlen und diese Behandlungsmethoden daher noch nicht als etablierte Therapien der SK gelten können. In einer In‐vitro ‐Studie von Neel et al.…”