Sebum Excretion in Acromegaly

Burton, J.L.; Libman, L. J.; Cunliffe, W.J.; Wilkinson, Robert H.; Hall, R. J. C.; Shuster, Sam

doi:10.1136/bmj.1.5797.406

Cited by 50 publications

(27 citation statements)

References 11 publications

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“…On the other hand, the increased serum GH levels in acromegaly has been associated with enhanced sebum secretion (Burton et al, 1972) an observation that could be confirmed by GH…”

Section: Growth Factorsmentioning

confidence: 81%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo an in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone /insulin like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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“…On the other hand, the increased serum GH levels in acromegaly has been associated with enhanced sebum secretion (Burton et al, 1972) an observation that could be confirmed by GH…”

Section: Growth Factorsmentioning

confidence: 81%

Skin and brain age together: The role of hormones in the ageing process

Makrantonaki

Schönknecht

Hossini

et al. 2010

Experimental Gerontology

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“…Growth hormone (GH) activity is considered to be mainly attributed to IGF but GH has also been shown to exhibit direct effects on human skin cells. 44 The increased serum GH levels in acromegaly are associated with enhanced sebum secretion, 45 an observation that could be confirmed by GH treatment of human SZ95 sebocytes in vitro. 46 In acne vulgaris, increased sebum production peaks in mid-adolescence at a time that GH and IGF-I reach their highest serum levels.…”

Section: 21mentioning

confidence: 87%

An update on the role of the sebaceous gland in the pathogenesis of acne

Makrantonaki

Gancevičienė²,

Zouboulis³

2011

Dermato-Endocrinology

236

168

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“…The increased serum GH levels in acromegaly are associated with enhanced sebum secretion [48], an observation that could be confirmed by GH treatment of human sebocytes in vitro [49]. In acne vulgaris, increased sebum production peaks in mid-adolescence at a time that GH and IGF-I reach their highest serum levels [50].…”

Section: Ghmentioning

confidence: 86%

New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today’s Pre-Clinical Data into Tomorrow’s Daily Clinical Practice

Zampeli¹,

Makrantonaki²,

Tzellos³

et al. 2012

CPB

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The human sebaceous gland is a microscopic branched type multiacinar gland been present everywhere on the body except on the palms and soles, whereas they are sparsely located on the dorsum of hands and feet. Several medical conditions are related with sebaceous gland pathology, such as acne, sebaceous hyperplasia, sebaceous adenoma and sebaceous carcinoma. Acne is a common, complex, chronic disorder of the human pilosebaceous unit that mostly occurs in adolescence and young adulthood. The sebaceous gland plays an exquisite role in the initiation of the disease. The multifactorial nature of the pathogenesis of acne includes increased sebum production, alteration of the quality of sebum lipids, inflammatory processes, interaction with neuropeptides and dysregulation of the hormone microenvironment, follicular hyperkeratinization and inflammation maintained by Propionbacterium acnes products within the follicle. On the other hand, the sebaceous gland, as a major and critical compartment of human skin, is also affected through ageing, both intrinsic and extrinsic, which lead to distinct clinical and histological changes. Intrinsic ageing of the sebaceous gland is determined primarily by genetic factors and hormonal status, with androgens playing a major role. A clinical manifestation associated with intrinsic ageing changes is skin xerosis. Extrinsic ageing of human sebaceous gland is mainly caused by accumulating UV irradiation, especially UVA. Photoageing of sebaceous gland is expressed with a wide spectrum of benign and malignant sebaceous tumours, such as sebaceous hyperplasia, sebaceous carcinoma and Muir-Torre syndrome. This review will focus on the pathogenesis of the most common sebaceous gland diseases and their molecular pathways which may represent future pharmaceutical targets.

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Sebum Excretion in Acromegaly

Cited by 50 publications

References 11 publications

Skin and brain age together: The role of hormones in the ageing process

Skin and brain age together: The role of hormones in the ageing process

An update on the role of the sebaceous gland in the pathogenesis of acne

New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today’s Pre-Clinical Data into Tomorrow’s Daily Clinical Practice

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